- PDB-8q1z: Crystal Structure of Human Vaccinia-related kinase 2 (VRK-2) boun... -
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Basic information
Entry
Database: PDB / ID: 8q1z
Title
Crystal Structure of Human Vaccinia-related kinase 2 (VRK-2) bound to JA-296
Components
Serine/threonine-protein kinase VRK2
Keywords
TRANSFERASE / inhibitor / kinase / VRK2
Function / homology
Function and homology information
regulation of interleukin-1-mediated signaling pathway / Nuclear Envelope Breakdown / Initiation of Nuclear Envelope (NE) Reformation / RHOD GTPase cycle / regulation of MAPK cascade / RHOG GTPase cycle / RAC2 GTPase cycle / RAC3 GTPase cycle / RAC1 GTPase cycle / mitochondrial membrane ...regulation of interleukin-1-mediated signaling pathway / Nuclear Envelope Breakdown / Initiation of Nuclear Envelope (NE) Reformation / RHOD GTPase cycle / regulation of MAPK cascade / RHOG GTPase cycle / RAC2 GTPase cycle / RAC3 GTPase cycle / RAC1 GTPase cycle / mitochondrial membrane / nuclear envelope / cellular response to oxidative stress / protein autophosphorylation / non-specific serine/threonine protein kinase / protein domain specific binding / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / endoplasmic reticulum membrane / protein kinase binding / endoplasmic reticulum / signal transduction / protein-containing complex / ATP binding / nucleus / cytoplasm Similarity search - Function
Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homology
Mass: 36788.230 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Details: LIG is the compound that reversibly binds to VRK2 / Source: (gene. exp.) Homo sapiens (human) / Gene: VRK2 / Production host: Escherichia coli BL21(DE3) (bacteria) References: UniProt: Q86Y07, non-specific serine/threonine protein kinase