登録情報 | データベース: PDB / ID: 8q1r |
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タイトル | mouse Keap1 in complex with stapled peptide |
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要素 | - Kelch-like ECH-associated protein 1
- Stapled peptide
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キーワード | LIGASE / Keap1 / cyclic peptide / E3 ligase adaptor / antioxidant response |
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機能・相同性 | 機能・相同性情報
cellular response to carbohydrate stimulus / KEAP1-NFE2L2 pathway / regulation of epidermal cell differentiation / Neddylation / Antigen processing: Ubiquitination & Proteasome degradation / Ub-specific processing proteases / negative regulation of response to oxidative stress / Cul3-RING ubiquitin ligase complex / centriolar satellite / ubiquitin-like ligase-substrate adaptor activity ...cellular response to carbohydrate stimulus / KEAP1-NFE2L2 pathway / regulation of epidermal cell differentiation / Neddylation / Antigen processing: Ubiquitination & Proteasome degradation / Ub-specific processing proteases / negative regulation of response to oxidative stress / Cul3-RING ubiquitin ligase complex / centriolar satellite / ubiquitin-like ligase-substrate adaptor activity / cellular response to interleukin-4 / inclusion body / regulation of autophagy / actin filament / adherens junction / disordered domain specific binding / cellular response to oxidative stress / midbody / ubiquitin-dependent protein catabolic process / in utero embryonic development / RNA polymerase II-specific DNA-binding transcription factor binding / protein ubiquitination / negative regulation of gene expression / focal adhesion / regulation of DNA-templated transcription / endoplasmic reticulum / protein-containing complex / nucleoplasm / identical protein binding / cytosol / cytoplasm類似検索 - 分子機能 Kelch-like ECH-associated protein 1 / : / BTB-kelch protein / BTB/Kelch-associated / BTB And C-terminal Kelch / BTB And C-terminal Kelch / Kelch / Kelch repeat type 1 / Kelch motif / Kelch-type beta propeller ...Kelch-like ECH-associated protein 1 / : / BTB-kelch protein / BTB/Kelch-associated / BTB And C-terminal Kelch / BTB And C-terminal Kelch / Kelch / Kelch repeat type 1 / Kelch motif / Kelch-type beta propeller / BTB/POZ domain / BTB domain profile. / Broad-Complex, Tramtrack and Bric a brac / BTB/POZ domain / SKP1/BTB/POZ domain superfamily類似検索 - ドメイン・相同性 Chem-IZS / Kelch-like ECH-associated protein 1類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Mus musculus (ハツカネズミ) synthetic construct (人工物) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.33 Å |
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データ登録者 | Kack, H. / Wissler, L. |
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資金援助 | スウェーデン, 英国, チェコ, 5件 組織 | 認可番号 | 国 |
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Swedish Research Council | 2018-07152 | スウェーデン | UK Research and Innovation (UKRI) | | 英国 | Other government | 2019-02496 | スウェーデン | Other government | 22-07138O | チェコ | Other private | 22.39 | 英国 |
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引用 | ジャーナル: Chem Sci / 年: 2023 タイトル: A cell-active cyclic peptide targeting the Nrf2/Keap1 protein-protein interaction. 著者: Iegre, J. / Krajcovicova, S. / Gunnarsson, A. / Wissler, L. / Kack, H. / Luchniak, A. / Tangefjord, S. / Narjes, F. / Spring, D.R. |
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履歴 | 登録 | 2023年8月1日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2023年10月25日 | Provider: repository / タイプ: Initial release |
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