Entry Database : PDB / ID : 8g5e Structure visualization Downloads & linksTitle Crystal Structure of SETDB1 Tudor domain in complex with UNC6535 ComponentsHistone-lysine N-methyltransferase SETDB1 Details Keywords TRANSFERASE / SETDB1 / epigenetics / methyllysine reader / SGC / Structural Genomics / PSI:Biology / Protein Structure Initiative / Structural Genomics ConsortiumFunction / homology Function and homology informationFunction Domain/homology Component
[histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase / histone H3K9 trimethyltransferase activity / histone H3K9 monomethyltransferase activity / positive regulation of DNA methylation-dependent heterochromatin formation / histone H3K9 methyltransferase activity / histone H3K9me2 methyltransferase activity / negative regulation of single stranded viral RNA replication via double stranded DNA intermediate / heterochromatin organization / promoter-specific chromatin binding / PKMTs methylate histone lysines ... [histone H3]-N6,N6-dimethyl-lysine9 N-methyltransferase / histone H3K9 trimethyltransferase activity / histone H3K9 monomethyltransferase activity / positive regulation of DNA methylation-dependent heterochromatin formation / histone H3K9 methyltransferase activity / histone H3K9me2 methyltransferase activity / negative regulation of single stranded viral RNA replication via double stranded DNA intermediate / heterochromatin organization / promoter-specific chromatin binding / PKMTs methylate histone lysines / chromosome / methylation / negative regulation of gene expression / intracellular membrane-bounded organelle / chromatin binding / DNA binding / zinc ion binding / nucleoplasm / nucleus / cytoplasm Similarity search - Function Histone-lysine N-methyltransferase SETDB1 / Domain of unknown function DUF5604 / : / Domain of unknown function (DUF5604) / Histone-lysine N-methyltransferase (EC 2.1.1.43) family profile. / Histone methyltransferase, Tudor domain 1 / Histone methyltransferase, Tudor domain 2 / Histone methyltransferase Tudor domain / Histone methyltransferase Tudor domain 1 / Pre-SET domain ... Histone-lysine N-methyltransferase SETDB1 / Domain of unknown function DUF5604 / : / Domain of unknown function (DUF5604) / Histone-lysine N-methyltransferase (EC 2.1.1.43) family profile. / Histone methyltransferase, Tudor domain 1 / Histone methyltransferase, Tudor domain 2 / Histone methyltransferase Tudor domain / Histone methyltransferase Tudor domain 1 / Pre-SET domain / Pre-SET motif / Pre-SET domain profile. / N-terminal to some SET domains / Tudor domain / Tudor domain / Post-SET domain / Post-SET domain profile. / Methyl-CpG binding domain / Methyl-CpG DNA binding / Methyl-CpG binding domain / Methyl-CpG-binding domain (MBD) profile. / DNA-binding domain superfamily / SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain / SET domain superfamily / SET domain / SET domain profile. / SET domain Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / FOURIER SYNTHESIS / Resolution : 1.98 Å DetailsAuthors Beldar, S. / Dong, A. / Brown, P.J. / Arrowsmith, C.H. / Edwards, A.M. / Halabelian, L. / Structural Genomics Consortium (SGC) Funding support Canada, 1items Details Hide detailsOrganization Grant number Country Other private Canada
CitationJournal : To be published Title : Crystal Structure of SETDB1 Tudor domain in complex with UNC6535Authors : Beldar, S. / Dong, A. / Brown, P.J. / Arrowsmith, C.H. / Edwards, A.M. / Halabelian, L. History Deposition Feb 13, 2023 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Feb 22, 2023 Provider : repository / Type : Initial releaseRevision 1.1 May 22, 2024 Group : Data collection / Category : chem_comp_atom / chem_comp_bond
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