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- PDB-8iyj: Cryo-EM structure of the 48-nm repeat doublet microtubule from mo... -

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データベース: PDB / ID: 8iyj
タイトルCryo-EM structure of the 48-nm repeat doublet microtubule from mouse sperm
要素
  • (Cilia- and flagella-associated protein ...) x 12
  • (EF-hand domain-containing family member ...) x 2
  • (Piercer of microtubule wall ...) x 2
  • (RIB43A-like with coiled-coils protein ...) x 2
  • (Testis-expressed ...) x 2
  • Cilia and flagella-associated protein 77
  • Coiled-coil domain-containing protein 105
  • Dual specificity phosphatase 21
  • EF-hand calcium-binding domain-containing protein 6
  • EF-hand domain-containing protein 1
  • Enkurin
  • Family with sequence similarity 183, member B
  • Meiosis-specific nuclear structural protein 1
  • Nucleoside diphosphate kinase 7
  • Outer dense fiber protein 3
  • Parkin coregulated gene protein homolog
  • Protein FAM166A
  • Protein FAM166C
  • Protein Flattop
  • Protein phosphatase 1 regulatory subunit 32
  • Sperm-associated antigen 8
  • Spermatid-specific manchette-related protein 1
  • Tektin bundle-interacting protein 1
  • Tektin-1
  • Tektin-2
  • Tektin-3
  • Tektin-4
  • Tektin-5
  • Testis expressed 49
  • Testis, prostate and placenta-expressed protein
  • Testis-specific serine/threonine-protein kinase 6
  • Tubulin alpha-3 chain
  • Tubulin beta-4B chain
  • Uncharacterized protein C10orf82 homolog
キーワードSTRUCTURAL PROTEIN / doublet microtubule
機能・相同性
機能・相同性情報


