Entry | Database: PDB / ID: 8omv |
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Title | Crystal structure of the constitutively active S117E/S181E mutant of human IKK2 |
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Components | Inhibitor of nuclear factor kappa-B kinase subunit beta |
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Keywords | TRANSFERASE / IKK / NF-kappaB / IkBa / docking |
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Function / homology | Function and homology information
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent / IkappaB kinase / IkappaB kinase activity / IKBKB deficiency causes SCID / IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) / IkappaB kinase complex / negative regulation of myosin-light-chain-phosphatase activity / negative regulation of bicellular tight junction assembly / transferrin receptor binding / IkBA variant leads to EDA-ID ...antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent / IkappaB kinase / IkappaB kinase activity / IKBKB deficiency causes SCID / IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) / IkappaB kinase complex / negative regulation of myosin-light-chain-phosphatase activity / negative regulation of bicellular tight junction assembly / transferrin receptor binding / IkBA variant leads to EDA-ID / toll-like receptor 3 signaling pathway / CD40 receptor complex / TRIF-dependent toll-like receptor signaling pathway / NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 / RIP-mediated NFkB activation via ZBP1 / regulation of phosphorylation / regulation of establishment of endothelial barrier / regulation of tumor necrosis factor-mediated signaling pathway / MyD88-dependent toll-like receptor signaling pathway / interleukin-1-mediated signaling pathway / cortical actin cytoskeleton organization / stimulatory C-type lectin receptor signaling pathway / Fc-epsilon receptor signaling pathway / TRAF6 mediated NF-kB activation / protein maturation / canonical NF-kappaB signal transduction / stress-activated MAPK cascade / IRAK1 recruits IKK complex / IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation / tumor necrosis factor-mediated signaling pathway / p75NTR recruits signalling complexes / NF-kB is activated and signals survival / MAP3K8 (TPL2)-dependent MAPK1/3 activation / TICAM1, RIP1-mediated IKK complex recruitment / IKK complex recruitment mediated by RIP1 / TNFR1-induced NF-kappa-B signaling pathway / Regulation of NF-kappa B signaling / protein localization to plasma membrane / Activation of NF-kappaB in B cells / Regulation of TNFR1 signaling / TAK1-dependent IKK and NF-kappa-B activation / NOD1/2 Signaling Pathway / response to virus / PKR-mediated signaling / cytoplasmic side of plasma membrane / CLEC7A (Dectin-1) signaling / FCERI mediated NF-kB activation / Interleukin-1 signaling / Downstream TCR signaling / cellular response to tumor necrosis factor / positive regulation of NF-kappaB transcription factor activity / T cell receptor signaling pathway / ER-Phagosome pathway / scaffold protein binding / peptidyl-serine phosphorylation / positive regulation of canonical NF-kappaB signal transduction / non-specific serine/threonine protein kinase / protein kinase activity / inflammatory response / membrane raft / protein heterodimerization activity / protein phosphorylation / innate immune response / protein serine kinase activity / protein serine/threonine kinase activity / protein kinase binding / SARS-CoV-2 activates/modulates innate and adaptive immune responses / positive regulation of DNA-templated transcription / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / ATP binding / identical protein binding / nucleus / cytoplasm / cytosolSimilarity search - Function I-kappa-kinase-beta NEMO binding domain / IKBKB, scaffold dimerization domain / IKBKB, scaffold dimerization domain superfamily / I-kappa-kinase-beta NEMO binding domain / IQBAL scaffold dimerization domain / I-kappa-kinase-beta NEMO binding domain / Ubiquitin-like domain / Ubiquitin-like domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. ...I-kappa-kinase-beta NEMO binding domain / IKBKB, scaffold dimerization domain / IKBKB, scaffold dimerization domain superfamily / I-kappa-kinase-beta NEMO binding domain / IQBAL scaffold dimerization domain / I-kappa-kinase-beta NEMO binding domain / Ubiquitin-like domain / Ubiquitin-like domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamilySimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 4.16 Å |
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Authors | McEwen, A.G. / Li, C. / Moro, S. / Poussin-Courmontagne, P. / Zanier, K. |
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Funding support | France, 3items Organization | Grant number | Country |
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Instruct-ERIC Center (Strasbourg Centre) | PID: 11382 | France | Agence Nationale de la Recherche (ANR) | ANR-13-JSV8-0004-01 | France | French Infrastructure for Integrated Structural Biology (FRISBI) | ANR-10-INSB-05-01 | France |
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Citation | Journal: To be published Title: A novel YDD(phi)X(phi) linear motif mediates docking of IKK catalytic dimers to NF-kappaB substrates: structural and functional insights Authors: Li, C. / Moro, S. / Shastak, K. / O'Reily, F. / Donzeau, M. / Graziadei, A. / McEwen, A.G. / Poussin-Courmontagne, P. / Bachelart, T. / Fiskin, M. / Berrodier, N. / Orfanoudakis, G. / ...Authors: Li, C. / Moro, S. / Shastak, K. / O'Reily, F. / Donzeau, M. / Graziadei, A. / McEwen, A.G. / Poussin-Courmontagne, P. / Bachelart, T. / Fiskin, M. / Berrodier, N. / Orfanoudakis, G. / Poterszman, A. / Torbeev, V. / Rappsilber, J. / Davy, N. / Chariot, A. / Zanier, K. |
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History | Deposition | Mar 31, 2023 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Apr 10, 2024 | Provider: repository / Type: Initial release |
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