+Open data
-Basic information
Entry | Database: PDB / ID: 8ivw | ||||||
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Title | Crystal structure of NRP2 in complex with aNRP2-10 Fab fragment | ||||||
Components |
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Keywords | MEMBRANE PROTEIN / Complex / Antibody | ||||||
Function / homology | Function and homology information vestibulocochlear nerve structural organization / dorsal root ganglion morphogenesis / ventral trunk neural crest cell migration / sympathetic neuron projection guidance / facioacoustic ganglion development / trigeminal ganglion development / trigeminal nerve structural organization / sensory neuron axon guidance / facial nerve structural organization / gonadotrophin-releasing hormone neuronal migration to the hypothalamus ...vestibulocochlear nerve structural organization / dorsal root ganglion morphogenesis / ventral trunk neural crest cell migration / sympathetic neuron projection guidance / facioacoustic ganglion development / trigeminal ganglion development / trigeminal nerve structural organization / sensory neuron axon guidance / facial nerve structural organization / gonadotrophin-releasing hormone neuronal migration to the hypothalamus / branchiomotor neuron axon guidance / axon extension involved in axon guidance / NrCAM interactions / sympathetic neuron projection extension / Neurophilin interactions with VEGF and VEGFR / sympathetic ganglion development / neural crest cell migration involved in autonomic nervous system development / vascular endothelial growth factor receptor activity / nerve development / semaphorin receptor complex / outflow tract septum morphogenesis / semaphorin receptor activity / regulation of postsynapse organization / negative chemotaxis / cytokine binding / growth factor binding / semaphorin-plexin signaling pathway / positive regulation of endothelial cell proliferation / cellular response to leukemia inhibitory factor / positive regulation of endothelial cell migration / axon guidance / signaling receptor activity / heparin binding / postsynaptic membrane / angiogenesis / cell adhesion / axon / glutamatergic synapse / extracellular region / membrane / identical protein binding / metal ion binding / plasma membrane Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.205 Å | ||||||
Authors | Geng, Y. / Zhai, L. | ||||||
Funding support | 1items
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Citation | Journal: Sci Transl Med / Year: 2023 Title: Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer. Authors: Xu, Z. / Goel, H.L. / Burkart, C. / Burman, L. / Chong, Y.E. / Barber, A.G. / Geng, Y. / Zhai, L. / Wang, M. / Kumar, A. / Menefee, A. / Polizzi, C. / Eide, L. / Rauch, K. / Rahman, J. / ...Authors: Xu, Z. / Goel, H.L. / Burkart, C. / Burman, L. / Chong, Y.E. / Barber, A.G. / Geng, Y. / Zhai, L. / Wang, M. / Kumar, A. / Menefee, A. / Polizzi, C. / Eide, L. / Rauch, K. / Rahman, J. / Hamel, K. / Fogassy, Z. / Klopp-Savino, S. / Paz, S. / Zhang, M. / Cubitt, A. / Nangle, L.A. / Mercurio, A.M. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 8ivw.cif.gz | 695.9 KB | Display | PDBx/mmCIF format |
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PDB format | pdb8ivw.ent.gz | Display | PDB format | |
PDBx/mmJSON format | 8ivw.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/iv/8ivw ftp://data.pdbj.org/pub/pdb/validation_reports/iv/8ivw | HTTPS FTP |
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-Related structure data
Related structure data | 8ivxC C: citing same article (ref.) |
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Similar structure data | Similarity search - Function & homologyF&H Search |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Beg auth comp-ID: CYS / Beg label comp-ID: CYS / Auth asym-ID: A / Label asym-ID: A
NCS ensembles :
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