male germ-line stem cell population maintenance / outer dense fiber / left/right pattern formation / axonemal microtubule doublet inner sheath / Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane / Cilium Assembly / Sealing of the nuclear envelope (NE) by ESCRT-III / outer acrosomal membrane / epithelial cilium movement involved in determination of left/right asymmetry / regulation of brood size ...male germ-line stem cell population maintenance / outer dense fiber / left/right pattern formation / axonemal microtubule doublet inner sheath / Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane / Cilium Assembly / Sealing of the nuclear envelope (NE) by ESCRT-III / outer acrosomal membrane / epithelial cilium movement involved in determination of left/right asymmetry / regulation of brood size / establishment of left/right asymmetry / 9+0 motile cilium / protein localization to motile cilium / sperm flagellum assembly / manchette assembly / axonemal B tubule inner sheath / axonemal A tubule inner sheath / Intraflagellar transport / manchette / Carboxyterminal post-translational modifications of tubulin / sperm axoneme assembly / protein polyglutamylation / inner dynein arm assembly / regulation of calcineurin-NFAT signaling cascade / positive regulation of feeding behavior / regulation of microtubule nucleation / COPI-independent Golgi-to-ER retrograde traffic / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / MAP kinase tyrosine/serine/threonine phosphatase activity / cerebrospinal fluid circulation / sperm principal piece / regulation of cilium beat frequency involved in ciliary motility / epithelial cilium movement involved in extracellular fluid movement / cilium movement involved in cell motility / protein localization to organelle / COPI-mediated anterograde transport / Aggrephagy / regulation of store-operated calcium entry / 転移酵素; リンを含む基を移すもの / 9+2 motile cilium / Kinesins / intraciliary transport / Mitotic Prometaphase / EML4 and NUDC in mitotic spindle formation / acrosomal membrane / microtubule sliding / Resolution of Sister Chromatid Cohesion / PKR-mediated signaling / The role of GTSE1 in G2/M progression after G2 checkpoint / ciliary transition zone / cilium movement / RHO GTPases activate IQGAPs / Recycling pathway of L1 / axoneme assembly / left/right axis specification / COPI-dependent Golgi-to-ER retrograde traffic / sperm DNA condensation / calcium ion sensor activity / RHO GTPases Activate Formins / axonemal microtubule / Separation of Sister Chromatids / cilium organization / Hedgehog 'off' state / Loss of Nlp from mitotic centrosomes / Recruitment of mitotic centrosome proteins and complexes / Loss of proteins required for interphase microtubule organization from the centrosome / Recruitment of NuMA to mitotic centrosomes / Anchoring of the basal body to the plasma membrane / AURKA Activation by TPX2 / gamma-tubulin ring complex / Regulation of PLK1 Activity at G2/M Transition / flagellated sperm motility / positive regulation of cilium assembly / cell projection organization / MHC class II antigen presentation / UTP biosynthetic process / CTP biosynthetic process / determination of left/right symmetry / protein targeting to membrane / protein targeting to mitochondrion / intermediate filament / extrinsic component of membrane / nucleoside diphosphate kinase activity / GTP biosynthetic process / positive regulation of cell motility / tubulin complex / histone H2AXS140 phosphatase activity / RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity / RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity / RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity / RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity / RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity / MAP kinase serine/threonine phosphatase activity / calmodulin-dependent protein phosphatase activity / myosin phosphatase activity / protein-serine/threonine phosphatase / AMP binding / receptor clustering / ciliary base / beta-tubulin binding
類似検索 - 分子機能
Spermatid-specific manchette-related protein 1 / Testis-expressed sequence 37 protein / Testis-specific serine/threonine-protein kinase 6, catalytic domain / C10orf82-like / : / Spermatid-specific manchette-related protein 1 / TSC21 family / Sperm-associated microtubule inner protein 5 / Protein phosphatase 1 regulatory subunit 32 / Testis, prostate and placenta-expressed protein ...Spermatid-specific manchette-related protein 1 / Testis-expressed sequence 37 protein / Testis-specific serine/threonine-protein kinase 6, catalytic domain / C10orf82-like / : / Spermatid-specific manchette-related protein 1 / TSC21 family / Sperm-associated microtubule inner protein 5 / Protein phosphatase 1 regulatory subunit 32 / Testis, prostate and placenta-expressed protein / Testis-expressed protein 49 / Protein phosphatase 1 regulatory subunit 32 / Sperm microtubule inner protein 8 / Sperm microtubule inner protein 11 / : / Protein of unknown function DUF1143 / Atypical dual specificity phosphatase, subfamily B / Protein of unknown function DUF4513 / : / Cilia- and flagella-associated protein 68 / Sperm-associated microtubule inner protein 10 / Protein of unknown function DUF4541 / Tektin bundle interacting protein 1 / Coiled-coil domain-containing protein 105 / Tektin bundle interacting protein 1 / Cilia and flagella associated protein 90 / DJBP, EF-hand domain / : / EF-hand domain / Sperm-tail PG-rich repeat / FAM183 family / Sperm-tail PG-rich repeat / FAM183A and FAM183B related / Sperm-associated antigen 8 / Cilia- and flagella-associated protein 95 / NDPK7, first NDPk domain / Cilia- and flagella-associated protein 107 / : / Protein CFAP95 / Cilia- and flagella-associated protein 143 / Cilia and flagella associated protein 107 / Tektin / Cilia- and flagella-associated protein 276 / : / Tektin family / Protein of unknown function (DUF3695) / Uncharacterised protein FAM166/UPF0605 / Cilia- and flagella-associated protein 77 / Protein Flattop / Ciliary microtubule inner protein 2B-like / Cilia- and flagella-associated protein 77 / Flattop / Nucleoside diphosphate kinase 7 / Piercer of microtubule wall 1/2 / Piercer of microtubule wall 1/2 / Cilia- and flagella-associated protein 161-like domain / Cilia- and flagella-associated protein 141 / Cilia- and flagella-associated protein 141 / : / : / Meiosis-specific nuclear structural protein 1 / Cilia- and flagella-associated protein 45 / NDPK7, second NDPk domain / Cilia- and flagella- associated protein 210 / CFAP53/TCHP / Trichohyalin-plectin-homology domain / Trichohyalin-plectin-homology domain / RIB43A / RIB43A / DM10 domain / EF-hand domain-containing protein EFHC1/EFHC2/EFHB / DM10 domain / DM10 domain profile. / Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases. / Enkurin domain / : / Calmodulin-binding / Enkurin domain profile. / : / CFA20 domain / Cilia- and flagella-associated protein 20/CFAP20DC / CFA20 domain / Parkin co-regulated protein / Parkin co-regulated protein / Dual specificity phosphatase, catalytic domain / Dual specificity phosphatase, catalytic domain / EF hand / Dual specificity phosphatase, catalytic domain / Nucleoside diphosphate kinase (NDPK)-like domain profile. / Dual specificity protein phosphatase domain profile. / Dual specificity protein phosphatase domain / Nucleoside diphosphate kinase / Nucleoside diphosphate kinase-like domain / Nucleoside diphosphate kinase / NDK / Nucleoside diphosphate kinase-like domain superfamily / EF-hand domain pair / Mir domain superfamily / Tubulin-beta mRNA autoregulation signal. / Alpha tubulin
類似検索 - ドメイン・相同性
GUANOSINE-5'-DIPHOSPHATE / GUANOSINE-5'-TRIPHOSPHATE / Cilia- and flagella-associated protein 77 / Cilia- and flagella- associated protein 210 / Tektin bundle-interacting protein 1 / Cilia- and flagella-associated protein 144 / Tektin-5 / Tubulin alpha-3 chain / Tubulin beta-4B chain / Stabilizer of axonemal microtubules 4 ...GUANOSINE-5'-DIPHOSPHATE / GUANOSINE-5'-TRIPHOSPHATE / Cilia- and flagella-associated protein 77 / Cilia- and flagella- associated protein 210 / Tektin bundle-interacting protein 1 / Cilia- and flagella-associated protein 144 / Tektin-5 / Tubulin alpha-3 chain / Tubulin beta-4B chain / Stabilizer of axonemal microtubules 4 / Tektin-4 / Sperm microtubule inner protein 6 / Sperm-associated antigen 8 / Cilia- and flagella-associated protein 107 / Piercer of microtubule wall 1 protein / Cilia- and flagella-associated protein 52 / Meiosis-specific nuclear structural protein 1 / Sperm microtubule inner protein 8 / EF-hand calcium-binding domain-containing protein 6 / Protein Flattop / Cilia- and flagella-associated protein 161 / Enkurin / Tektin-3 / Cilia- and flagella-associated protein 20 / Sperm microtubule inner protein 11 / EF-hand domain-containing family member B / Ciliary microtubule associated protein 1A / Tektin-2 / Testis-specific serine/threonine-protein kinase 6 / Cilia- and flagella-associated protein 95 / Sperm-associated microtubule inner protein 5 / RIB43A-like with coiled-coils protein 1 / Cilia- and flagella-associated protein 68 / Cilia- and flagella-associated protein 53 / EF-hand domain-containing family member C2 / Ciliary microtubule inner protein 2A / Tektin-like protein 1 / RIB43A-like with coiled-coils protein 2 / Dual specificity phosphatase 21 / Cilia- and flagella-associated protein 141 / Sperm-associated microtubule inner protein 10 / EF-hand domain-containing protein 1 / Cilia- and flagella-associated protein 45 / Cilia- and flagella-associated protein 276 / Protein SPMIP9 / Tektin-1 / Parkin coregulated gene protein homolog / Cilia- and flagella-associated protein 90 / Ciliary microtubule inner protein 2C / Nucleoside diphosphate kinase homolog 7 / Piercer of microtubule wall 2 protein
類似検索 - 構成要素
生物種Mus musculus (ハツカネズミ)
手法電子顕微鏡法 / 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.5 Å
データ登録者Zhou, L.N. / Gui, M. / Wu, J.P.
資金援助 中国, 1件
組織認可番号国
National Natural Science Foundation of China (NSFC) 中国
引用ジャーナル: Cell / 年: 2023
タイトル: Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility.
著者: Lunni Zhou / Haobin Liu / Siyu Liu / Xiaoyu Yang / Yue Dong / Yun Pan / Zhuang Xiao / Beihong Zheng / Yan Sun / Pengyu Huang / Xixi Zhang / Jin Hu / Rui Sun / Shan Feng / Yi Zhu / Mingxi Liu ...著者: Lunni Zhou / Haobin Liu / Siyu Liu / Xiaoyu Yang / Yue Dong / Yun Pan / Zhuang Xiao / Beihong Zheng / Yan Sun / Pengyu Huang / Xixi Zhang / Jin Hu / Rui Sun / Shan Feng / Yi Zhu / Mingxi Liu / Miao Gui / Jianping Wu /
要旨: Sperm motility is crucial for successful fertilization. Highly decorated doublet microtubules (DMTs) form the sperm tail skeleton, which propels the movement of spermatozoa. Using cryo-electron ...Sperm motility is crucial for successful fertilization. Highly decorated doublet microtubules (DMTs) form the sperm tail skeleton, which propels the movement of spermatozoa. Using cryo-electron microscopy (cryo-EM) and artificial intelligence (AI)-based modeling, we determined the structures of mouse and human sperm DMTs and built an atomic model of the 48-nm repeat of the mouse sperm DMT. Our analysis revealed 47 DMT-associated proteins, including 45 microtubule inner proteins (MIPs). We identified 10 sperm-specific MIPs, including seven classes of Tektin5 in the lumen of the A tubule and FAM166 family members that bind the intra-tubulin interfaces. Interestingly, the human sperm DMT lacks some MIPs compared with the mouse sperm DMT. We also discovered variants in 10 distinct MIPs associated with a subtype of asthenozoospermia characterized by impaired sperm motility without evident morphological abnormalities. Our study highlights the conservation and tissue/species specificity of DMTs and expands the genetic spectrum of male infertility.
履歴
登録2023年4月5日登録サイト: PDBJ / 処理サイト: PDBJ
改定 1.02023年7月5日Provider: repository / タイプ: Initial release
改定 1.12024年7月3日Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond / em_admin / Item: _em_admin.last_update

