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Title | Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 94, Page 129456-129456, Year 2023 |
Publish date | Feb 28, 2023 (structure data deposition date) |
Authors | Cole, A.G. / Kultgen, S.G. / Mani, N. / Quintero, J.G. / Yi Fan, K. / Ardzinski, A. / Stever, K. / Dorsey, B.D. / Phelps, J.R. / Lee, A.C.H. ...Cole, A.G. / Kultgen, S.G. / Mani, N. / Quintero, J.G. / Yi Fan, K. / Ardzinski, A. / Stever, K. / Dorsey, B.D. / Phelps, J.R. / Lee, A.C.H. / Thi, E.P. / Chiu, T. / Tang, S. / Horanyi, P.S. / Mayclin, S.J. / Harasym, T.O. / Sofia, M.J. |
External links | Bioorg. Med. Chem. Lett. / PubMed:37633618 |
Methods | X-ray diffraction |
Resolution | 2.5 Å |
Structure data | PDB-8gbu: |
Chemicals | ChemComp-YWE: ChemComp-EDO: ChemComp-HOH: |
Source |
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Keywords | VIRAL PROTEIN / Hepatitis B / Y132A / capsid |