- PDB-8qqe: Crystal structure of the complex between DMC1 and the PhePP domai... -
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Basic information
Entry
Database: PDB / ID: 8qqe
Title
Crystal structure of the complex between DMC1 and the PhePP domain of BRCA2
Components
Breast cancer type 2 susceptibility protein
Meiotic recombination protein DMC1/LIM15 homolog
Keywords
RECOMBINATION / DNA BINDING PROTEIN / Meiotic recombination / RING PROTEIN / OCTAMER / AAA ATPASE
Function / homology
Function and homology information
BRCA2-MAGE-D1 complex / negative regulation of mammary gland epithelial cell proliferation / female gamete generation / mitotic recombination-dependent replication fork processing / chromosome organization involved in meiotic cell cycle / establishment of protein localization to telomere / Impaired BRCA2 translocation to the nucleus / Impaired BRCA2 binding to SEM1 (DSS1) / double-strand break repair involved in meiotic recombination / nuclear ubiquitin ligase complex ...BRCA2-MAGE-D1 complex / negative regulation of mammary gland epithelial cell proliferation / female gamete generation / mitotic recombination-dependent replication fork processing / chromosome organization involved in meiotic cell cycle / establishment of protein localization to telomere / Impaired BRCA2 translocation to the nucleus / Impaired BRCA2 binding to SEM1 (DSS1) / double-strand break repair involved in meiotic recombination / nuclear ubiquitin ligase complex / homologous chromosome pairing at meiosis / lateral element / telomere maintenance via recombination / DNA recombinase assembly / histone H4 acetyltransferase activity / histone H3 acetyltransferase activity / regulation of DNA damage checkpoint / mitotic recombination / Impaired BRCA2 binding to PALB2 / DNA strand invasion / HDR through MMEJ (alt-NHEJ) / gamma-tubulin binding / DNA strand exchange activity / reciprocal meiotic recombination / DNA repair complex / Defective homologous recombination repair (HRR) due to BRCA1 loss of function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function / Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function / oocyte maturation / Homologous DNA Pairing and Strand Exchange / Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) / response to UV-C / Resolution of D-loop Structures through Holliday Junction Intermediates / inner cell mass cell proliferation / ATP-dependent DNA damage sensor activity / DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator / hematopoietic stem cell proliferation / Impaired BRCA2 binding to RAD51 / female gonad development / male meiosis I / Presynaptic phase of homologous DNA pairing and strand exchange / centrosome duplication / spermatid development / response to X-ray / intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator / ATP-dependent activity, acting on DNA / ovarian follicle development / positive regulation of mitotic cell cycle / meiotic cell cycle / regulation of cytokinesis / condensed nuclear chromosome / secretory granule / cellular response to ionizing radiation / nucleotide-excision repair / response to gamma radiation / double-strand break repair via homologous recombination / HDR through Homologous Recombination (HRR) / brain development / Meiotic recombination / cellular senescence / double-strand break repair / chromosome / site of double-strand break / single-stranded DNA binding / spermatogenesis / double-stranded DNA binding / protease binding / chromosome, telomeric region / centrosome / regulation of DNA-templated transcription / positive regulation of DNA-templated transcription / ATP hydrolysis activity / protein-containing complex / DNA binding / nucleoplasm / ATP binding / identical protein binding / nucleus / cytosol Similarity search - Function
Meiotic recombination protein Dmc1 / : / BRCA2, OB2 / BRCA2, OB3 / Tower domain / Breast cancer type 2 susceptibility protein, helical domain / BRCA2 helical domain superfamily / BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 / Tower / BRCA2, helical ...Meiotic recombination protein Dmc1 / : / BRCA2, OB2 / BRCA2, OB3 / Tower domain / Breast cancer type 2 susceptibility protein, helical domain / BRCA2 helical domain superfamily / BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 / Tower / BRCA2, helical / Tower / BRCA2 repeat / BRCA2, OB1 / Breast cancer type 2 susceptibility protein / BRCA2 repeat / BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 / BRCA2 repeat profile. / DNA recombination and repair protein, RecA-like / DNA recombination and repair protein Rad51-like, C-terminal / Rad51 / DNA recombination and repair protein RecA, monomer-monomer interface / RecA family profile 2. / DNA recombination and repair protein RecA-like, ATP-binding domain / RecA family profile 1. / DNA repair Rad51/transcription factor NusA, alpha-helical / Helix-hairpin-helix domain / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / Nucleic acid-binding, OB-fold / P-loop containing nucleoside triphosphate hydrolase Similarity search - Domain/homology
Breast cancer type 2 susceptibility protein / Meiotic recombination protein DMC1/LIM15 homolog Similarity search - Component
A: Meiotic recombination protein DMC1/LIM15 homolog B: Meiotic recombination protein DMC1/LIM15 homolog C: Breast cancer type 2 susceptibility protein D: Breast cancer type 2 susceptibility protein hetero molecules
A: Meiotic recombination protein DMC1/LIM15 homolog B: Meiotic recombination protein DMC1/LIM15 homolog C: Breast cancer type 2 susceptibility protein D: Breast cancer type 2 susceptibility protein hetero molecules
A: Meiotic recombination protein DMC1/LIM15 homolog B: Meiotic recombination protein DMC1/LIM15 homolog C: Breast cancer type 2 susceptibility protein D: Breast cancer type 2 susceptibility protein hetero molecules
A: Meiotic recombination protein DMC1/LIM15 homolog B: Meiotic recombination protein DMC1/LIM15 homolog C: Breast cancer type 2 susceptibility protein D: Breast cancer type 2 susceptibility protein hetero molecules
A: Meiotic recombination protein DMC1/LIM15 homolog B: Meiotic recombination protein DMC1/LIM15 homolog C: Breast cancer type 2 susceptibility protein D: Breast cancer type 2 susceptibility protein hetero molecules
defined by author
Evidence: gel filtration, A dimer is observed in the asymmetric unit, which is assembled into a ring-shaped octamer using the crystallographic symmetries. Size Exclusion Chromatography coupled to ...Evidence: gel filtration, A dimer is observed in the asymmetric unit, which is assembled into a ring-shaped octamer using the crystallographic symmetries. Size Exclusion Chromatography coupled to Multi-Angle Light Scattering also shows that DMC1 bound to PhePP assembles into an octamer in solution.
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