Entry Database : PDB / ID : 8pod Structure visualization Downloads & linksTitle Crystal structure of the kinase domain of ACVR1 (ALK2) in complex with FKBP12 and MU1700 ComponentsActivin receptor type-1 Peptidyl-prolyl cis-trans isomerase FKBP1A DetailsKeywords SIGNALING PROTEIN / ALK2 / FKBP12 / ACVR1 / kinase / complex / inhibitorFunction / homology Function and homology informationFunction Domain/homology Component
endocardial cushion cell fate commitment / mitral valve morphogenesis / endocardial cushion fusion / BMP receptor complex / atrial septum primum morphogenesis / macrolide binding / BMP receptor activity / cardiac muscle cell fate commitment / acute inflammatory response / activin receptor binding ... endocardial cushion cell fate commitment / mitral valve morphogenesis / endocardial cushion fusion / BMP receptor complex / atrial septum primum morphogenesis / macrolide binding / BMP receptor activity / cardiac muscle cell fate commitment / acute inflammatory response / activin receptor binding / activin receptor activity, type I / positive regulation of cardiac epithelial to mesenchymal transition / cytoplasmic side of membrane / positive regulation of determination of dorsal identity / transforming growth factor beta receptor activity, type I / activin receptor complex / endocardial cushion formation / smooth muscle cell differentiation / signaling receptor inhibitor activity / transforming growth factor beta receptor binding / TGFBR1 LBD Mutants in Cancer / receptor protein serine/threonine kinase / transmembrane receptor protein serine/threonine kinase activity / pharyngeal system development / activin binding / type I transforming growth factor beta receptor binding / cellular response to BMP stimulus / activin receptor signaling pathway / negative regulation of activin receptor signaling pathway / heart trabecula formation / transforming growth factor beta binding / embryonic heart tube morphogenesis / terminal cisterna / ryanodine receptor complex / gastrulation with mouth forming second / I-SMAD binding / dorsal/ventral pattern formation / regulation of amyloid precursor protein catabolic process / determination of left/right symmetry / neural crest cell migration / atrioventricular valve morphogenesis / protein maturation by protein folding / ventricular cardiac muscle tissue morphogenesis / 'de novo' protein folding / branching involved in blood vessel morphogenesis / negative regulation of G1/S transition of mitotic cell cycle / negative regulation of phosphoprotein phosphatase activity / ventricular septum morphogenesis / FK506 binding / mTORC1-mediated signalling / SMAD binding / TGF-beta receptor signaling activates SMADs / germ cell development / peptide hormone binding / positive regulation of SMAD protein signal transduction / Calcineurin activates NFAT / mesoderm formation / regulation of immune response / regulation of ossification / positive regulation of bone mineralization / BMP signaling pathway / positive regulation of osteoblast differentiation / protein peptidyl-prolyl isomerization / negative regulation of signal transduction / supramolecular fiber organization / heart morphogenesis / regulation of ryanodine-sensitive calcium-release channel activity / sarcoplasmic reticulum membrane / T cell activation / transforming growth factor beta receptor signaling pathway / protein tyrosine kinase binding / TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) / peptidylprolyl isomerase / sarcoplasmic reticulum / peptidyl-prolyl cis-trans isomerase activity / negative regulation of extrinsic apoptotic signaling pathway / calcium ion transmembrane transport / negative regulation of transforming growth factor beta receptor signaling pathway / cellular response to growth factor stimulus / Z disc / SARS-CoV-1 activates/modulates innate immune responses / regulation of protein localization / positive regulation of peptidyl-tyrosine phosphorylation / protein folding / positive regulation of protein binding / apical part of cell / heart development / protein refolding / positive regulation of canonical NF-kappaB signal transduction / in utero embryonic development / transmembrane transporter binding / amyloid fibril formation / Potential therapeutics for SARS / protein kinase activity / positive regulation of cell migration / cadherin binding / phosphorylation / protein serine/threonine kinase activity / positive regulation of DNA-templated transcription / protein homodimerization activity Similarity search - Function GS domain / Transforming growth factor beta type I GS-motif / GS domain profile. / GS motif / Activin types I and II receptor domain / Activin types I and II receptor domain / Ser/Thr protein kinase, TGFB receptor / Snake toxin-like superfamily / FKBP-type peptidyl-prolyl cis-trans isomerase domain profile. / FKBP-type peptidyl-prolyl cis-trans isomerase domain ... GS domain / Transforming growth factor beta type I GS-motif / GS domain profile. / GS motif / Activin types I and II receptor domain / Activin types I and II receptor domain / Ser/Thr protein kinase, TGFB receptor / Snake toxin-like superfamily / FKBP-type peptidyl-prolyl cis-trans isomerase domain profile. / FKBP-type peptidyl-prolyl cis-trans isomerase domain / FKBP-type peptidyl-prolyl cis-trans isomerase / Peptidyl-prolyl cis-trans isomerase domain superfamily / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.59 Å DetailsAuthors Cros, J. / Baltanas-Copado, J. / Knapp, S. / Paruch, K. / Nemec, N. / Bullock, A.N. Funding support Switzerland, 1items Details Hide detailsOrganization Grant number Country Innovative Medicines Initiative Switzerland
CitationJournal : To Be Published Title : Crystal structure of the kinase domain of ACVR1 (ALK2) in complex with FKBP12 and MU1700Authors : Cros, J. / Baltanas-Copado, J. / Bullock, A.N. History Deposition Jul 4, 2023 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jun 19, 2024 Provider : repository / Type : Initial release