登録情報 | データベース: PDB / ID: 8toh |
---|
タイトル | Cryo-EM structure of monomeric alpha-Klotho |
---|
要素 | Klotho |
---|
キーワード | SIGNALING PROTEIN |
---|
機能・相同性 | 機能・相同性情報
norepinephrine biosynthetic process / beta-glucuronidase / FGFR1c and Klotho ligand binding and activation / beta-glucuronidase activity / positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway / fibroblast growth factor receptor binding / vitamin D binding / energy reserve metabolic process / Downstream signaling of activated FGFR1 / Phospholipase C-mediated cascade: FGFR1 ...norepinephrine biosynthetic process / beta-glucuronidase / FGFR1c and Klotho ligand binding and activation / beta-glucuronidase activity / positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway / fibroblast growth factor receptor binding / vitamin D binding / energy reserve metabolic process / Downstream signaling of activated FGFR1 / Phospholipase C-mediated cascade: FGFR1 / response to vitamin D / negative regulation of systemic arterial blood pressure / response to angiotensin / beta-glucosidase activity / fibroblast growth factor binding / PI-3K cascade:FGFR1 / PI3K Cascade / fibroblast growth factor receptor signaling pathway / positive regulation of bone mineralization / calcium ion homeostasis / SHC-mediated cascade:FGFR1 / FRS-mediated FGFR1 signaling / response to activity / determination of adult lifespan / Negative regulation of FGFR1 signaling / hormone activity / Constitutive Signaling by Aberrant PI3K in Cancer / PIP3 activates AKT signaling / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / carbohydrate metabolic process / apical plasma membrane / extracellular space / extracellular exosome / extracellular region / membrane / plasma membrane類似検索 - 分子機能 Glycosyl hydrolases family 1, N-terminal conserved site / Glycosyl hydrolases family 1 N-terminal signature. / Glycosyl hydrolase family 1 / Glycoside hydrolase family 1 / Glycoside hydrolase superfamily類似検索 - ドメイン・相同性 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | 電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.29 Å |
---|
データ登録者 | Schnicker, N.J. / Xu, Z. / Mohammad, A. / Gakhar, L. / Huang, C.L. |
---|
資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
---|
National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) | RO1 DK100605 | 米国 |
|
---|
引用 | ジャーナル: To Be Published タイトル: Exploring the a-Klotho conformational landscape 著者: Schnicker, N.J. / Xu, Z. / Mohammad, A. / Gakhar, L. / Huang, C.L. |
---|
履歴 | 登録 | 2023年8月3日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2024年8月14日 | Provider: repository / タイプ: Initial release |
---|
|
---|