Entry | Database: PDB / ID: 8s3x |
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Title | LIM Domain Kinase 2 (LIMK2) bound to compound 52 |
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Components | LIM domain kinase 2 |
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Keywords | TRANSFERASE / Kinase / Inhibitor / Actin cytoskeleton |
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Function / homology | Function and homology information
cornea development in camera-type eye / establishment of vesicle localization / head development / astral microtubule organization / negative regulation of cilium assembly / cis-Golgi network / RHO GTPases Activate ROCKs / Sema4D induced cell migration and growth-cone collapse / EPHB-mediated forward signaling / phosphorylation ...cornea development in camera-type eye / establishment of vesicle localization / head development / astral microtubule organization / negative regulation of cilium assembly / cis-Golgi network / RHO GTPases Activate ROCKs / Sema4D induced cell migration and growth-cone collapse / EPHB-mediated forward signaling / phosphorylation / mitotic spindle / positive regulation of protein localization to nucleus / actin cytoskeleton organization / spermatogenesis / non-specific serine/threonine protein kinase / positive regulation of protein phosphorylation / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / centrosome / perinuclear region of cytoplasm / ATP binding / nucleus / metal ion binding / cytoplasmSimilarity search - Function : / LIM zinc-binding domain signature. / LIM domain / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / LIM domain profile. / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain ...: / LIM zinc-binding domain signature. / LIM domain / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / LIM domain profile. / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamilySimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.59 Å |
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Authors | Mathea, S. / Chatterjee, D. / Preuss, F. / Ple, K. / Knapp, S. |
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Funding support | 1items Organization | Grant number | Country |
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Not funded | | |
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Citation | |
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History | Deposition | Feb 20, 2024 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Mar 6, 2024 | Provider: repository / Type: Initial release |
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