登録情報 | データベース: PDB / ID: 8os0 |
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タイトル | Solution NMR structure of Notch3 WT TMD |
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要素 | Notch 3 extracellular truncation |
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キーワード | MEMBRANE PROTEIN / Notch3 WT / gamma secretase / transmembrane |
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機能・相同性 | 機能・相同性情報
glomerular capillary formation / Defective LFNG causes SCDO3 / Pre-NOTCH Processing in the Endoplasmic Reticulum / Noncanonical activation of NOTCH3 / neuroblast differentiation / Pre-NOTCH Processing in Golgi / neuron fate commitment / Notch binding / NOTCH3 Intracellular Domain Regulates Transcription / artery morphogenesis ...glomerular capillary formation / Defective LFNG causes SCDO3 / Pre-NOTCH Processing in the Endoplasmic Reticulum / Noncanonical activation of NOTCH3 / neuroblast differentiation / Pre-NOTCH Processing in Golgi / neuron fate commitment / Notch binding / NOTCH3 Intracellular Domain Regulates Transcription / artery morphogenesis / Notch-HLH transcription pathway / negative regulation of neuron differentiation / forebrain development / Notch signaling pathway / NOTCH3 Activation and Transmission of Signal to the Nucleus / positive regulation of smooth muscle cell proliferation / axon guidance / Pre-NOTCH Transcription and Translation / positive regulation of miRNA transcription / signaling receptor activity / receptor complex / cadherin binding / Golgi membrane / calcium ion binding / endoplasmic reticulum membrane / enzyme binding / negative regulation of transcription by RNA polymerase II / cell surface / positive regulation of transcription by RNA polymerase II / extracellular region / nucleoplasm / identical protein binding / plasma membrane / cytosol類似検索 - 分子機能 Neurogenic locus Notch 3 / Notch, C-terminal / Domain of unknown function / Notch / Notch, NOD domain / Notch, NODP domain / NOTCH protein / NOTCH protein / NOD / NODP ...Neurogenic locus Notch 3 / Notch, C-terminal / Domain of unknown function / Notch / Notch, NOD domain / Notch, NODP domain / NOTCH protein / NOTCH protein / NOD / NODP / Notch-like domain superfamily / LNR (Lin-12/Notch) repeat profile. / LNR domain / Notch domain / Domain found in Notch and Lin-12 / EGF-like, conserved site / Human growth factor-like EGF / : / Calcium-binding EGF domain / Ankyrin repeats (many copies) / EGF-like domain / EGF-type aspartate/asparagine hydroxylation site / EGF-like calcium-binding, conserved site / Calcium-binding EGF-like domain signature. / Aspartic acid and asparagine hydroxylation site. / EGF-like calcium-binding domain / Calcium-binding EGF-like domain / Epidermal growth factor-like domain. / Ankyrin repeat / EGF-like domain profile. / Growth factor receptor cysteine-rich domain superfamily / EGF-like domain signature 2. / EGF-like domain signature 1. / EGF-like domain / Ankyrin repeats (3 copies) / Ankyrin repeat profile. / Ankyrin repeat region circular profile. / ankyrin repeats / Ankyrin repeat / Ankyrin repeat-containing domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 溶液NMR / simulated annealing |
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データ登録者 | Guschtschin-Schmidt, N. / Muhle-Goll, C. |
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資金援助 | ドイツ, 1件 組織 | 認可番号 | 国 |
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German Research Foundation (DFG) | FOR2290 | ドイツ |
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引用 | ジャーナル: J.Mol.Biol. / 年: 2023 タイトル: Permissive Conformations of a Transmembrane Helix Allow Intramembrane Proteolysis by gamma-Secretase. 著者: Ortner, M. / Guschtschin-Schmidt, N. / Stelzer, W. / Muhle-Goll, C. / Langosch, D. |
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履歴 | 登録 | 2023年4月17日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2023年8月16日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年8月23日 | Group: Database references / カテゴリ: citation / Item: _citation.journal_volume |
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