Entry Database : PDB / ID : 8gbu Structure visualization Downloads & linksTitle Hepatitis B capsid Y132A mutant with compound AB-506 ComponentsCapsid protein Details Keywords VIRAL PROTEIN / Hepatitis B / Y132A / capsidFunction / homology Function and homology informationFunction Domain/homology Component
microtubule-dependent intracellular transport of viral material towards nucleus / T=4 icosahedral viral capsid / viral penetration into host nucleus / host cell / host cell cytoplasm / symbiont entry into host cell / structural molecule activity / DNA binding / RNA binding Similarity search - FunctionBiological species Hepatitis B virusMethod X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.5 Å DetailsAuthors Horanyi, P.S. / Mayclin, S.J. Funding support 1items Details Hide detailsOrganization Grant number Country Not funded
CitationJournal : Bioorg.Med.Chem.Lett. / Year : 2023Title : Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506.Authors: Cole, A.G. / Kultgen, S.G. / Mani, N. / Quintero, J.G. / Yi Fan, K. / Ardzinski, A. / Stever, K. / Dorsey, B.D. / Phelps, J.R. / Lee, A.C.H. / Thi, E.P. / Chiu, T. / Tang, S. / Horanyi, P.S. ... Authors : Cole, A.G. / Kultgen, S.G. / Mani, N. / Quintero, J.G. / Yi Fan, K. / Ardzinski, A. / Stever, K. / Dorsey, B.D. / Phelps, J.R. / Lee, A.C.H. / Thi, E.P. / Chiu, T. / Tang, S. / Horanyi, P.S. / Mayclin, S.J. / Harasym, T.O. / Sofia, M.J. History Deposition Feb 28, 2023 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Sep 6, 2023 Provider : repository / Type : Initial releaseRevision 1.1 Sep 20, 2023 Group : Database references / Category : citation / Item : _citation.journal_volume
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