Entry | Database: PDB / ID: 8oeg |
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Title | PDE4B bound to MAPI compound 92a |
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Components | cAMP-specific 3',5'-cyclic phosphodiesterase 4B |
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Keywords | HYDROLASE / HUMAN PHOSPHODIESTERASE 4B / MAPI COMPOUND |
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Function / homology | Function and homology information
negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway / gamma-tubulin complex / negative regulation of relaxation of cardiac muscle / 3',5'-cyclic-AMP phosphodiesterase / neutrophil homeostasis / gamma-tubulin binding / regulation of cardiac muscle cell contraction / regulation of calcium ion transmembrane transport via high voltage-gated calcium channel / voltage-gated calcium channel complex / leukocyte migration ...negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway / gamma-tubulin complex / negative regulation of relaxation of cardiac muscle / 3',5'-cyclic-AMP phosphodiesterase / neutrophil homeostasis / gamma-tubulin binding / regulation of cardiac muscle cell contraction / regulation of calcium ion transmembrane transport via high voltage-gated calcium channel / voltage-gated calcium channel complex / leukocyte migration / cAMP catabolic process / excitatory synapse / DARPP-32 events / calcium channel regulator activity / 3',5'-cyclic-GMP phosphodiesterase activity / 3',5'-cyclic-AMP phosphodiesterase activity / cAMP binding / cellular response to epinephrine stimulus / positive regulation of interleukin-2 production / cAMP-mediated signaling / neutrophil chemotaxis / Z disc / positive regulation of type II interferon production / cellular response to xenobiotic stimulus / synaptic vesicle / T cell receptor signaling pathway / cellular response to lipopolysaccharide / transmembrane transporter binding / dendritic spine / postsynaptic density / centrosome / perinuclear region of cytoplasm / nucleus / metal ion binding / cytosolSimilarity search - Function Phosphodiesterase 4 upstream conserved regions (UCR) / Phosphodiesterase 4 upstream conserved regions (UCR) / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain / 3'5'-cyclic nucleotide phosphodiesterase, conserved site / 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily / 3'5'-cyclic nucleotide phosphodiesterase / 3'5'-cyclic nucleotide phosphodiesterase domain signature. / 3'5'-cyclic nucleotide phosphodiesterase domain profile. / Metal dependent phosphohydrolases with conserved 'HD' motif. / HD/PDEase domainSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.89 Å |
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Authors | Rizzi, A. / Armani, E. |
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Funding support | 1items Organization | Grant number | Country |
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Not funded | | |
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Citation | Journal: J.Med.Chem. / Year: 2023 Title: Optimization of M 3 Antagonist-PDE4 Inhibitor (MAPI) Dual Pharmacology Molecules for the Treatment of COPD. Authors: Rizzi, A. / Amari, G. / Pivetti, F. / Delcanale, M. / Amadei, F. / Pappani, A. / Fornasari, L. / Villetti, G. / Marchini, G. / Pisano, A.R. / Pitozzi, V. / Pittelli, M.G. / Trevisani, M. / ...Authors: Rizzi, A. / Amari, G. / Pivetti, F. / Delcanale, M. / Amadei, F. / Pappani, A. / Fornasari, L. / Villetti, G. / Marchini, G. / Pisano, A.R. / Pitozzi, V. / Pittelli, M.G. / Trevisani, M. / Salvadori, M. / Cenacchi, V. / Fioni, A. / Puccini, P. / Civelli, M. / Patacchini, R. / Baker-Glenn, C. / Van de Poel, H. / Blackaby, W. / Nash, K. / Armani, E. |
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History | Deposition | Mar 10, 2023 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Apr 26, 2023 | Provider: repository / Type: Initial release |
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Revision 1.1 | Nov 1, 2023 | Group: Data collection / Database references Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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Revision 1.2 | Nov 8, 2023 | Group: Database references / Category: citation Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title |
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