Entry Database : PDB / ID : 8hl7 Structure visualization Downloads & linksTitle Crystal structure of p97 N/D1 in complex with a valosin-containing protein methyltransferase ComponentsProtein N-lysine methyltransferase METTL21D Transitional endoplasmic reticulum ATPase DetailsKeywords PROTEIN BINDING / VCPKMT / methyltransferase / trimethylated lysine / ASPL / ASPSCR1 / UBXD9 / TUGFunction / homology Function and homology informationFunction Domain/homology Component
peptidyl-lysine methylation / peptidyl-lysine trimethylation / negative regulation of ATP-dependent activity / positive regulation of Lys63-specific deubiquitinase activity / protein-lysine N-methyltransferase activity / flavin adenine dinucleotide catabolic process / positive regulation of oxidative phosphorylation / VCP-NSFL1C complex / endosome to lysosome transport via multivesicular body sorting pathway / endoplasmic reticulum stress-induced pre-emptive quality control ... peptidyl-lysine methylation / peptidyl-lysine trimethylation / negative regulation of ATP-dependent activity / positive regulation of Lys63-specific deubiquitinase activity / protein-lysine N-methyltransferase activity / flavin adenine dinucleotide catabolic process / positive regulation of oxidative phosphorylation / VCP-NSFL1C complex / endosome to lysosome transport via multivesicular body sorting pathway / endoplasmic reticulum stress-induced pre-emptive quality control / cellular response to arsenite ion / Derlin-1 retrotranslocation complex / BAT3 complex binding / protein-DNA covalent cross-linking repair / positive regulation of protein K63-linked deubiquitination / deubiquitinase activator activity / mitotic spindle disassembly / aggresome assembly / VCP-NPL4-UFD1 AAA ATPase complex / regulation of protein localization to chromatin / ubiquitin-modified protein reader activity / vesicle-fusing ATPase / NADH metabolic process / cellular response to misfolded protein / stress granule disassembly / positive regulation of mitochondrial membrane potential / negative regulation of protein localization to chromatin / K48-linked polyubiquitin modification-dependent protein binding / retrograde protein transport, ER to cytosol / regulation of aerobic respiration / positive regulation of ATP biosynthetic process / regulation of synapse organization / ATPase complex / histone methyltransferase activity / ubiquitin-specific protease binding / ubiquitin-like protein ligase binding / MHC class I protein binding / autophagosome maturation / RHOH GTPase cycle / polyubiquitin modification-dependent protein binding / HSF1 activation / proteasomal protein catabolic process / endoplasmic reticulum to Golgi vesicle-mediated transport / translesion synthesis / Protein methylation / interstrand cross-link repair / ERAD pathway / ATP metabolic process / negative regulation of smoothened signaling pathway / endoplasmic reticulum unfolded protein response / Attachment and Entry / proteasome complex / viral genome replication / Transferases; Transferring one-carbon groups; Methyltransferases / lipid droplet / Josephin domain DUBs / N-glycan trimming in the ER and Calnexin/Calreticulin cycle / macroautophagy / Hh mutants are degraded by ERAD / Hedgehog ligand biogenesis / Defective CFTR causes cystic fibrosis / Translesion Synthesis by POLH / positive regulation of protein-containing complex assembly / establishment of protein localization / positive regulation of non-canonical NF-kappaB signal transduction / ABC-family proteins mediated transport / activation of cysteine-type endopeptidase activity involved in apoptotic process / ADP binding / autophagy / Aggrephagy / cytoplasmic stress granule / positive regulation of canonical Wnt signaling pathway / positive regulation of protein catabolic process / azurophil granule lumen / KEAP1-NFE2L2 pathway / double-strand break repair / Ovarian tumor domain proteases / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / E3 ubiquitin ligases ubiquitinate target proteins / ATPase binding / Neddylation / site of double-strand break / cellular response to heat / protein phosphatase binding / ubiquitin-dependent protein catabolic process / proteasome-mediated ubiquitin-dependent protein catabolic process / secretory granule lumen / regulation of apoptotic process / ficolin-1-rich granule lumen / Attachment and Entry / protein ubiquitination / protein domain specific binding / intracellular membrane-bounded organelle / DNA repair / DNA damage response / ubiquitin protein ligase binding / lipid binding / glutamatergic synapse / endoplasmic reticulum membrane / Neutrophil degranulation Similarity search - Function Lysine methyltransferase / Lysine methyltransferase / AAA ATPase, CDC48 family / Cell division protein 48 (CDC48), N-terminal domain / CDC48, N-terminal subdomain / Cell division protein 48 (CDC48) N-terminal domain / CDC48, domain 2 / Cell division protein 48 (CDC48), domain 2 / Cell division protein 48 (CDC48) domain 2 / CDC48 domain 2-like superfamily ... Lysine methyltransferase / Lysine methyltransferase / AAA ATPase, CDC48 family / Cell division protein 48 (CDC48), N-terminal domain / CDC48, N-terminal subdomain / Cell division protein 48 (CDC48) N-terminal domain / CDC48, domain 2 / Cell division protein 48 (CDC48), domain 2 / Cell division protein 48 (CDC48) domain 2 / CDC48 domain 2-like superfamily / : / Aspartate decarboxylase-like domain superfamily / AAA ATPase, AAA+ lid domain / AAA+ lid domain / ATPase, AAA-type, conserved site / AAA-protein family signature. / ATPase family associated with various cellular activities (AAA) / ATPase, AAA-type, core / S-adenosyl-L-methionine-dependent methyltransferase superfamily / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / P-loop containing nucleoside triphosphate hydrolase Similarity search - Domain/homology ACETATE ION / ADENOSINE-5'-DIPHOSPHATE / FORMIC ACID / S-ADENOSYL-L-HOMOCYSTEINE / Transitional endoplasmic reticulum ATPase / Protein N-lysine methyltransferase METTL21D Similarity search - ComponentBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.8 Å DetailsAuthors Kang, W. / Yang, J.K. Funding support Korea, Republic Of, 2items Details Hide detailsOrganization Grant number Country National Research Foundation (NRF, Korea) 2021R1A6A1A10044154 Korea, Republic Of National Research Foundation (NRF, Korea) 2022R1C1C1004221 Korea, Republic Of
CitationJournal : Iscience / Year : 2023Title : Structural basis for recognition and methylation of p97 by METTL21D, a valosin-containing protein lysine methyltransferase.Authors : Nguyen, T.Q. / Koh, S. / Kwon, J. / Jang, S. / Kang, W. / Yang, J.K. History Deposition Nov 29, 2022 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Jul 12, 2023 Provider : repository / Type : Initial releaseRevision 1.1 Aug 2, 2023 Group : Database references / Category : citationItem : _citation.journal_volume / _citation.page_last ... _citation.journal_volume / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title
Show all Show less