登録情報 データベース : PDB / ID : 8t5g 構造の表示 ダウンロードとリンクタイトル SOS2 co-crystal structure with fragment bound (compound 12) 要素Son of sevenless homolog 2 詳細 キーワード SIGNALING PROTEIN機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
regulation of pro-B cell differentiation / regulation of T cell differentiation in thymus / Interleukin-15 signaling / Activation of RAC1 / NRAGE signals death through JNK / B cell homeostasis / regulation of T cell proliferation / RAC1 GTPase cycle / guanyl-nucleotide exchange factor activity / insulin receptor signaling pathway ... regulation of pro-B cell differentiation / regulation of T cell differentiation in thymus / Interleukin-15 signaling / Activation of RAC1 / NRAGE signals death through JNK / B cell homeostasis / regulation of T cell proliferation / RAC1 GTPase cycle / guanyl-nucleotide exchange factor activity / insulin receptor signaling pathway / G alpha (12/13) signalling events / Ras protein signal transduction / protein heterodimerization activity / plasma membrane / cytosol 類似検索 - 分子機能 Ras guanine-nucleotide exchange factor, conserved site / Ras Guanine-nucleotide exchange factors domain signature. / RasGEF N-terminal motif / Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif / Ras-like guanine nucleotide exchange factor, N-terminal / Ras-like guanine nucleotide exchange factor / Ras guanine-nucleotide exchange factors N-terminal domain profile. / Ras guanine nucleotide exchange factor domain superfamily / Ras guanine-nucleotide exchange factor, catalytic domain superfamily / RasGEF domain ... Ras guanine-nucleotide exchange factor, conserved site / Ras Guanine-nucleotide exchange factors domain signature. / RasGEF N-terminal motif / Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif / Ras-like guanine nucleotide exchange factor, N-terminal / Ras-like guanine nucleotide exchange factor / Ras guanine-nucleotide exchange factors N-terminal domain profile. / Ras guanine nucleotide exchange factor domain superfamily / Ras guanine-nucleotide exchange factor, catalytic domain superfamily / RasGEF domain / Ras guanine-nucleotide exchange factors catalytic domain profile. / Guanine nucleotide exchange factor for Ras-like small GTPases / Ras guanine-nucleotide exchange factors catalytic domain / : / SOS1/NGEF-like PH domain / Dbl homology (DH) domain superfamily / RhoGEF domain / Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases / Dbl homology (DH) domain / Dbl homology (DH) domain profile. / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / Histone-fold / PH-like domain superfamily 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.92 Å 詳細データ登録者 Gunn, R.J. / Lawson, J.D. / Ivetac, A. / Ulaganathan, T. / Coulombe, R. / Fethiere, J. 資金援助 米国, 1件 詳細 詳細を隠す組織 認可番号 国 Other private 米国
引用ジャーナル : J.Med.Chem. / 年 : 2024タイトル : Discovery of Five SOS2 Fragment Hits with Binding Modes Determined by SOS2 X-Ray Cocrystallography.著者: Smith, C.R. / Chen, D. / Christensen, J.G. / Coulombe, R. / Fethiere, J. / Gunn, R.J. / Hollander, J. / Jones, B. / Ketcham, J.M. / Khare, S. / Kuehler, J. / Lawson, J.D. / Marx, M.A. / ... 著者 : Smith, C.R. / Chen, D. / Christensen, J.G. / Coulombe, R. / Fethiere, J. / Gunn, R.J. / Hollander, J. / Jones, B. / Ketcham, J.M. / Khare, S. / Kuehler, J. / Lawson, J.D. / Marx, M.A. / Olson, P. / Pearson, K.E. / Ren, C. / Tsagris, D. / Ulaganathan, T. / Van't Veer, I. / Wang, X. / Ivetac, A. 履歴 登録 2023年6月13日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2024年1月10日 Provider : repository / タイプ : Initial release改定 1.1 2024年1月24日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.year / _citation_author.identifier_ORCID
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