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構造の表示

構造ビューア分子:
MolmilJmol/JSmol

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集合体

登録構造単位
0: Cilia- and flagella-associated protein 95
1: EF-hand domain-containing family member B
2: EF-hand domain-containing family member B
3: Cilia- and flagella-associated protein 53
4: Cilia- and flagella-associated protein 53
5: Nucleoside diphosphate kinase 7
6: Nucleoside diphosphate kinase 7
7: Cilia- and flagella-associated protein 95
8: Cilia- and flagella-associated protein 107
A: Cilia- and flagella-associated protein 141
A0: Tektin-1
A1: Tektin-1
A2: Tektin-1
A3: Tektin-1
A4: Tektin-1
A5: Tektin-1
AA: Tubulin alpha-3 chain
AB: Tubulin beta-4B chain
AC: Tubulin alpha-3 chain
AD: Tubulin beta-4B chain
AE: Tubulin alpha-3 chain
AF: Tubulin beta-4B chain
AG: Tubulin alpha-3 chain
AH: Tubulin beta-4B chain
AI: Tubulin alpha-3 chain
AJ: Tubulin beta-4B chain
AK: Tubulin alpha-3 chain
AL: Tubulin beta-4B chain
AM: Tubulin alpha-3 chain
AN: Tubulin beta-4B chain
AO: Tubulin alpha-3 chain
AP: Tubulin beta-4B chain
B: Meiosis-specific nuclear structural protein 1
B0: Tektin-2
B1: Tektin-2
B2: Tektin-2
B3: Tektin-2
B4: Tektin-2
B5: Tektin-2
BB: Tubulin beta-4B chain
BC: Tubulin alpha-3 chain
BD: Tubulin beta-4B chain
BE: Tubulin alpha-3 chain
BF: Tubulin beta-4B chain
BG: Tubulin alpha-3 chain
BH: Tubulin beta-4B chain
BI: Tubulin alpha-3 chain
BJ: Tubulin beta-4B chain
BK: Tubulin alpha-3 chain
BL: Tubulin beta-4B chain
BM: Tubulin alpha-3 chain
BN: Tubulin beta-4B chain
BO: Tubulin alpha-3 chain
BP: Tubulin beta-4B chain
C: Meiosis-specific nuclear structural protein 1
C0: Tektin-3
C1: Tektin-3
C2: Tektin-3
C3: Tektin-3
C4: Tektin-3
C5: Tektin-3
C6: Tektin-3
CB: Tubulin beta-4B chain
CC: Tubulin alpha-3 chain
CD: Tubulin beta-4B chain
CE: Tubulin alpha-3 chain
CF: Tubulin beta-4B chain
CG: Tubulin alpha-3 chain
CH: Tubulin beta-4B chain
CI: Tubulin alpha-3 chain
CJ: Tubulin beta-4B chain
CK: Tubulin alpha-3 chain
CL: Tubulin beta-4B chain
CM: Tubulin alpha-3 chain
CN: Tubulin beta-4B chain
CO: Tubulin alpha-3 chain
CP: Tubulin beta-4B chain
CQ: Tubulin alpha-3 chain
D: Sperm-associated antigen 8
D0: Tektin-4
D1: Tektin-4
D2: Tektin-4
D3: Tektin-4
D4: Tektin-4
D5: Tektin-4
DB: Tubulin beta-4B chain
DC: Tubulin alpha-3 chain
DD: Tubulin beta-4B chain
DE: Tubulin alpha-3 chain
DF: Tubulin beta-4B chain
DG: Tubulin alpha-3 chain
DH: Tubulin beta-4B chain
DI: Tubulin alpha-3 chain
DJ: Tubulin beta-4B chain
DK: Tubulin alpha-3 chain
DL: Tubulin beta-4B chain
DM: Tubulin alpha-3 chain
DN: Tubulin beta-4B chain
DO: Tubulin alpha-3 chain
DP: Tubulin beta-4B chain
DQ: Tubulin alpha-3 chain
E: Cilia- and flagella-associated protein 161
EA: Tubulin alpha-3 chain
EB: Tubulin beta-4B chain
EC: Tubulin alpha-3 chain
ED: Tubulin beta-4B chain
EE: Tubulin alpha-3 chain
EF: Tubulin beta-4B chain
EG: Tubulin alpha-3 chain
EH: Tubulin beta-4B chain
EI: Tubulin alpha-3 chain
EJ: Tubulin beta-4B chain
EK: Tubulin alpha-3 chain
EL: Tubulin beta-4B chain
EM: Tubulin alpha-3 chain
EN: Tubulin beta-4B chain
EO: Tubulin alpha-3 chain
F: Cilia- and flagella-associated protein 161
FA: Tubulin alpha-3 chain
FB: Tubulin beta-4B chain
FC: Tubulin alpha-3 chain
FD: Tubulin beta-4B chain
FE: Tubulin alpha-3 chain
FF: Tubulin beta-4B chain
FG: Tubulin alpha-3 chain
FH: Tubulin beta-4B chain
FI: Tubulin alpha-3 chain
FJ: Tubulin beta-4B chain
FK: Tubulin alpha-3 chain
FL: Tubulin beta-4B chain
FM: Tubulin alpha-3 chain
FN: Tubulin beta-4B chain
FO: Tubulin alpha-3 chain
G: Piercer of microtubule wall 2 protein
GA: Tubulin alpha-3 chain
GB: Tubulin beta-4B chain
GC: Tubulin alpha-3 chain
GD: Tubulin beta-4B chain
GE: Tubulin alpha-3 chain
GF: Tubulin beta-4B chain
GG: Tubulin alpha-3 chain
GH: Tubulin beta-4B chain
GI: Tubulin alpha-3 chain
GJ: Tubulin beta-4B chain
GK: Tubulin alpha-3 chain
GL: Tubulin beta-4B chain
GM: Tubulin alpha-3 chain
GN: Tubulin beta-4B chain
GO: Tubulin alpha-3 chain
H: Protein FAM166A
HA: Tubulin alpha-3 chain
HB: Tubulin beta-4B chain
HC: Tubulin alpha-3 chain
HD: Tubulin beta-4B chain
HE: Tubulin alpha-3 chain
HF: Tubulin beta-4B chain
HG: Tubulin alpha-3 chain
HH: Tubulin beta-4B chain
HI: Tubulin alpha-3 chain
HJ: Tubulin beta-4B chain
HK: Tubulin alpha-3 chain
HL: Tubulin beta-4B chain
HM: Tubulin alpha-3 chain
HN: Tubulin beta-4B chain
HO: Tubulin alpha-3 chain
HP: Tubulin beta-4B chain
I: Protein FAM166A
I1: Cilia- and flagella-associated protein 68
IA: Tubulin alpha-3 chain
IB: Tubulin beta-4B chain
IC: Tubulin alpha-3 chain
ID: Tubulin beta-4B chain
IE: Tubulin alpha-3 chain
IF: Tubulin beta-4B chain
IG: Tubulin alpha-3 chain
IH: Tubulin beta-4B chain
II: Tubulin alpha-3 chain
IJ: Tubulin beta-4B chain
IK: Tubulin alpha-3 chain
IL: Tubulin beta-4B chain
IM: Tubulin alpha-3 chain
IN: Tubulin beta-4B chain
IO: Tubulin alpha-3 chain
IP: Tubulin beta-4B chain
J: Protein FAM166A
J1: Cilia and flagella-associated protein 77
J2: Cilia and flagella-associated protein 77
J3: Cilia and flagella-associated protein 77
J4: Cilia and flagella-associated protein 77
J5: Cilia and flagella-associated protein 77
JB: Tubulin beta-4B chain
JC: Tubulin alpha-3 chain
JD: Tubulin beta-4B chain
JE: Tubulin alpha-3 chain
JF: Tubulin beta-4B chain
JG: Tubulin alpha-3 chain
JH: Tubulin beta-4B chain
JI: Tubulin alpha-3 chain
