登録情報 | データベース: PDB / ID: 8hyi |
---|
タイトル | Crystal structure of human P-cadherin MEC12 (X dimer) in complex with 2-(2-methyl-5-phenyl-1H-indole-3-yl)ethan-1-amine |
---|
要素 | Cadherin-3 |
---|
キーワード | CELL ADHESION / inhibitor |
---|
機能・相同性 | 機能・相同性情報
negative regulation of timing of catagen / positive regulation of melanosome transport / hair cycle process / positive regulation of tyrosinase activity / positive regulation of keratinocyte proliferation / positive regulation of melanin biosynthetic process / cell-cell adhesion mediated by cadherin / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / catenin complex / Adherens junctions interactions ...negative regulation of timing of catagen / positive regulation of melanosome transport / hair cycle process / positive regulation of tyrosinase activity / positive regulation of keratinocyte proliferation / positive regulation of melanin biosynthetic process / cell-cell adhesion mediated by cadherin / calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules / catenin complex / Adherens junctions interactions / retina homeostasis / cell-cell junction assembly / adherens junction organization / positive regulation of insulin-like growth factor receptor signaling pathway / keratinization / homophilic cell adhesion via plasma membrane adhesion molecules / visual perception / negative regulation of transforming growth factor beta receptor signaling pathway / adherens junction / cell morphogenesis / beta-catenin binding / positive regulation of canonical Wnt signaling pathway / cell junction / cell migration / cell adhesion / cadherin binding / response to xenobiotic stimulus / calcium ion binding / positive regulation of gene expression / plasma membrane / cytoplasm類似検索 - 分子機能 Cadherin prodomain / Cadherin prodomain like / Cadherin, Y-type LIR-motif / Cadherin, Y-type LIR-motif / Catenin binding domain superfamily / Cadherin / Cadherin conserved site / Cadherin domain signature. / Cadherin repeats. / Cadherin domain ...Cadherin prodomain / Cadherin prodomain like / Cadherin, Y-type LIR-motif / Cadherin, Y-type LIR-motif / Catenin binding domain superfamily / Cadherin / Cadherin conserved site / Cadherin domain signature. / Cadherin repeats. / Cadherin domain / Cadherins domain profile. / Cadherin-like / Cadherin-like superfamily類似検索 - ドメイン・相同性 2-(2-methyl-5-phenyl-1H-indole-3-yl)ethan-1-amine / Cadherin-3類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.85 Å |
---|
データ登録者 | Senoo, A. / Ito, S. / Ueno, G. / Nagatoishi, S. / Tsumoto, K. |
---|
資金援助 | 日本, 7件 組織 | 認可番号 | 国 |
---|
Japan Society for the Promotion of Science (JSPS) | 19H05766 | 日本 | Japan Agency for Medical Research and Development (AMED) | JP20am0101094 | 日本 | Japan Society for the Promotion of Science (JSPS) | 19J14451 | 日本 | Japan Agency for Medical Research and Development (AMED) | JP20am0101070 | 日本 | Japan Society for the Promotion of Science (JSPS) | 18H05425 | 日本 | Japan Society for the Promotion of Science (JSPS) | 20H02531 | 日本 | Japan Society for the Promotion of Science (JSPS) | 16H02420 | 日本 |
|
---|
引用 | ジャーナル: Protein Sci. / 年: 2023 タイトル: Modulation of a conformational ensemble by a small molecule that inhibits key protein-protein interactions involved in cell adhesion. 著者: Senoo, A. / Nagatoishi, S. / Kuroda, D. / Ito, S. / Ueno, G. / Caaveiro, J.M.M. / Tsumoto, K. |
---|
履歴 | 登録 | 2023年1月6日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
---|
改定 1.0 | 2023年8月30日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2023年9月13日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
---|
改定 1.2 | 2023年10月11日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
---|
|
---|