Entry Database : PDB / ID : 8oyp Structure visualization Downloads & linksTitle Crystal structure of Ubiquitin specific protease 11 (USP11) in complex with a substrate mimetic ComponentsPolyubiquitin-B Ubiquitin carboxyl-terminal hydrolase 11,Response regulator FrzS DetailsKeywords HYDROLASE / Protease / Ubiquitin / Substrate complex / Deubiquitinating enzymeFunction / homology Function and homology informationFunction Domain/homology Component
symbiont entry into host cell via disruption of host cell glycocalyx / symbiont entry into host cell via disruption of host cell envelope / virus tail / Association of TriC/CCT with target proteins during biosynthesis / protein deubiquitination / phosphorelay signal transduction system / transcription corepressor binding / chromosome / ubiquitinyl hydrolase 1 / cysteine-type deubiquitinase activity ... symbiont entry into host cell via disruption of host cell glycocalyx / symbiont entry into host cell via disruption of host cell envelope / virus tail / Association of TriC/CCT with target proteins during biosynthesis / protein deubiquitination / phosphorelay signal transduction system / transcription corepressor binding / chromosome / ubiquitinyl hydrolase 1 / cysteine-type deubiquitinase activity / Ub-specific processing proteases / cysteine-type endopeptidase activity / proteolysis / nucleoplasm / nucleus / cytosol Similarity search - Function Ubiquitin-like domain, USP-type / Ubiquitin-like domain / Peptidase C19, ubiquitin-specific peptidase, DUSP domain / DUSP-like superfamily / DUSP domain / DUSP domain profile. / Domain in ubiquitin-specific proteases. / : / Ubiquitin carboxyl-terminal hydrolase, C-terminal / Ubiquitin-specific protease C-terminal ... Ubiquitin-like domain, USP-type / Ubiquitin-like domain / Peptidase C19, ubiquitin-specific peptidase, DUSP domain / DUSP-like superfamily / DUSP domain / DUSP domain profile. / Domain in ubiquitin-specific proteases. / : / Ubiquitin carboxyl-terminal hydrolase, C-terminal / Ubiquitin-specific protease C-terminal / : / Ubiquitin specific protease (USP) domain signature 2. / Ubiquitin specific protease (USP) domain signature 1. / Ubiquitin specific protease, conserved site / Peptidase C19, ubiquitin carboxyl-terminal hydrolase / Ubiquitin carboxyl-terminal hydrolase / Ubiquitin specific protease domain / Ubiquitin specific protease (USP) domain profile. / Pectate lyase superfamily protein / Rhamnogalacturonase A/epimerase, pectate lyase-like / Response regulator receiver domain / cheY-homologous receiver domain / Pectin lyase fold / Signal transduction response regulator, receiver domain / Response regulatory domain profile. / CheY-like superfamily / Pectin lyase fold/virulence factor / Papain-like cysteine peptidase superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.44 Å DetailsAuthors Maurer, S.K. / Caulton, S.G. / Ward, S.J. / Emsley, J. / Dreveny, I. Funding support United Kingdom, 2items Details Hide detailsOrganization Grant number Country Biotechnology and Biological Sciences Research Council (BBSRC) BB/H012656/1 United Kingdom Biotechnology and Biological Sciences Research Council (BBSRC) BB/M008770/1 United Kingdom
CitationJournal : J.Biol.Chem. / Year : 2023Title : Ubiquitin-specific protease 11 structure in complex with an engineered substrate mimetic reveals a molecular feature for deubiquitination selectivity.Authors : Maurer, S.K. / Mayer, M.P. / Ward, S.J. / Boudjema, S. / Halawa, M. / Zhang, J. / Caulton, S.G. / Emsley, J. / Dreveny, I. History Deposition May 5, 2023 Deposition site : PDBE / Processing site : PDBERevision 1.0 Oct 18, 2023 Provider : repository / Type : Initial releaseRevision 1.1 Nov 15, 2023 Group : Database references / Category : citation / Item : _citation.journal_volume / _citation.title
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