Entry Database : PDB / ID : 8kdx Structure visualization Downloads & linksTitle Tau-S214 Phosphorylation Inhibits Fyn Kinase Interaction and Increases the Decay Time of NMDAR-mediated Current ComponentsMicrotubule-associated protein tau Tyrosine-protein kinase Fyn DetailsKeywords PEPTIDE BINDING PROTEIN / Alzheimer's disease / Fyn Kinase / SH3 Domain / Tau Protein and PXXP motif.Function / homology Function and homology informationFunction Domain/homology Component
response to singlet oxygen / Reelin signalling pathway / negative regulation of hydrogen peroxide biosynthetic process / perinuclear endoplasmic reticulum / NTRK2 activates RAC1 / growth factor receptor binding / Activated NTRK2 signals through FYN / heart process / cellular response to L-glutamate / regulation of glutamate receptor signaling pathway ... response to singlet oxygen / Reelin signalling pathway / negative regulation of hydrogen peroxide biosynthetic process / perinuclear endoplasmic reticulum / NTRK2 activates RAC1 / growth factor receptor binding / Activated NTRK2 signals through FYN / heart process / cellular response to L-glutamate / regulation of glutamate receptor signaling pathway / regulation of calcium ion import across plasma membrane / SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion / G protein-coupled glutamate receptor signaling pathway / Platelet Adhesion to exposed collagen / CD28 co-stimulation / positive regulation of protein localization to membrane / activated T cell proliferation / CRMPs in Sema3A signaling / positive regulation of cysteine-type endopeptidase activity / FLT3 signaling through SRC family kinases / negative regulation of dendritic spine maintenance / feeding behavior / Nef and signal transduction / type 5 metabotropic glutamate receptor binding / Nephrin family interactions / dendrite morphogenesis / DCC mediated attractive signaling / EPH-Ephrin signaling / CD28 dependent Vav1 pathway / Ephrin signaling / plus-end-directed organelle transport along microtubule / dendritic spine maintenance / axonal transport / histone-dependent DNA binding / neurofibrillary tangle assembly / positive regulation of diacylglycerol kinase activity / negative regulation of establishment of protein localization to mitochondrion / neurofibrillary tangle / positive regulation of protein localization to synapse / microtubule lateral binding / tubulin complex / phosphatidylinositol bisphosphate binding / main axon / regulation of long-term synaptic depression / negative regulation of kinase activity / negative regulation of tubulin deacetylation / Regulation of KIT signaling / generation of neurons / regulation of chromosome organization / tau-protein kinase activity / positive regulation of protein localization / CTLA4 inhibitory signaling / rRNA metabolic process / internal protein amino acid acetylation / leukocyte migration / phospholipase activator activity / Fc-gamma receptor signaling pathway involved in phagocytosis / EPHA-mediated growth cone collapse / regulation of mitochondrial fission / intracellular distribution of mitochondria / cellular response to platelet-derived growth factor stimulus / axonal transport of mitochondrion / axon development / Dectin-2 family / central nervous system neuron development / regulation of microtubule polymerization / microtubule polymerization / minor groove of adenine-thymine-rich DNA binding / lipoprotein particle binding / stimulatory C-type lectin receptor signaling pathway / PECAM1 interactions / dynactin binding / CD28 dependent PI3K/Akt signaling / apolipoprotein binding / phospholipase binding / response to amyloid-beta / glial cell projection / negative regulation of mitochondrial membrane potential / Sema3A PAK dependent Axon repulsion / cellular response to glycine / FCGR activation / protein polymerization / alpha-tubulin binding / negative regulation of mitochondrial fission / EPH-ephrin mediated repulsion of cells / axolemma / positive regulation of protein targeting to membrane / ephrin receptor signaling pathway / Caspase-mediated cleavage of cytoskeletal proteins / regulation of microtubule polymerization or depolymerization / Role of LAT2/NTAL/LAB on calcium mobilization / positive regulation of axon extension / vascular endothelial growth factor receptor signaling pathway / detection of mechanical stimulus involved in sensory perception of pain / regulation of microtubule cytoskeleton organization / Activation of AMPK downstream of NMDARs / negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / supramolecular fiber organization / regulation of cellular response to heat / stress granule assembly Similarity search - Function : / Fyn/Yrk, SH3 domain / : / Microtubule associated protein, tubulin-binding repeat / Microtubule-associated protein Tau / Tau and MAP protein, tubulin-binding repeat / Tau and MAP proteins tubulin-binding repeat signature. / Tau and MAP proteins tubulin-binding repeat profile. / SH3 domain / SH2 domain ... : / Fyn/Yrk, SH3 domain / : / Microtubule associated protein, tubulin-binding repeat / Microtubule-associated protein Tau / Tau and MAP protein, tubulin-binding repeat / Tau and MAP proteins tubulin-binding repeat signature. / Tau and MAP proteins tubulin-binding repeat profile. / SH3 domain / SH2 domain / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2 domain / Src homology 3 domains / SH2 domain superfamily / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.01 Å DetailsAuthors Padavattan, S. / Jos, S. Funding support India, 1items Details Hide detailsOrganization Grant number Country Not funded India
CitationJournal : J.Mol.Biol. / Year : 2024Title : Tau-S214 Phosphorylation Inhibits Fyn Kinase Interaction and Increases the Decay Time of NMDAR-mediated Current.Authors : Jos, S. / Poulose, R. / Kambaru, A. / Gogoi, H. / Dalavaikodihalli Nanjaiah, N. / Padmanabhan, B. / Mehta, B. / Padavattan, S. History Deposition Aug 10, 2023 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Feb 28, 2024 Provider : repository / Type : Initial release