登録情報 | データベース: PDB / ID: 8ibq |
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タイトル | Bromodomain and Extra-terminal Domain (BET) BRD4 |
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要素 | Bromodomain-containing protein 4 |
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キーワード | DNA BINDING PROTEIN / binds acetylated lysine residues |
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機能・相同性 | 機能・相同性情報
RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II ...RNA polymerase II C-terminal domain binding / negative regulation of DNA damage checkpoint / P-TEFb complex binding / negative regulation by host of viral transcription / positive regulation of T-helper 17 cell lineage commitment / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / RNA polymerase II CTD heptapeptide repeat kinase activity / condensed nuclear chromosome / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / lysine-acetylated histone binding / p53 binding / chromosome / regulation of inflammatory response / positive regulation of canonical NF-kappaB signal transduction / Potential therapeutics for SARS / transcription coactivator activity / transcription cis-regulatory region binding / chromatin remodeling / DNA damage response / chromatin binding / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / enzyme binding / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus類似検索 - 分子機能 Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / : / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site ...Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / : / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.45 Å |
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データ登録者 | Cao, D. / Zhiyan, D. / Xiong, B. |
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資金援助 | 中国, 2件 組織 | 認可番号 | 国 |
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National Natural Science Foundation of China (NSFC) | 82173680 | 中国 | National Natural Science Foundation of China (NSFC) | 81930100 | 中国 |
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引用 | ジャーナル: J.Med.Chem. / 年: 2023 タイトル: Discovery of 1 H -Imidazo[4,5- b ]pyridine Derivatives as Potent and Selective BET Inhibitors for the Management of Neuropathic Pain. 著者: Chen, X. / Cao, D. / Liu, C. / Meng, F. / Zhang, Z. / Xu, R. / Tong, Y. / Xin, Y. / Zhang, W. / Kang, W. / Bao, Q. / Shen, J. / Xiong, B. / You, Q. / Jiang, Z. |
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履歴 | 登録 | 2023年2月10日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2023年10月4日 | Provider: repository / タイプ: Initial release |
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