JJ: Tubulin beta-4B chain
JK: Tubulin alpha-3 chain
JL: Tubulin beta-4B chain
JM: Tubulin alpha-3 chain
JN: Tubulin beta-4B chain
JO: Tubulin alpha-3 chain
JP: Tubulin beta-4B chain
JQ: Tubulin alpha-3 chain
K: Protein FAM166A
K1: Family with sequence similarity 183, member B
K2: Family with sequence similarity 183, member B
K3: Sperm-associated antigen 8
KA: Tubulin alpha-3 chain
KB: Tubulin beta-4B chain
KC: Tubulin alpha-3 chain
KD: Tubulin beta-4B chain
KE: Tubulin alpha-3 chain
KF: Tubulin beta-4B chain
KG: Tubulin alpha-3 chain
KH: Tubulin beta-4B chain
KI: Tubulin alpha-3 chain
KJ: Tubulin beta-4B chain
KK: Tubulin alpha-3 chain
KL: Tubulin beta-4B chain
KM: Tubulin alpha-3 chain
KN: Tubulin beta-4B chain
KO: Tubulin alpha-3 chain
KP: Tubulin beta-4B chain
L: Protein FAM166A
L1: Cilia- and flagella-associated protein 90
LA: Tubulin alpha-3 chain
LB: Tubulin beta-4B chain
LC: Tubulin alpha-3 chain
LD: Tubulin beta-4B chain
LE: Tubulin alpha-3 chain
LF: Tubulin beta-4B chain
LG: Tubulin alpha-3 chain
LH: Tubulin beta-4B chain
LI: Tubulin alpha-3 chain
LJ: Tubulin beta-4B chain
LK: Tubulin alpha-3 chain
LL: Tubulin beta-4B chain
LM: Tubulin alpha-3 chain
LN: Tubulin beta-4B chain
LO: Tubulin alpha-3 chain
LP: Tubulin beta-4B chain
M: Protein FAM166A
M1: Protein FAM166C
M2: Protein FAM166C
M3: Protein FAM166C
M4: Protein FAM166C
MA: Tubulin alpha-3 chain
MB: Tubulin beta-4B chain
MC: Tubulin alpha-3 chain
MD: Tubulin beta-4B chain
ME: Tubulin alpha-3 chain
MF: Tubulin beta-4B chain
MG: Tubulin alpha-3 chain
MH: Tubulin beta-4B chain
MI: Tubulin alpha-3 chain
MJ: Tubulin beta-4B chain
MK: Tubulin alpha-3 chain
ML: Tubulin beta-4B chain
MM: Tubulin alpha-3 chain
MN: Tubulin beta-4B chain
MO: Tubulin alpha-3 chain
MP: Tubulin beta-4B chain
N: Protein FAM166A
N1: Cilia- and flagella-associated protein 141
N2: Cilia- and flagella-associated protein 161
NA: Tubulin alpha-3 chain
NB: Tubulin beta-4B chain
NC: Tubulin alpha-3 chain
ND: Tubulin beta-4B chain
NE: Tubulin alpha-3 chain
NF: Tubulin beta-4B chain
NG: Tubulin alpha-3 chain
NH: Tubulin beta-4B chain
NI: Tubulin alpha-3 chain
NJ: Tubulin beta-4B chain
NK: Tubulin alpha-3 chain
NL: Tubulin beta-4B chain
NM: Tubulin alpha-3 chain
NN: Tubulin beta-4B chain
NO: Tubulin alpha-3 chain
NP: Tubulin beta-4B chain
O: RIB43A-like with coiled-coils protein 1
O1: Dual specificity phosphatase 21
O2: Dual specificity phosphatase 21
O3: Dual specificity phosphatase 21
O4: Dual specificity phosphatase 21
O5: EF-hand domain-containing protein 1
O6: EF-hand domain-containing protein 1
O7: Protein FAM166A
O8: Protein FAM166A
O9: Protein FAM166A
OA: Tubulin alpha-3 chain
OB: Tubulin beta-4B chain
OC: Tubulin alpha-3 chain
OD: Tubulin beta-4B chain
OE: Tubulin alpha-3 chain
OF: Tubulin beta-4B chain
OG: Tubulin alpha-3 chain
OH: Tubulin beta-4B chain
OI: Tubulin alpha-3 chain
OJ: Tubulin beta-4B chain
OK: Tubulin alpha-3 chain
OL: Tubulin beta-4B chain
OM: Tubulin alpha-3 chain
ON: Tubulin beta-4B chain
OO: Tubulin alpha-3 chain
OP: Tubulin beta-4B chain
P: RIB43A-like with coiled-coils protein 1
P1: Testis expressed 49
P2: Testis expressed 49
P3: Testis-expressed sequence 37 protein
P4: Testis-expressed sequence 37 protein
P5: Testis-expressed sequence 37 protein
P6: Testis-expressed sequence 37 protein
P7: Testis-expressed sequence 37 protein
P8: Protein FAM166A
P9: Protein FAM166A
PB: Tubulin beta-4B chain
PC: Tubulin alpha-3 chain
PD: Tubulin beta-4B chain
PE: Tubulin alpha-3 chain
PF: Tubulin beta-4B chain
PG: Tubulin alpha-3 chain
PH: Tubulin beta-4B chain
PI: Tubulin alpha-3 chain
PJ: Tubulin beta-4B chain
PK: Tubulin alpha-3 chain
PL: Tubulin beta-4B chain
PM: Tubulin alpha-3 chain
PN: Tubulin beta-4B chain
PO: Tubulin alpha-3 chain
PP: Tubulin beta-4B chain
Q: RIB43A-like with coiled-coils protein 1
Q1: Tektin bundle-interacting protein 1
Q2: Tektin bundle-interacting protein 1
Q3: Tektin bundle-interacting protein 1
Q4: Tektin bundle-interacting protein 1
Q5: Tektin bundle-interacting protein 1
QB: Tubulin beta-4B chain
QC: Tubulin alpha-3 chain
QD: Tubulin beta-4B chain
QE: Tubulin alpha-3 chain
QF: Tubulin beta-4B chain
QG: Tubulin alpha-3 chain
QH: Tubulin beta-4B chain
QI: Tubulin alpha-3 chain
QJ: Tubulin beta-4B chain
QK: Tubulin alpha-3 chain
QL: Tubulin beta-4B chain
QM: Tubulin alpha-3 chain
QN: Tubulin beta-4B chain
QO: Tubulin alpha-3 chain
QP: Tubulin beta-4B chain
R: RIB43A-like with coiled-coils protein 2
R0: Tektin-2
R1: Tektin-2
R2: Tektin-2
R3: Tektin-2
R4: Tektin-2
R5: Tektin-2
RC: Tubulin alpha-3 chain
RD: Tubulin beta-4B chain
RE: Tubulin alpha-3 chain
RF: Tubulin beta-4B chain
RG: Tubulin alpha-3 chain
RH: Tubulin beta-4B chain
RI: Tubulin alpha-3 chain
RJ: Tubulin beta-4B chain
RK: Tubulin alpha-3 chain
RL: Tubulin beta-4B chain
RM: Tubulin alpha-3 chain
RN: Tubulin beta-4B chain
RO: Tubulin alpha-3 chain
RP: Tubulin beta-4B chain
S: RIB43A-like with coiled-coils protein 2
S0: Tektin-3
S1: Tektin-3
S2: Tektin-3
S3: Tektin-3
S4: Tektin-3
S5: Tektin-3
S6: Tektin-3
S7: Tektin-3
S8: Tektin-3
S9: Tektin-3
SA: Tubulin alpha-3 chain
SB: Tubulin beta-4B chain
SC: Tubulin alpha-3 chain
SD: Tubulin beta-4B chain
SE: Tubulin alpha-3 chain
SF: Tubulin beta-4B chain
SG: Tubulin alpha-3 chain
SH: Tubulin beta-4B chain
SI: Tubulin alpha-3 chain
SJ: Tubulin beta-4B chain
SK: Tubulin alpha-3 chain
