Entry | Database: PDB / ID: 8i60 |
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Title | Crystal structure of GAS41 YEATS domain in complex with histone H3K27cr |
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Components | - ALA-ARG-KCR-SER-ALA-PRO
- YEATS domain-containing protein 4
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Keywords | PROTEIN BINDING / Histone H3 lysine crotonylation |
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Function / homology | Function and homology information
modification-dependent protein binding / regulation of double-strand break repair / Activation of the TFAP2 (AP-2) family of transcription factors / NuA4 histone acetyltransferase complex / positive regulation of double-strand break repair via homologous recombination / lysine-acetylated histone binding / structural constituent of cytoskeleton / nuclear matrix / nucleosome / mitotic cell cycle ...modification-dependent protein binding / regulation of double-strand break repair / Activation of the TFAP2 (AP-2) family of transcription factors / NuA4 histone acetyltransferase complex / positive regulation of double-strand break repair via homologous recombination / lysine-acetylated histone binding / structural constituent of cytoskeleton / nuclear matrix / nucleosome / mitotic cell cycle / HATs acetylate histones / histone binding / regulation of apoptotic process / nuclear membrane / regulation of cell cycle / chromatin remodeling / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / nucleoplasm / nucleusSimilarity search - Function |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.3 Å |
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Authors | Konuma, T. / Zhou, M.-M. |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Cancer Institute (NIH/NCI) | | United States |
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Citation | Journal: Mol.Cell / Year: 2023 Title: Histone H3 lysine 27 crotonylation mediates gene transcriptional repression in chromatin. Authors: Liu, N. / Konuma, T. / Sharma, R. / Wang, D. / Zhao, N. / Cao, L. / Ju, Y. / Liu, D. / Wang, S. / Bosch, A. / Sun, Y. / Zhang, S. / Ji, D. / Nagatoishi, S. / Suzuki, N. / Kikuchi, M. / ...Authors: Liu, N. / Konuma, T. / Sharma, R. / Wang, D. / Zhao, N. / Cao, L. / Ju, Y. / Liu, D. / Wang, S. / Bosch, A. / Sun, Y. / Zhang, S. / Ji, D. / Nagatoishi, S. / Suzuki, N. / Kikuchi, M. / Wakamori, M. / Zhao, C. / Ren, C. / Zhou, T.J. / Xu, Y. / Meslamani, J. / Fu, S. / Umehara, T. / Tsumoto, K. / Akashi, S. / Zeng, L. / Roeder, R.G. / Walsh, M.J. / Zhang, Q. / Zhou, M.M. |
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History | Deposition | Jan 26, 2023 | Deposition site: PDBJ / Processing site: PDBJ |
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Revision 1.0 | Jul 26, 2023 | Provider: repository / Type: Initial release |
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