Entry Database : PDB / ID : 8ss0 Structure visualization Downloads & linksTitle Human sterol 14 alpha-demethylase (CYP51) in complex with the reaction intermediate 14 alpha-aldehyde dihydrolanosterol ComponentsLanosterol 14-alpha demethylase Details Keywords OXIDOREDUCTASE / MONOOXYGENASE / CYTOCHROME P450 / CYP51 / ENDOPLASMIC RETICULUM / STEROL BIOSYNTHESISFunction / homology Function and homology informationFunction Domain/homology Component
sterol 14alpha-demethylase / sterol 14-demethylase activity / negative regulation of amyloid-beta clearance / sterol metabolic process / Cholesterol biosynthesis / EGR2 and SOX10-mediated initiation of Schwann cell myelination / steroid biosynthetic process / cholesterol biosynthetic process / negative regulation of protein secretion / Endogenous sterols ... sterol 14alpha-demethylase / sterol 14-demethylase activity / negative regulation of amyloid-beta clearance / sterol metabolic process / Cholesterol biosynthesis / EGR2 and SOX10-mediated initiation of Schwann cell myelination / steroid biosynthetic process / cholesterol biosynthetic process / negative regulation of protein secretion / Endogenous sterols / Activation of gene expression by SREBF (SREBP) / negative regulation of protein catabolic process / oxidoreductase activity / iron ion binding / endoplasmic reticulum membrane / heme binding / membrane Similarity search - Function : / Cytochrome P450, E-class, group IV / Cytochrome P450, conserved site / Cytochrome P450 cysteine heme-iron ligand signature. / Cytochrome P450 / Cytochrome P450 superfamily / Cytochrome P450 Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.25 Å DetailsAuthors Hargrove, T.Y. / Wawrzak, Z. / Guengerich, F.P. / Lepesheva, G.I. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM067871 United States
CitationJournal : Angew.Chem.Int.Ed.Engl. / Year : 2024Title : Oxygen-18 Labeling Reveals a Mixed Fe-O Mechanism in the Last Step of Cytochrome P450 51 Sterol 14 alpha-Demethylation.Authors : McCarty, K.D. / Tateishi, Y. / Hargrove, T.Y. / Lepesheva, G.I. / Guengerich, F.P. History Deposition May 8, 2023 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jan 17, 2024 Provider : repository / Type : Initial releaseRevision 1.1 Jan 24, 2024 Group : Database references / Category : citationItem : _citation.page_first / _citation.page_last ... _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title Revision 1.2 Mar 6, 2024 Group : Database references / Category : citation / citation_authorItem : _citation.journal_volume / _citation_author.identifier_ORCID
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