Entry | Database: PDB / ID: 8t5i |
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Title | Crystal structure of human WDR5 in complex with MR4397 |
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Components | WD repeat-containing protein 5 |
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Keywords | TRANSCRIPTION / WD-repeat / WDR / WDR5 / SGC |
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Function / homology | Function and homology information
MLL3/4 complex / Set1C/COMPASS complex / MLL1/2 complex / ATAC complex / NSL complex / histone H3K4 methyltransferase activity / Cardiogenesis / histone methyltransferase complex / regulation of tubulin deacetylation / Formation of WDR5-containing histone-modifying complexes ...MLL3/4 complex / Set1C/COMPASS complex / MLL1/2 complex / ATAC complex / NSL complex / histone H3K4 methyltransferase activity / Cardiogenesis / histone methyltransferase complex / regulation of tubulin deacetylation / Formation of WDR5-containing histone-modifying complexes / regulation of cell division / regulation of embryonic development / MLL1 complex / transcription factor TFIID complex / RNA polymerase II general transcription initiation factor activity / histone acetyltransferase complex / positive regulation of gluconeogenesis / transcription initiation-coupled chromatin remodeling / methylated histone binding / skeletal system development / gluconeogenesis / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / mitotic spindle / PKMTs methylate histone lysines / RMTs methylate histone arginines / Activation of anterior HOX genes in hindbrain development during early embryogenesis / Neddylation / HATs acetylate histones / histone binding / regulation of cell cycle / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / nucleoplasm / nucleusSimilarity search - Function G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamilySimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.7 Å |
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Authors | Kimani, S. / Dong, A. / Li, F. / Loppnau, P. / Ackloo, S. / Vedadi, M. / Brown, P.J. / Arrowsmith, C.H. / Edwards, A.M. / Halabelian, L. / Structural Genomics Consortium (SGC) |
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Funding support | 1items Organization | Grant number | Country |
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Other private | | |
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Citation | Journal: To be published Title: Crystal structure of human WDR5 in complex with MR4397 Authors: Kimani, S. / Dong, A. / Li, F. / Loppnau, P. / Ackloo, S. / Vedadi, M. / Brown, P.J. / Arrowsmith, C.H. / Edwards, A.M. / Halabelian, L. / Structural Genomics Consortium (SGC) |
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History | Deposition | Jun 13, 2023 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Aug 9, 2023 | Provider: repository / Type: Initial release |
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Revision 1.1 | May 22, 2024 | Group: Data collection / Category: chem_comp_atom / chem_comp_bond |
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