SL: Tubulin beta-4B chain
SM: Tubulin alpha-3 chain
SN: Tubulin beta-4B chain
T: EF-hand domain-containing protein 1
T0: Tektin-4
T1: Tektin-4
T2: Tektin-4
T3: Tektin-4
T4: Tektin-4
T5: Tektin-4
TA: Tubulin alpha-3 chain
TB: Tubulin beta-4B chain
TC: Tubulin alpha-3 chain
TD: Tubulin beta-4B chain
TE: Tubulin alpha-3 chain
TF: Tubulin beta-4B chain
TG: Tubulin alpha-3 chain
TH: Tubulin beta-4B chain
TI: Tubulin alpha-3 chain
TJ: Tubulin beta-4B chain
TK: Tubulin alpha-3 chain
TL: Tubulin beta-4B chain
TM: Tubulin alpha-3 chain
TN: Tubulin beta-4B chain
U: EF-hand domain-containing protein 1
U0: Tektin-5
U1: Tektin-5
U2: Tektin-5
U3: Tektin-5
U4: Tektin-5
U5: Tektin-5
U6: Tektin-5
U7: Tektin-5
U8: Tektin-5
U9: Tektin-5
UA: Tubulin alpha-3 chain
UB: Tubulin beta-4B chain
UC: Tubulin alpha-3 chain
UD: Tubulin beta-4B chain
UE: Tubulin alpha-3 chain
UF: Tubulin beta-4B chain
UG: Tubulin alpha-3 chain
UH: Tubulin beta-4B chain
UI: Tubulin alpha-3 chain
UJ: Tubulin beta-4B chain
UK: Tubulin alpha-3 chain
UL: Tubulin beta-4B chain
UM: Tubulin alpha-3 chain
UN: Tubulin beta-4B chain
UO: Tubulin alpha-3 chain
V: EF-hand domain-containing protein 1
V0: Tektin-5
V1: Tektin-5
V2: Tektin-5
V3: Tektin-5
V4: Tektin-5
V5: Tektin-5
V6: Tektin-5
V7: Tektin-5
V8: Tektin-5
V9: Tektin-5
VA: Tubulin alpha-3 chain
VB: Tubulin beta-4B chain
VC: Tubulin alpha-3 chain
VD: Tubulin beta-4B chain
VE: Tubulin alpha-3 chain
VF: Tubulin beta-4B chain
VG: Tubulin alpha-3 chain
VH: Tubulin beta-4B chain
VI: Tubulin alpha-3 chain
VJ: Tubulin beta-4B chain
VK: Tubulin alpha-3 chain
VL: Tubulin beta-4B chain
VM: Tubulin alpha-3 chain
VN: Tubulin beta-4B chain
VO: Tubulin alpha-3 chain
W: EF-hand domain-containing family member C2
W0: Tektin-5
W2: Tektin-5
W4: Tektin-5
W5: Tektin-5
W6: Tektin-5
W7: Tektin-5
WA: Tubulin alpha-3 chain
WB: Tubulin beta-4B chain
WC: Tubulin alpha-3 chain
WD: Tubulin beta-4B chain
WE: Tubulin alpha-3 chain
WF: Tubulin beta-4B chain
WG: Tubulin alpha-3 chain
WH: Tubulin beta-4B chain
WI: Tubulin alpha-3 chain
WJ: Tubulin beta-4B chain
WK: Tubulin alpha-3 chain
WL: Tubulin beta-4B chain
WM: Tubulin alpha-3 chain
WN: Tubulin beta-4B chain
WO: Tubulin alpha-3 chain
WP: Tubulin beta-4B chain
X: EF-hand domain-containing family member C2
X0: Spermatid-specific manchette-related protein 1
X1: Spermatid-specific manchette-related protein 1
X2: Spermatid-specific manchette-related protein 1
X3: Spermatid-specific manchette-related protein 1
X4: Protein phosphatase 1 regulatory subunit 32
X5: Protein phosphatase 1 regulatory subunit 32
X6: Testis-specific serine/threonine-protein kinase 6
X7: Testis-specific serine/threonine-protein kinase 6
X8: Testis-specific serine/threonine-protein kinase 6
XA: Cilia- and flagella-associated protein 20
XB: Cilia- and flagella-associated protein 20
XC: Cilia- and flagella-associated protein 20
XD: Cilia- and flagella-associated protein 20
XE: Cilia- and flagella-associated protein 20
XF: Cilia- and flagella-associated protein 20
XG: Cilia- and flagella-associated protein 20
XH: Cilia- and flagella-associated protein 20
Y: EF-hand domain-containing family member C2
Y0: Outer dense fiber protein 3
Y1: Outer dense fiber protein 3
Y2: Outer dense fiber protein 3
Y3: Outer dense fiber protein 3
Y4: Outer dense fiber protein 3
Y5: Outer dense fiber protein 3
YA: Parkin coregulated gene protein homolog
YB: Parkin coregulated gene protein homolog
YC: Parkin coregulated gene protein homolog
YD: Parkin coregulated gene protein homolog
YE: Parkin coregulated gene protein homolog
YF: Parkin coregulated gene protein homolog
YG: Parkin coregulated gene protein homolog
YH: Parkin coregulated gene protein homolog
Z: EF-hand domain-containing family member C2
Z1: Testis, prostate and placenta-expressed protein
Z2: Protein FAM166A
Z3: Protein FAM166A
Z4: Protein FAM166A
Z5: Protein FAM166A
a: Cilia- and flagella-associated protein 45
a1: Uncharacterized protein C10orf82 homolog
a2: Uncharacterized protein C10orf82 homolog
a3: Uncharacterized protein C10orf82 homolog
a4: Uncharacterized protein C10orf82 homolog
a6: Cilia- and flagella-associated protein 45
b: Cilia- and flagella-associated protein 45
b1: Coiled-coil domain-containing protein 105
b2: Coiled-coil domain-containing protein 105
b3: Coiled-coil domain-containing protein 105
b4: Coiled-coil domain-containing protein 105
b5: Coiled-coil domain-containing protein 105
c: Cilia- and flagella-associated protein 45
d: Cilia- and flagella-associated protein 45
e: Cilia- and flagella-associated protein 52
f: Cilia- and flagella-associated protein 52
g: Cilia- and flagella-associated protein 52
h: Enkurin
h1: Testis-expressed protein 43
h2: Testis-expressed protein 43
h3: Testis-expressed protein 43
h4: Testis-expressed protein 43
i: Enkurin
i1: Protein Flattop
i2: EF-hand calcium-binding domain-containing protein 6
i3: EF-hand calcium-binding domain-containing protein 6
i4: EF-hand calcium-binding domain-containing protein 6
j: Enkurin
j1: Nucleoside diphosphate kinase 7
k: Enkurin
l: Protein Flattop
m: Protein Flattop
n: Protein Flattop
o: Cilia- and flagella-associated protein 210
p: Cilia- and flagella-associated protein 210
q: Cilia- and flagella-associated protein 276
r: Cilia- and flagella-associated protein 276
s: Cilia- and flagella-associated protein 276
y: Piercer of microtubule wall 1 protein
ヘテロ分子


