登録情報 | データベース: PDB / ID: 8t9u |
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タイトル | Human PU.1 ETS-domain (165-270) in complex with d(AATAAGCGIAAGTGGG) |
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要素 | - DNA (5'-D(*AP*AP*TP*AP*AP*GP*CP*GP*IP*AP*AP*GP*TP*GP*GP*G)-3')
- DNA (5'-D(*TP*CP*CP*CP*AP*CP*TP*TP*CP*CP*GP*CP*TP*TP*AP*T)-3')
- Transcription factor PU.1
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キーワード | TRANSCRIPTION / transcription factor / protein-DNA complex / ETS family / ETS / PU.1 / TRANSCRIPTION-DNA complex |
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機能・相同性 | 機能・相同性情報
positive regulation of antifungal innate immune response / regulation of myeloid progenitor cell differentiation / pro-T cell differentiation / negative regulation of neutrophil degranulation / myeloid leukocyte differentiation / positive regulation of microglial cell mediated cytotoxicity / TRAIL-activated apoptotic signaling pathway / STAT family protein binding / endothelial to hematopoietic transition / negative regulation of adipose tissue development ...positive regulation of antifungal innate immune response / regulation of myeloid progenitor cell differentiation / pro-T cell differentiation / negative regulation of neutrophil degranulation / myeloid leukocyte differentiation / positive regulation of microglial cell mediated cytotoxicity / TRAIL-activated apoptotic signaling pathway / STAT family protein binding / endothelial to hematopoietic transition / negative regulation of adipose tissue development / pericyte cell differentiation / defense response to tumor cell / negative regulation of non-canonical NF-kappaB signal transduction / regulation of DNA-binding transcription factor activity / oncogene-induced cell senescence / negative regulation of protein localization to chromatin / positive regulation of p38MAPK cascade / DNA-binding transcription repressor activity / positive regulation of B cell differentiation / DNA-binding transcription activator activity / negative regulation of NF-kappaB transcription factor activity / interleukin-6-mediated signaling pathway / NFAT protein binding / cis-regulatory region sequence-specific DNA binding / protein sequestering activity / transcription initiation-coupled chromatin remodeling / positive regulation of miRNA transcription / Transcriptional regulation of granulopoiesis / regulation of erythrocyte differentiation / histone deacetylase binding / RUNX1 regulates transcription of genes involved in differentiation of HSCs / DNA-binding transcription factor binding / transcription regulator complex / sequence-specific DNA binding / RNA polymerase II-specific DNA-binding transcription factor binding / transcription cis-regulatory region binding / molecular adaptor activity / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of gene expression / negative regulation of DNA-templated transcription / chromatin binding / regulation of transcription by RNA polymerase II / chromatin / regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / RNA binding / nucleoplasm / nucleus類似検索 - 分子機能 Ets-domain signature 1. / ETS family / Ets-domain signature 2. / Ets domain / Ets-domain / Ets-domain profile. / erythroblast transformation specific domain / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily類似検索 - ドメイン・相同性 DNA / DNA (> 10) / Transcription factor PU.1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) DNA molecule (その他) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.47 Å |
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データ登録者 | Terrell, J.R. / Poon, G.M.K. |
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資金援助 | 米国, 4件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) | HL155178 | 米国 | National Science Foundation (NSF, United States) | MCB2028902 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM137160 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM111749 | 米国 |
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引用 | ジャーナル: Structure / 年: 2024 タイトル: Dissection of integrated readout reveals the structural thermodynamics of DNA selection by transcription factors. 著者: Vernon, T.N. / Terrell, J.R. / Albrecht, A.V. / Germann, M.W. / Wilson, W.D. / Poon, G.M.K. |
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履歴 | 登録 | 2023年6月26日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2023年11月29日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年12月13日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2024年1月17日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.year |
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