Entry Database : PDB / ID : 8sbi Structure visualization Downloads & linksTitle Crystal structure of human sterol 14 alpha-demethylase (CYP51) in the ligand-free state ComponentsLanosterol 14-alpha demethylase Details Keywords OXIDOREDUCTASE / MONOOXYGENASE / CYTOCHROME P450 / ENDOPLASMIC RETICULUM / STEROL BIOSYNTHESISFunction / homology Function and homology informationFunction Domain/homology Component
sterol 14alpha-demethylase / sterol 14-demethylase activity / steroid 7-alpha-hydroxylase activity / oxysterol 7-alpha-hydroxylase activity / negative regulation of amyloid-beta clearance / sterol metabolic process / bile acid biosynthetic process / Cholesterol biosynthesis / EGR2 and SOX10-mediated initiation of Schwann cell myelination / steroid biosynthetic process ... sterol 14alpha-demethylase / sterol 14-demethylase activity / steroid 7-alpha-hydroxylase activity / oxysterol 7-alpha-hydroxylase activity / negative regulation of amyloid-beta clearance / sterol metabolic process / bile acid biosynthetic process / Cholesterol biosynthesis / EGR2 and SOX10-mediated initiation of Schwann cell myelination / steroid biosynthetic process / cholesterol biosynthetic process / negative regulation of protein secretion / Endogenous sterols / Activation of gene expression by SREBF (SREBP) / cholesterol homeostasis / negative regulation of protein catabolic process / oxidoreductase activity / iron ion binding / heme binding / endoplasmic reticulum membrane / membrane Similarity search - Function Cytochrome P450, E-class, group IV / Cytochrome P450, conserved site / Cytochrome P450 cysteine heme-iron ligand signature. / Cytochrome P450 / Cytochrome P450 superfamily / Cytochrome P450 Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.73 Å DetailsAuthors Hargrove, T.Y. / Wawrzak, Z. / Lepesheva, G.I. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) GM067871 United States
CitationJournal : To Be Published Title : Structural dynamics of sterol 14 alpha demethylases upon catalysisAuthors : Hargrove, T.Y. / Wawrzak, Z. / Lepesheva, G.I. History Deposition Apr 3, 2023 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Apr 12, 2023 Provider : repository / Type : Initial releaseRevision 1.1 May 22, 2024 Group : Data collection / Category : chem_comp_atom / chem_comp_bond
Show all Show less