- PDB-8q40: Crystal structure of cA4 activated Can2 in complex with a cleaved... -
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基本情報
登録情報
データベース: PDB / ID: 8q40
タイトル
Crystal structure of cA4 activated Can2 in complex with a cleaved DNA substrate
要素
Cyclic tetraadenosine monophosphate (cA4)
DNA (5'-D(*TP*CP*A)-3')
DUF1887 family protein
キーワード
DNA BINDING PROTEIN / Can2 / cyclic oligoadenylates / cA4 / CARF / CRISPR ancillary nuclease / Protein-DNA complex
機能・相同性
tRNA endonuclease-like domain superfamily / Restriction endonuclease type II-like / nucleic acid binding / metal ion binding / : / : / DNA / RNA / DUF1887 family protein
A: DUF1887 family protein B: DUF1887 family protein D: DNA (5'-D(*TP*CP*A)-3') C: DNA (5'-D(*TP*CP*A)-3') X: Cyclic tetraadenosine monophosphate (cA4) ヘテロ分子
タイプ: Polycyclic / クラス: Antiviral / 分子量: 1271.866 Da / 分子数: 1 / 由来タイプ: 合成 詳細: Cyclic oligoadenylates such as c-tetraAMP were found to be novel bacterial second messengers. Antiviral in context of signalling for Type III CRISPR-Cas systems. 由来: (合成) synthetic construct (人工物) / 参照: BIRD: PRD_002431
CRISPR-Cas systems provide bacteria with adaptive immunity against bacteriophages. Cyclic ...CRISPR-Cas systems provide bacteria with adaptive immunity against bacteriophages. Cyclic oligoadenylate signaling was found to be essential for the type III system against the jumbo phage.