Entry Database : PDB / ID : 8sk5 Structure visualization Downloads & linksTitle Crystal structure of the SARS-CoV-2 neutralizing VHH 7A9 bound to the spike receptor binding domain ComponentsSpike protein S1 anti-SARS-CoV-2 receptor binding domain VHH DetailsKeywords ANTIVIRAL PROTEIN / VHH / ComplexFunction / homology Function and homology informationFunction Domain/homology Component
Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / entry receptor-mediated virion attachment to host cell ... Maturation of spike protein / viral translation / Translation of Structural Proteins / Virion Assembly and Release / host cell surface / host extracellular space / suppression by virus of host tetherin activity / Induction of Cell-Cell Fusion / structural constituent of virion / entry receptor-mediated virion attachment to host cell / host cell endoplasmic reticulum-Golgi intermediate compartment membrane / receptor-mediated endocytosis of virus by host cell / membrane fusion / Attachment and Entry / positive regulation of viral entry into host cell / receptor-mediated virion attachment to host cell / receptor ligand activity / host cell surface receptor binding / fusion of virus membrane with host plasma membrane / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / SARS-CoV-2 activates/modulates innate and adaptive immune responses / host cell plasma membrane / virion membrane / identical protein binding / membrane / plasma membrane Similarity search - Function Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2 / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like ... Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2 / Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like / Betacoronavirus spike (S) glycoprotein S1 subunit N-terminal (NTD) domain profile. / Spike glycoprotein, N-terminal domain superfamily / Betacoronavirus spike (S) glycoprotein S1 subunit C-terminal (CTD) domain profile. / Spike glycoprotein, betacoronavirus / Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus / Spike S1 subunit, receptor binding domain superfamily, betacoronavirus / Betacoronavirus spike glycoprotein S1, receptor binding / Spike glycoprotein S1, N-terminal domain, betacoronavirus-like / Betacoronavirus-like spike glycoprotein S1, N-terminal / Spike glycoprotein S2, coronavirus, heptad repeat 1 / Spike glycoprotein S2, coronavirus, heptad repeat 2 / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 2 (HR2) region profile. / Coronavirus spike (S) glycoprotein S2 subunit heptad repeat 1 (HR1) region profile. / Spike glycoprotein S2 superfamily, coronavirus / Spike glycoprotein S2, coronavirus / Coronavirus spike glycoprotein S2 / Coronavirus spike glycoprotein S1, C-terminal / Coronavirus spike glycoprotein S1, C-terminal Similarity search - Domain/homologyBiological species Severe acute respiratory syndrome coronavirus 2Lama glama (llama)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.011 Å DetailsAuthors Noland, C.L. / Pande, K. / Zhang, L. / Zhou, H. / Galli, J. / Eddins, M. / Gomez-Llorente, Y. Funding support 1items Details Hide detailsOrganization Grant number Country Other private
CitationJournal : Sci Rep / Year : 2023Title : Discovery and multimerization of cross-reactive single-domain antibodies against SARS-like viruses to enhance potency and address emerging SARS-CoV-2 variants.Authors: Hollingsworth, S.A. / Noland, C.L. / Vroom, K. / Saha, A. / Sam, M. / Gao, Q. / Zhou, H. / Grandy, D.U. / Singh, S. / Wen, Z. / Warren, C. / Ma, X.S. / Malashock, D. / Galli, J. / Go, G. / ... Authors : Hollingsworth, S.A. / Noland, C.L. / Vroom, K. / Saha, A. / Sam, M. / Gao, Q. / Zhou, H. / Grandy, D.U. / Singh, S. / Wen, Z. / Warren, C. / Ma, X.S. / Malashock, D. / Galli, J. / Go, G. / Eddins, M. / Mayhood, T. / Sathiyamoorthy, K. / Fridman, A. / Raoufi, F. / Gomez-Llorente, Y. / Patridge, A. / Tang, Y. / Chen, S.J. / Bailly, M. / Ji, C. / Kingsley, L.J. / Cheng, A.C. / Geierstanger, B.H. / Gorman, D.M. / Zhang, L. / Pande, K. History Deposition Apr 18, 2023 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Aug 16, 2023 Provider : repository / Type : Initial releaseRevision 1.1 Sep 6, 2023 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year
Show all Show less