+Open data
-Basic information
Entry | Database: PDB / ID: 8pol | ||||||
---|---|---|---|---|---|---|---|
Title | Crystal structure of Plasmodium falciparum Sub1 protease | ||||||
Components | Subtilisin-like protease 1 | ||||||
Keywords | HYDROLASE / Protease / Plasmodium falciparum / merozoite egress / pH-dependent dimerization | ||||||
Function / homology | Function and homology information merozoite dense granule / exoneme / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / symbiont-containing vacuolar space / symbiont-containing vacuole / subtilisin / membrane protein ectodomain proteolysis / serine-type peptidase activity / protein processing / serine-type endopeptidase activity ...merozoite dense granule / exoneme / SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription / symbiont-containing vacuolar space / symbiont-containing vacuole / subtilisin / membrane protein ectodomain proteolysis / serine-type peptidase activity / protein processing / serine-type endopeptidase activity / proteolysis / membrane / metal ion binding Similarity search - Function | ||||||
Biological species | Plasmodium falciparum (malaria parasite P. falciparum) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.09 Å | ||||||
Authors | Martinez, M. / Bouillon, A. / Haouz, A. / Barale, J.C. / Alzari, P.M. | ||||||
Funding support | France, 1items
| ||||||
Citation | Journal: Mbio / Year: 2024 Title: Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress. Authors: Martinez, M. / Bouillon, A. / Brule, S. / Raynal, B. / Haouz, A. / Alzari, P.M. / Barale, J.-.C. | ||||||
History |
|
-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
---|
-Downloads & links
-Download
PDBx/mmCIF format | 8pol.cif.gz | 468.9 KB | Display | PDBx/mmCIF format |
---|---|---|---|---|
PDB format | pdb8pol.ent.gz | 321.1 KB | Display | PDB format |
PDBx/mmJSON format | 8pol.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 8pol_validation.pdf.gz | 453.1 KB | Display | wwPDB validaton report |
---|---|---|---|---|
Full document | 8pol_full_validation.pdf.gz | 460.6 KB | Display | |
Data in XML | 8pol_validation.xml.gz | 33 KB | Display | |
Data in CIF | 8pol_validation.cif.gz | 44.8 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/po/8pol ftp://data.pdbj.org/pub/pdb/validation_reports/po/8pol | HTTPS FTP |
-Related structure data
Similar structure data | Similarity search - Function & homologyF&H Search |
---|
-Links
-Assembly
Deposited unit |
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 |
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Unit cell |
| |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: ens_1
|