分子量 (理論値)分子数
合計 (水以外)27,904,7421108
ポリマ－27,729,286576
非ポリマー175,456532
水00
1


  • 登録構造と同一
  • 登録者が定義した集合体
  • 根拠: 電子顕微鏡法
タイプ名称対称操作数
identity operation1_5551

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要素

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Cilia- and flagella-associated protein ... , 12種, 33分子 07348AN1EFN2I1L1XAXBXCXDXEXFXGXHaa6bcdefgop...

#1: タンパク質 Cilia- and flagella-associated protein 95


分子量: 26633.035 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9CQC3
#3: タンパク質 Cilia- and flagella-associated protein 53 / Coiled-coil domain-containing protein 11


分子量: 62036.609 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9D439
#5: タンパク質 Cilia- and flagella-associated protein 107


分子量: 23062.510 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q4KKZ1
#6: タンパク質 Cilia- and flagella-associated protein 141


分子量: 12278.145 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9D9D9
#15: タンパク質 Cilia- and flagella-associated protein 161


分子量: 34433.383 Da / 分子数: 3 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q6P8Y0
#18: タンパク質 Cilia- and flagella-associated protein 68


分子量: 19552.668 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9D131
#21: タンパク質 Cilia- and flagella-associated protein 90 / Y regulated sperm protein


分子量: 20886.428 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9DAR0
#35: タンパク質
Cilia- and flagella-associated protein 20 / Gene trap locus 3 protein


分子量: 22781.389 Da / 分子数: 8 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q8BTU1
#39: タンパク質
Cilia- and flagella-associated protein 45 / Coiled-coil domain-containing protein 19 / Nasopharyngeal epithelium-specific protein 1


