- PDB-8j0k: Crystal structure of human TFAP2A in complex with DNA -
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Basic information
Entry
Database: PDB / ID: 8j0k
Title
Crystal structure of human TFAP2A in complex with DNA
Components
DNA (5'-D(*CP*TP*GP*CP*CP*TP*CP*GP*GP*GP*CP*AP*C)-3')
DNA (5'-D(*GP*TP*GP*CP*CP*CP*GP*AP*GP*GP*CP*AP*G)-3')
Transcription factor AP-2-alpha
Keywords
DNA BINDING PROTEIN/DNA / TFAP2A-DNA complex / DNA BINDING PROTEIN-DNA complex
Function / homology
Function and homology information
optic vesicle morphogenesis / optic cup structural organization / oculomotor nerve formation / positive regulation of tooth mineralization / nuclear receptor corepressor activity / trigeminal nerve development / TFAP2 (AP-2) family regulates transcription of other transcription factors / TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation / retina layer formation / Specification of the neural plate border ...optic vesicle morphogenesis / optic cup structural organization / oculomotor nerve formation / positive regulation of tooth mineralization / nuclear receptor corepressor activity / trigeminal nerve development / TFAP2 (AP-2) family regulates transcription of other transcription factors / TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation / retina layer formation / Specification of the neural plate border / TFAP2 (AP-2) family regulates transcription of cell cycle factors / Negative regulation of activity of TFAP2 (AP-2) family transcription factors / Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors / negative regulation of transcription by competitive promoter binding / embryonic cranial skeleton morphogenesis / Activation of the TFAP2 (AP-2) family of transcription factors / bone morphogenesis / embryonic forelimb morphogenesis / inner ear morphogenesis / regulation of cell differentiation / roof of mouth development / eyelid development in camera-type eye / SUMOylation of transcription factors / negative regulation of reactive oxygen species metabolic process / positive regulation of bone mineralization / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / kidney development / cellular response to iron ion / RNA polymerase II transcription regulatory region sequence-specific DNA binding / sensory perception of sound / DNA-binding transcription repressor activity, RNA polymerase II-specific / positive regulation of neuron apoptotic process / sequence-specific double-stranded DNA binding / regulation of cell population proliferation / DNA-binding transcription activator activity, RNA polymerase II-specific / sequence-specific DNA binding / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / negative regulation of cell population proliferation / negative regulation of DNA-templated transcription / chromatin binding / positive regulation of gene expression / negative regulation of apoptotic process / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / DNA binding / nucleoplasm / identical protein binding / nucleus Similarity search - Function