登録情報 | データベース: PDB / ID: 8fpt |
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タイトル | STRUCTURE OF ALPHA-SYNUCLEIN FIBRILS DERIVED FROM HUMAN LEWY BODY DEMENTIA TISSUE |
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要素 | Alpha-synuclein |
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キーワード | PROTEIN FIBRIL / AMYLOID / LEWY BODY DEMENTIA / POLYMORPHISM / PARKINSON / STRUCTURAL PROTEIN |
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機能・相同性 | 機能・相同性情報
negative regulation of mitochondrial electron transport, NADH to ubiquinone / neutral lipid metabolic process / regulation of phospholipase activity / negative regulation of monooxygenase activity / regulation of acyl-CoA biosynthetic process / negative regulation of dopamine uptake involved in synaptic transmission / negative regulation of norepinephrine uptake / positive regulation of glutathione peroxidase activity / positive regulation of SNARE complex assembly / positive regulation of hydrogen peroxide catabolic process ...negative regulation of mitochondrial electron transport, NADH to ubiquinone / neutral lipid metabolic process / regulation of phospholipase activity / negative regulation of monooxygenase activity / regulation of acyl-CoA biosynthetic process / negative regulation of dopamine uptake involved in synaptic transmission / negative regulation of norepinephrine uptake / positive regulation of glutathione peroxidase activity / positive regulation of SNARE complex assembly / positive regulation of hydrogen peroxide catabolic process / supramolecular fiber / negative regulation of transporter activity / mitochondrial membrane organization / negative regulation of chaperone-mediated autophagy / regulation of reactive oxygen species biosynthetic process / positive regulation of protein localization to cell periphery / regulation of synaptic vesicle recycling / negative regulation of platelet-derived growth factor receptor signaling pathway / negative regulation of exocytosis / regulation of glutamate secretion / response to iron(II) ion / regulation of norepinephrine uptake / SNARE complex assembly / positive regulation of neurotransmitter secretion / dopamine biosynthetic process / regulation of locomotion / positive regulation of inositol phosphate biosynthetic process / synaptic vesicle priming / regulation of macrophage activation / negative regulation of microtubule polymerization / synaptic vesicle transport / dopamine uptake involved in synaptic transmission / dynein complex binding / regulation of dopamine secretion / positive regulation of receptor recycling / protein kinase inhibitor activity / negative regulation of thrombin-activated receptor signaling pathway / response to type II interferon / cuprous ion binding / positive regulation of exocytosis / synaptic vesicle exocytosis / positive regulation of endocytosis / kinesin binding / cysteine-type endopeptidase inhibitor activity involved in apoptotic process / response to magnesium ion / synaptic vesicle endocytosis / regulation of presynapse assembly / negative regulation of serotonin uptake / alpha-tubulin binding / phospholipid metabolic process / supramolecular fiber organization / axon terminus / mitochondrial ATP synthesis coupled electron transport / inclusion body / fatty acid metabolic process / cellular response to copper ion / cellular response to epinephrine stimulus / Hsp70 protein binding / response to interleukin-1 / adult locomotory behavior / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / positive regulation of release of sequestered calcium ion into cytosol / SNARE binding / excitatory postsynaptic potential / long-term synaptic potentiation / phosphoprotein binding / protein tetramerization / regulation of transmembrane transporter activity / synapse organization / microglial cell activation / negative regulation of protein kinase activity / regulation of long-term neuronal synaptic plasticity / protein destabilization / ferrous iron binding / tau protein binding / positive regulation of protein serine/threonine kinase activity / PKR-mediated signaling / receptor internalization / phospholipid binding / activation of cysteine-type endopeptidase activity involved in apoptotic process / synaptic vesicle membrane / positive regulation of inflammatory response / positive regulation of peptidyl-serine phosphorylation / actin cytoskeleton / actin binding / cellular response to oxidative stress / histone binding / cell cortex / growth cone / chemical synaptic transmission / neuron apoptotic process / negative regulation of neuron apoptotic process / transcription cis-regulatory region binding / postsynapse / amyloid fibril formation / response to lipopolysaccharide / molecular adaptor activity / oxidoreductase activity / lysosome / response to xenobiotic stimulus類似検索 - 分子機能 |
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生物種 | Homo sapiens (ヒト) |
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手法 | 個体NMR / simulated annealing |
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データ登録者 | Barclay, A.M. / Dhavale, D.D. / Borcik, C.G. / Rau, M.J. / Basore, K. / Milchberg, M.H. / Warmuth, O.A. / Kotzbauer, P.T. / Rienstra, C.M. / Schwieters, C.D. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | | 米国 |
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引用 | ジャーナル: Biorxiv / 年: 2023 タイトル: Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue. 著者: Dhavale, D.D. / Barclay, A.M. / Borcik, C.G. / Basore, K. / Gordon, I.R. / Liu, J. / Milchberg, M.H. / Oa Shea, J. / Rau, M.J. / Smith, Z. / Sen, S. / Summers, B. / Smith, J. / Warmuth, O.A. ...著者: Dhavale, D.D. / Barclay, A.M. / Borcik, C.G. / Basore, K. / Gordon, I.R. / Liu, J. / Milchberg, M.H. / Oa Shea, J. / Rau, M.J. / Smith, Z. / Sen, S. / Summers, B. / Smith, J. / Warmuth, O.A. / Chen, Q. / Fitzpatrick, J.A.J. / Schwieters, C.D. / Tajkhorshid, E. / Rienstra, C.M. / Kotzbauer, P.T. |
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履歴 | 登録 | 2023年1月5日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2023年2月22日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年5月15日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 / Item: _database_2.pdbx_DOI |
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