- PDB-8tbq: The crystal structure of human VISTA extra cellular domain in com... -
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Basic information
Entry
Database: PDB / ID: 8tbq
Title
The crystal structure of human VISTA extra cellular domain in complex with Fab fragment of pH-selective anti-VISTA antibody
Components
SNS-101 Fab heavy chain
SNS-101 Fab light chain
V-type immunoglobulin domain-containing suppressor of T-cell activation
Keywords
PROTEIN BINDING / IMMUNE SYSTEM / VISTA / pH-selective / SNS-101 / PD-1
Function / homology
Function and homology information
positive regulation of collagen catabolic process / negative regulation of CD8-positive, alpha-beta T cell proliferation / positive regulation of endopeptidase activity / negative regulation of alpha-beta T cell activation / negative regulation of CD4-positive, alpha-beta T cell proliferation / positive regulation of regulatory T cell differentiation / negative regulation of interleukin-17 production / zymogen activation / negative regulation of interleukin-10 production / negative regulation of type II interferon production ...positive regulation of collagen catabolic process / negative regulation of CD8-positive, alpha-beta T cell proliferation / positive regulation of endopeptidase activity / negative regulation of alpha-beta T cell activation / negative regulation of CD4-positive, alpha-beta T cell proliferation / positive regulation of regulatory T cell differentiation / negative regulation of interleukin-17 production / zymogen activation / negative regulation of interleukin-10 production / negative regulation of type II interferon production / negative regulation of tumor necrosis factor production / endopeptidase activator activity / regulation of immune response / positive regulation of cell migration / positive regulation of gene expression / enzyme binding / identical protein binding / plasma membrane Similarity search - Function
#256 - Apr 2021 SARS-CoV-2 Spike and Antibodies similarity (1)
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Assembly
Deposited unit
H: SNS-101 Fab heavy chain L: SNS-101 Fab light chain P: V-type immunoglobulin domain-containing suppressor of T-cell activation A: SNS-101 Fab heavy chain B: SNS-101 Fab light chain Q: V-type immunoglobulin domain-containing suppressor of T-cell activation hetero molecules
Mass: 24336.129 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Cell line: CHO / Cell line (production host): CHO / Production host: Cricetulus griseus (Chinese hamster)
#2: Antibody
SNS-101Fablightchain
Mass: 23414.855 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Cell line (production host): CHO / Production host: Cricetulus griseus (Chinese hamster)
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