登録情報 | データベース: PDB / ID: 8f93 |
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タイトル | WDR5 covalently modified at Y228 by (R)-2-SF |
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要素 | WD repeat-containing protein 5 |
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キーワード | GENE REGULATION/INHIBITOR / covalent inhibition / Y228 / sulfonyl fluoride / PPI / GENE REGULATION / GENE REGULATION-INHIBITOR complex |
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機能・相同性 | 機能・相同性情報
MLL3/4 complex / Set1C/COMPASS complex / MLL1/2 complex / ATAC complex / NSL complex / histone H3K4 methyltransferase activity / Cardiogenesis / regulation of tubulin deacetylation / histone methyltransferase complex / Formation of WDR5-containing histone-modifying complexes ...MLL3/4 complex / Set1C/COMPASS complex / MLL1/2 complex / ATAC complex / NSL complex / histone H3K4 methyltransferase activity / Cardiogenesis / regulation of tubulin deacetylation / histone methyltransferase complex / Formation of WDR5-containing histone-modifying complexes / regulation of cell division / regulation of embryonic development / MLL1 complex / histone acetyltransferase complex / positive regulation of gluconeogenesis / methylated histone binding / transcription initiation-coupled chromatin remodeling / skeletal system development / gluconeogenesis / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / mitotic spindle / PKMTs methylate histone lysines / RMTs methylate histone arginines / Activation of anterior HOX genes in hindbrain development during early embryogenesis / Neddylation / HATs acetylate histones / histone binding / regulation of cell cycle / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / nucleoplasm / nucleus類似検索 - 分子機能 G-protein beta WD-40 repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD domain, G-beta repeat / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.3 Å |
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データ登録者 | Taunton, J. / Craven, G.B. / Chen, Y. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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Other private | | 米国 |
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引用 | ジャーナル: Nat.Chem. / 年: 2023 タイトル: Direct mapping of ligandable tyrosines and lysines in cells with chiral sulfonyl fluoride probes. 著者: Chen, Y. / Craven, G.B. / Kamber, R.A. / Cuesta, A. / Zhersh, S. / Moroz, Y.S. / Bassik, M.C. / Taunton, J. |
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履歴 | 登録 | 2022年11月23日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2023年5月31日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年8月2日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed ..._citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID |
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改定 1.2 | 2023年10月25日 | Group: Data collection カテゴリ: chem_comp_atom / chem_comp_bond / diffrn_detector Item: _diffrn_detector.detector / _diffrn_detector.type |
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改定 1.3 | 2023年11月15日 | Group: Database references / カテゴリ: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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