- PDB-8iya: Complex of SETDB1-derived peptide bound to UBE2E1 -
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Basic information
Entry
Database: PDB / ID: 8iya
Title
Complex of SETDB1-derived peptide bound to UBE2E1
Components
Histone-lysine N-methyltransferase SETDB1
Ubiquitin-conjugating enzyme E2 E1
Keywords
PROTEIN BINDING / Ubiquitin / Recognition / Conjugation
Function / homology
Function and homology information
ISG15 transferase activity / [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase / histone H3K9 trimethyltransferase activity / histone H3K9 monomethyltransferase activity / ISG15-protein conjugation / positive regulation of DNA methylation-dependent heterochromatin formation / Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase / histone H3K9 methyltransferase activity / histone H3K9me2 methyltransferase activity / Inactivation of APC/C via direct inhibition of the APC/C complex ...ISG15 transferase activity / [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase / histone H3K9 trimethyltransferase activity / histone H3K9 monomethyltransferase activity / ISG15-protein conjugation / positive regulation of DNA methylation-dependent heterochromatin formation / Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase / histone H3K9 methyltransferase activity / histone H3K9me2 methyltransferase activity / Inactivation of APC/C via direct inhibition of the APC/C complex / APC/C:Cdc20 mediated degradation of mitotic proteins / negative regulation of single stranded viral RNA replication via double stranded DNA intermediate / Aberrant regulation of mitotic exit in cancer due to RB1 defects / (E3-independent) E2 ubiquitin-conjugating enzyme / Phosphorylation of the APC/C / E2 ubiquitin-conjugating enzyme / ubiquitin conjugating enzyme activity / Regulation of APC/C activators between G1/S and early anaphase / Transcriptional Regulation by VENTX / protein K48-linked ubiquitination / heterochromatin organization / ubiquitin ligase complex / APC/C:Cdc20 mediated degradation of Cyclin B / APC-Cdc20 mediated degradation of Nek2A / Synthesis of active ubiquitin: roles of E1 and E2 enzymes / Autodegradation of Cdh1 by Cdh1:APC/C / APC/C:Cdc20 mediated degradation of Securin / Assembly of the pre-replicative complex / promoter-specific chromatin binding / Cdc20:Phospho-APC/C mediated degradation of Cyclin A / APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 / CDK-mediated phosphorylation and removal of Cdc6 / PKMTs methylate histone lysines / ISG15 antiviral mechanism / protein polyubiquitination / Separation of Sister Chromatids / ubiquitin-protein transferase activity / Antigen processing: Ubiquitination & Proteasome degradation / E3 ubiquitin ligases ubiquitinate target proteins / chromosome / Senescence-Associated Secretory Phenotype (SASP) / ubiquitin-dependent protein catabolic process / methylation / protein ubiquitination / negative regulation of gene expression / intracellular membrane-bounded organelle / chromatin binding / positive regulation of transcription by RNA polymerase II / DNA binding / zinc ion binding / nucleoplasm / ATP binding / nucleus / cytoplasm / cytosol Similarity search - Function
Histone-lysine N-methyltransferase SETDB1 / Domain of unknown function DUF5604 / : / Domain of unknown function (DUF5604) / Histone-lysine N-methyltransferase (EC 2.1.1.43) family profile. / Histone methyltransferase, Tudor domain 1 / Histone methyltransferase, Tudor domain 2 / Histone methyltransferase Tudor domain / Histone methyltransferase Tudor domain 1 / Pre-SET domain ...Histone-lysine N-methyltransferase SETDB1 / Domain of unknown function DUF5604 / : / Domain of unknown function (DUF5604) / Histone-lysine N-methyltransferase (EC 2.1.1.43) family profile. / Histone methyltransferase, Tudor domain 1 / Histone methyltransferase, Tudor domain 2 / Histone methyltransferase Tudor domain / Histone methyltransferase Tudor domain 1 / Pre-SET domain / Pre-SET motif / Pre-SET domain profile. / N-terminal to some SET domains / Tudor domain / Tudor domain / Post-SET domain / Post-SET domain profile. / Methyl-CpG binding domain / Methyl-CpG DNA binding / Methyl-CpG binding domain / Methyl-CpG-binding domain (MBD) profile. / DNA-binding domain superfamily / Ubiquitin-conjugating enzyme, active site / Ubiquitin-conjugating (UBC) active site signature. / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / Ubiquitin-conjugating enzyme E2, catalytic domain homologues / Ubiquitin-conjugating enzyme E2 / Ubiquitin-conjugating enzyme / Ubiquitin-conjugating (UBC) core domain profile. / SET domain superfamily / SET domain / SET domain profile. / SET domain / Ubiquitin-conjugating enzyme/RWD-like Similarity search - Domain/homology
Mass: 19203.832 Da / Num. of mol.: 3 / Mutation: C67S, C122P, C153S, C159P Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: UBE2E1, UBCH6 / Plasmid: pET28a / Production host: Escherichia coli (E. coli) References: UniProt: P51965, E2 ubiquitin-conjugating enzyme, (E3-independent) E2 ubiquitin-conjugating enzyme
#2: Protein/peptide
Histone-lysineN-methyltransferaseSETDB1 / ERG-associated protein with SET domain / ESET / Histone H3-K9 methyltransferase 4 / H3-K9-HMTase 4 ...ERG-associated protein with SET domain / ESET / Histone H3-K9 methyltransferase 4 / H3-K9-HMTase 4 / Lysine N-methyltransferase 1E / SET domain bifurcated 1
Mass: 686.689 Da / Num. of mol.: 3 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: SETDB1, ESET, KIAA0067, KMT1E / Production host: Escherichia coli (E. coli) References: UniProt: Q15047, [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase
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