分子量: 65962.016 Da / 分子数: 5 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9D9U9
#42: タンパク質 Cilia- and flagella-associated protein 52 / WD repeat-containing protein 16


分子量: 68322.164 Da / 分子数: 3 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q5F201
#47: タンパク質 Cilia- and flagella-associated protein 210 / Coiled-coil domain-containing protein 173


分子量: 65266.520 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: A0JLY1
#48: タンパク質 Cilia- and flagella-associated protein 276


分子量: 18960.092 Da / 分子数: 3 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9DAD0

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EF-hand domain-containing family member ... , 2種, 6分子 12WXYZ

#2: タンパク質 EF-hand domain-containing family member B / Cilia- and flagella-associated protein 21


分子量: 95891.961 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q8CDU5
#31: タンパク質
EF-hand domain-containing family member C2


分子量: 87758.023 Da / 分子数: 4 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9D485

+
タンパク質 , 29種, 521分子 56j1A0A1A2A3A4A5AAACAEAGAIAKAMAOBCBEBGBIBKBMBOCCCECGCICKCM...

#4: タンパク質 Nucleoside diphosphate kinase 7 / NDK 7 / NDP kinase 7 / nm23-M7


分子量: 44489.828 Da / 分子数: 3 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9QXL8, nucleoside-diphosphate kinase
#7: タンパク質
Tektin-1


分子量: 48713.035 Da / 分子数: 6 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9DAJ2
#8: タンパク質 ...
Tubulin alpha-3 chain / Alpha-tubulin 3/7 / Alpha-tubulin isotype M-alpha-3/7 / Tubulin alpha-3/alpha-7 chain


分子量: 50012.359 Da / 分子数: 178 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ)
参照: UniProt: P05214, 加水分解酵素; 酸無水物に作用; GTPに作用・細胞または細胞小器官の運動に関与
#9: タンパク質 ...
Tubulin beta-4B chain / Tubulin beta-2C chain


分子量: 49877.824 Da / 分子数: 176 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: P68372
#10: タンパク質 Meiosis-specific nuclear structural protein 1


分子量: 60353.012 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q61884
#11: タンパク質
Tektin-2 / Tektin-t / Testicular tektin


分子量: 50385.066 Da / 分子数: 12 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q922G7
#12: タンパク質
Tektin-3


分子量: 56754.777 Da / 分子数: 17 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q6X6Z7
#13: タンパク質 Sperm-associated antigen 8 / Sperm membrane protein 1 / SMP-1 / Sperm membrane protein BS-84


分子量: 50591.805 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q3V0Q6
#14: タンパク質
Tektin-4 / Testicular microtubules-related protein 4


分子量: 52121.449 Da / 分子数: 12 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q149S1
#17: タンパク質
Protein FAM166A


分子量: 36659.566 Da / 分子数: 16 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9D4K5
#19: タンパク質
Cilia and flagella-associated protein 77


分子量: 32786.020 Da / 分子数: 5 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: A0A087WRI3
#20: タンパク質 Family with sequence similarity 183, member B / Testis highly expressed protein 6


分子量: 16357.517 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: D2D553
#22: タンパク質
Protein FAM166C


分子量: 23097.957 Da / 分子数: 4 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9DAS2
#24: タンパク質
Dual specificity phosphatase 21


分子量: 21527.574 Da / 分子数: 4 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ)
参照: UniProt: Q9D9D8, protein-serine/threonine phosphatase, protein-tyrosine-phosphatase
#25: タンパク質
EF-hand domain-containing protein 1 / Myoclonin-1


分子量: 75235.422 Da / 分子数: 5 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9D9T8
#26: タンパク質 Testis expressed 49


分子量: 15528.622 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q8CDT5
#28: タンパク質
Tektin bundle-interacting protein 1


分子量: 23987.262 Da / 分子数: 5 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: A6H6Q4
#30: タンパク質 ...
Tektin-5


分子量: 62817.535 Da / 分子数: 26 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: G5E8A8
#32: タンパク質
Spermatid-specific manchette-related protein 1 / Ciliated bronchial epithelial protein 1


分子量: 29977.191 Da / 分子数: 4 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q2MH31
#33: タンパク質 Protein phosphatase 1 regulatory subunit 32 / Protein IIIG9


分子量: 47873.078 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q148A4
#34: タンパク質 Testis-specific serine/threonine-protein kinase 6 / TSK-6 / TSSK-6 / Testis-specific kinase 6 / Serine/threonine-protein kinase SSTK / Small ...TSK-6 / TSSK-6 / Testis-specific kinase 6 / Serine/threonine-protein kinase SSTK / Small serine/threonine kinase


分子量: 30332.943 Da / 分子数: 3 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ)
参照: UniProt: Q925K9, non-specific serine/threonine protein kinase
#36: タンパク質
Outer dense fiber protein 3 / Outer dense fiber of sperm tails protein 3 / Sperm tail protein SHIPPO 1


分子量: 27690.973 Da / 分子数: 6 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q920N1
#37: タンパク質
Parkin coregulated gene protein homolog / Hypertension-related protein 1-like protein / PARK2 coregulated gene protein


分子量: 27763.268 Da / 分子数: 8 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9DAK2
#38: タンパク質 Testis, prostate and placenta-expressed protein


分子量: 24985.697 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q6IMH0
#40: タンパク質
Uncharacterized protein C10orf82 homolog


分子量: 25847.469 Da / 分子数: 4 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9CQT6
#41: タンパク質
Coiled-coil domain-containing protein 105


分子量: 57406.484 Da / 分子数: 5 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9D4K7
#43: タンパク質
Enkurin


分子量: 29587.521 Da / 分子数: 4 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q6SP97
#45: タンパク質
Protein Flattop / Cilia- and flagella-associated protein 126


分子量: 20575.123 Da / 分子数: 4 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q6P8X9
#46: タンパク質 EF-hand calcium-binding domain-containing protein 6 / DJ-1-binding protein / DJBP


分子量: 176028.312 Da / 分子数: 3 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q6P1E8

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Piercer of microtubule wall ... , 2種, 2分子 Gy

#16: タンパク質 Piercer of microtubule wall 2 protein


分子量: 13728.513 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: V9GXK1
#49: タンパク質 Piercer of microtubule wall 1 protein / Pierce1 / p53-induced expression in RB-null cells protein 1


分子量: 18862.852 Da / 分子数: 1 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q5BN45

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RIB43A-like with coiled-coils protein ... , 2種, 5分子 OPQRS

