Entry | Database: PDB / ID: 8gd4 |
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Title | Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with DMFO Inhibitor 6 |
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Components | Hdac6 protein |
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Keywords | HYDROLASE / histone deacetylase / inhibitor / metallohydrolase |
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Function / homology | Function and homology information
tubulin deacetylase activity / swimming behavior / definitive hemopoiesis / protein lysine deacetylase activity / regulation of tubulin deacetylation / histone deacetylase activity / potassium ion binding / histone deacetylase complex / hematopoietic progenitor cell differentiation / angiogenesis ...tubulin deacetylase activity / swimming behavior / definitive hemopoiesis / protein lysine deacetylase activity / regulation of tubulin deacetylation / histone deacetylase activity / potassium ion binding / histone deacetylase complex / hematopoietic progenitor cell differentiation / angiogenesis / negative regulation of transcription by RNA polymerase II / zinc ion bindingSimilarity search - Function Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger / Zinc finger, UBP-type / Zn-finger in ubiquitin-hydrolases and other protein / Zinc finger UBP-type profile. / Histone deacetylase family / Histone deacetylase domain / Histone deacetylase domain superfamily / Histone deacetylase domain / Ureohydrolase domain superfamily / Zinc finger, RING/FYVE/PHD-typeSimilarity search - Domain/homology |
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Biological species | ![](img/tx_fish.gif) Danio rerio (zebrafish) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2 Å |
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Authors | Watson, P.R. / Craigin, A.D. / Christianson, D.W. |
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Funding support | United States, 1items Organization | Grant number | Country |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | GM49758 | United States |
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Citation | Journal: J.Med.Chem. / Year: 2023 Title: Difluoromethyl-1,3,4-oxadiazoles Are Selective, Mechanism-Based, and Essentially Irreversible Inhibitors of Histone Deacetylase 6 . Authors: Konig, B. / Watson, P.R. / Ressing, N. / Cragin, A.D. / Schaker-Hubner, L. / Christianson, D.W. / Hansen, F.K. |
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History | Deposition | Mar 3, 2023 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Oct 4, 2023 | Provider: repository / Type: Initial release |
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Revision 1.1 | Oct 18, 2023 | Group: Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID / _citation_author.name |
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Revision 1.2 | Oct 25, 2023 | Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.identifier_ORCID |
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