登録情報 | データベース: PDB / ID: 8gh4 |
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タイトル | Complex of Adam 10 disentegrin cysteine rich domains with human monoclonal antibody |
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要素 | - Antibody heavy chain
- Antibody light chain
- Disintegrin and metalloproteinase domain-containing protein 10
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キーワード | IMMUNE SYSTEM / colorectal cancer / adam 10 / human monoclonal antibody |
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機能・相同性 | 機能・相同性情報
Degradation of the extracellular matrix / ADAM10 endopeptidase / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / Post-translational protein phosphorylation / metalloendopeptidase activity involved in amyloid precursor protein catabolic process / negative regulation of cell adhesion / clathrin-coated vesicle / Neutrophil degranulation / Golgi-associated vesicle / amyloid precursor protein catabolic process ...Degradation of the extracellular matrix / ADAM10 endopeptidase / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / Post-translational protein phosphorylation / metalloendopeptidase activity involved in amyloid precursor protein catabolic process / negative regulation of cell adhesion / clathrin-coated vesicle / Neutrophil degranulation / Golgi-associated vesicle / amyloid precursor protein catabolic process / membrane protein ectodomain proteolysis / Notch signaling pathway / synaptic membrane / adherens junction / protein processing / metalloendopeptidase activity / SH3 domain binding / metallopeptidase activity / endopeptidase activity / in utero embryonic development / protein phosphorylation / Golgi membrane / axon / dendrite / protein kinase binding / cell surface / Golgi apparatus / protein homodimerization activity / nucleus / metal ion binding / plasma membrane / cytoplasm類似検索 - 分子機能 : / ADAM10, cysteine-rich domain / ADAM10/ADAM17 catalytic domain / : / Metallo-peptidase family M12B Reprolysin-like / Disintegrin / Disintegrin domain profile. / Homologues of snake disintegrins / Disintegrin domain / Disintegrin domain superfamily ...: / ADAM10, cysteine-rich domain / ADAM10/ADAM17 catalytic domain / : / Metallo-peptidase family M12B Reprolysin-like / Disintegrin / Disintegrin domain profile. / Homologues of snake disintegrins / Disintegrin domain / Disintegrin domain superfamily / Peptidase M12B, ADAM/reprolysin / ADAM type metalloprotease domain profile. / Metallopeptidase, catalytic domain superfamily / Neutral zinc metallopeptidases, zinc-binding region signature.類似検索 - ドメイン・相同性 Disintegrin and metalloproteinase domain-containing protein 10類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト)
![](img/tx_mammal.gif) Bos taurus (ウシ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.8 Å |
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データ登録者 | Nikolov, D.B. / Saha, N. / Xu, K. / Goldgur, Y. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute on Aging (NIH/NIA) | R21AG08068501 | 米国 |
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引用 | ジャーナル: Biomed Pharmacother / 年: 2023 タイトル: Fully human monoclonal antibody targeting activated ADAM10 on colorectal cancer cells. 著者: Saha, N. / Baek, D.S. / Mendoza, R.P. / Robev, D. / Xu, Y. / Goldgur, Y. / De La Cruz, M.J. / de Stanchina, E. / Janes, P.W. / Xu, K. / Dimitrov, D.S. / Nikolov, D.B. |
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履歴 | 登録 | 2023年3月9日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2023年8月30日 | Provider: repository / タイプ: Initial release |
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