#23: タンパク質 RIB43A-like with coiled-coils protein 1


分子量: 45032.160 Da / 分子数: 3 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9D0B8
#29: タンパク質 RIB43A-like with coiled-coils protein 2


分子量: 45328.156 Da / 分子数: 2 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9D4Q1

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Testis-expressed ... , 2種, 9分子 P3P4P5P6P7h1h2h3h4

#27: タンパク質
Testis-expressed sequence 37 protein


分子量: 21069.139 Da / 分子数: 5 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9DAG4
#44: タンパク質
Testis-expressed protein 43


分子量: 16305.608 Da / 分子数: 4 / 由来タイプ: 天然 / 由来: (天然) Mus musculus (ハツカネズミ) / 参照: UniProt: Q9D9I1

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非ポリマー , 3種, 532分子

#50: 化合物...
ChemComp-GTP / GUANOSINE-5'-TRIPHOSPHATE / GTP


分子量: 523.180 Da / 分子数: 178 / 由来タイプ: 合成 / 式: C10H16N5O14P3 / コメント: GTP, エネルギー貯蔵分子*YM
#51: 化合物...
ChemComp-MG / MAGNESIUM ION / マグネシウムジカチオン


分子量: 24.305 Da / 分子数: 178 / 由来タイプ: 合成 / 式: Mg
#52: 化合物...
ChemComp-GDP / GUANOSINE-5'-DIPHOSPHATE / GDP


タイプ: RNA linking / 分子量: 443.201 Da / 分子数: 176 / 由来タイプ: 合成 / 式: C10H15N5O11P2 / コメント: GDP, エネルギー貯蔵分子*YM

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詳細

研究の焦点であるリガンドがあるかN

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実験情報

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実験

実験手法: 電子顕微鏡法
EM実験試料の集合状態: FILAMENT / ３次元再構成法: 単粒子再構成法

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試料調製

構成要素名称: Mouse sperm DMT / タイプ: COMPLEX / Entity ID: #1-#49 / 由来: NATURAL
分子量実験値: NO
由来(天然)生物種: Mus musculus (ハツカネズミ)
緩衝液pH: 7.5
試料包埋: NO / シャドウイング: NO / 染色: NO / 凍結: YES
急速凍結装置: FEI VITROBOT MARK IV / 凍結剤: ETHANE

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電子顕微鏡撮影

実験機器
モデル: Titan Krios / 画像提供: FEI Company
顕微鏡モデル: FEI TITAN KRIOS
電子銃電子線源: FIELD EMISSION GUN / 加速電圧: 300 kV / 照射モード: FLOOD BEAM
電子レンズモード: BRIGHT FIELD / 倍率（公称値）: 81000 X / 最大 デフォーカス（公称値）: 2600 nm / 最小 デフォーカス（公称値）: 1500 nm
試料ホルダ試料ホルダーモデル: FEI TITAN KRIOS AUTOGRID HOLDER
撮影平均露光時間: 2.56 sec. / 電子線照射量: 50 e/Å2 / フィルム・検出器のモデル: GATAN K3 (6k x 4k) / 実像数: 25135

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解析

ソフトウェア名称: PHENIX / バージョン: 1.20.1_4487: phenix.real_space_refine / 分類: 精密化
CTF補正タイプ: PHASE FLIPPING AND AMPLITUDE CORRECTION
3次元再構成解像度: 3.5 Å / 解像度の算出法: FSC 0.143 CUT-OFF / 粒子像の数: 95290 / 対称性のタイプ: POINT

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万見について

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お知らせ

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2022年2月9日: EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

EMDBエントリの付随情報ファイルのフォーマットが新しくなりました

  • EMDBのヘッダファイルのバージョン3が、公式のフォーマットとなりました。
  • これまでは公式だったバージョン1.9は、アーカイブから削除されます。

関連情報:EMDBヘッダ

外部リンク:wwPDBはEMDBデータモデルのバージョン3へ移行します

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2020年8月12日: 新型コロナ情報

新型コロナ情報

URL: https://pdbj.org/emnavi/covid19.php

新ページ: EM Navigatorに新型コロナウイルスの特設ページを開設しました。

関連情報:Covid-19情報 / 2020年3月5日: 新型コロナウイルスの構造データ

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2020年3月5日: 新型コロナウイルスの構造データ

新型コロナウイルスの構造データ

関連情報:万見生物種 / 2020年8月12日: 新型コロナ情報

外部リンク:COVID-19特集ページ - PDBj / 今月の分子2020年2月：コロナウイルスプロテーアーゼ

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2019年1月31日: EMDBのIDの桁数の変更

EMDBのIDの桁数の変更

  • EMDBエントリに付与されているアクセスコード(EMDB-ID)は4桁の数字(例、EMD-1234)でしたが、間もなく枯渇します。これまでの4桁のID番号は4桁のまま変更されませんが、4桁の数字を使い切った後に発行されるIDは5桁以上の数字(例、EMD-12345)になります。5桁のIDは2019年の春頃から発行される見通しです。
  • EM Navigator/万見では、接頭語「EMD-」は省略されています。

関連情報:Q: 「EMD」とは何ですか？ / 万見/EM NavigatorにおけるID/アクセスコードの表記

外部リンク:EMDB Accession Codes are Changing Soon! / PDBjへお問い合わせ

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2017年7月12日: PDB大規模アップデート

PDB大規模アップデート

  • 新バージョンのPDBx/mmCIF辞書形式に基づくデータがリリースされました。
  • 今回の更新はバージョン番号が4から5になる大規模なもので、全エントリデータの書き換えが行われる「Remediation」というアップデートに該当します。
  • このバージョンアップで、電子顕微鏡の実験手法に関する多くの項目の書式が改定されました(例：em_softwareなど)。
  • EM NavigatorとYorodumiでも、この改定に基づいた表示内容になります。

外部リンク:wwPDB Remediation / OneDepデータ基準に準拠した、より強化された内容のモデル構造ファイルが、PDBアーカイブで公開されました。

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万見 (Yorodumi)

幾万の構造データを、幾万の視点から

  • 万見(Yorodumi)は、EMDB/PDB/SASBDBなどの構造データを閲覧するためのページです。
  • EM Navigatorの詳細ページの後継、Omokage検索のフロントエンドも兼ねています。

関連情報:EMDB / PDB / SASBDB / 3つのデータバンクの比較 / 万見検索 / 2016年8月31日: 新しいEM Navigatorと万見 / 万見文献 / Jmol/JSmol / 機能・相同性情報 / 新しいEM Navigatorと万見の変更点

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