登録情報 | データベース: PDB / ID: 8f8y |
---|
タイトル | PHF2 (PHD+JMJ) in Complex with VRK1 N-Terminal Peptide |
---|
要素 | - Lysine-specific demethylase PHF2
- Serine/threonine-protein kinase VRK1 N-terminus peptide
|
---|
キーワード | OXIDOREDUCTASE/TRANSFERASE / Methyl-lysine binding / aromatic cage / plant homeodomain / PHD / Jumonji domain / plant homeodomain finger 2 / PHF2 / histone H3 lysine 4 tri-methylation / H3K4me3 / PROTEIN BINDING / OXIDOREDUCTASE-TRANSFERASE complex |
---|
機能・相同性 | 機能・相同性情報
histone H4K20 demethylase activity / histone H2AX kinase activity / Golgi disassembly / Cajal body organization / negative regulation of rDNA heterochromatin formation / Nuclear Envelope Breakdown / positive regulation of protein localization to chromatin / 酸化還元酵素; 電子対供与作用を持つ; 分子酸素を取り込むないしは分子酸素を還元する; 2-オキソグルタル酸類を片方の電子供与体とする; 酸素分をそれぞれの電子供与体に取り込む / mitotic nuclear membrane disassembly / protein demethylation ...histone H4K20 demethylase activity / histone H2AX kinase activity / Golgi disassembly / Cajal body organization / negative regulation of rDNA heterochromatin formation / Nuclear Envelope Breakdown / positive regulation of protein localization to chromatin / 酸化還元酵素; 電子対供与作用を持つ; 分子酸素を取り込むないしは分子酸素を還元する; 2-オキソグルタル酸類を片方の電子供与体とする; 酸素分をそれぞれの電子供与体に取り込む / mitotic nuclear membrane disassembly / protein demethylation / Golgi stack / Initiation of Nuclear Envelope (NE) Reformation / regulation of neuron migration / nucleosomal DNA binding / histone H3K9 demethylase activity / : / Cajal body / transcription initiation-coupled chromatin remodeling / liver development / transcription coregulator activity / HDMs demethylate histones / kinetochore / neuron projection development / kinase activity / histone H3T3 kinase activity / histone H3S10 kinase activity / protein autophosphorylation / histone binding / transcription coactivator activity / non-specific serine/threonine protein kinase / protein kinase activity / protein phosphorylation / chromatin remodeling / iron ion binding / cell division / protein serine kinase activity / protein serine/threonine kinase activity / DNA damage response / regulation of transcription by RNA polymerase II / protein kinase binding / chromatin / nucleolus / signal transduction / zinc ion binding / nucleoplasm / ATP binding / nucleus / cytosol / cytoplasm類似検索 - 分子機能 Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #1360 / Jumonji, helical domain / Jumonji helical domain / : / : / Cupin / JmjC domain, hydroxylase / A domain family that is part of the cupin metalloenzyme superfamily. / JmjC domain / JmjC domain profile. ...Methane Monooxygenase Hydroxylase; Chain G, domain 1 - #1360 / Jumonji, helical domain / Jumonji helical domain / : / : / Cupin / JmjC domain, hydroxylase / A domain family that is part of the cupin metalloenzyme superfamily. / JmjC domain / JmjC domain profile. / Zinc finger, PHD-type, conserved site / PHD-finger / Zinc finger PHD-type signature. / Zinc finger PHD-type profile. / Methane Monooxygenase Hydroxylase; Chain G, domain 1 / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / Zinc finger, FYVE/PHD-type / Zinc finger, RING/FYVE/PHD-type / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Jelly Rolls / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Up-down Bundle / Sandwich / Mainly Beta / Mainly Alpha類似検索 - ドメイン・相同性 Lysine-specific demethylase PHF2 / Serine/threonine-protein kinase VRK1類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.06 Å |
---|
データ登録者 | Horton, J.R. / Cheng, X. |
---|
資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
---|
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | R35GM134744 | 米国 | Cancer Prevention and Research Institute of Texas (CPRIT) | RR160029 | 米国 |
|
---|
引用 | ジャーナル: J.Biol.Chem. / 年: 2022 タイトル: A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2. 著者: Horton, J.R. / Zhou, J. / Chen, Q. / Zhang, X. / Bedford, M.T. / Cheng, X. |
---|
履歴 | 登録 | 2022年11月22日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2023年1月18日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2023年2月8日 | Group: Database references / カテゴリ: citation / Item: _citation.journal_volume |
---|
|
---|