PDB-8ewv: DNA-encoded library (DEL)-enabled discovery of proximity inducing...

基本情報

• 登録情報: データベース: PDB / ID: 8ewv
• タイトル: DNA-encoded library (DEL)-enabled discovery of proximity inducing small molecules

要素

• Bromodomain-containing protein 4
• Elongin-B
• Elongin-C
• von Hippel-Lindau disease tumor suppressor

• キーワード: APOPTOSIS / molecular glue / bifunctional compound / BRD4 / VCB / DNA-encoded libraries

機能・相同性

分子機能:

regulation of cellular response to hypoxia / negative regulation of receptor signaling pathway via JAK-STAT / RHOBTB3 ATPase cycle / transcription elongation factor activity / target-directed miRNA degradation / elongin complex / Replication of the SARS-CoV-1 genome / VCB complex / Cul5-RING ubiquitin ligase complex / intracellular membraneless organelle / Cul2-RING ubiquitin ligase complex / SUMOylation of ubiquitinylation proteins / RNA polymerase II C-terminal domain binding / P-TEFb complex binding / negative regulation of DNA damage checkpoint / histone H4 reader activity / negative regulation of transcription elongation by RNA polymerase II / Pausing and recovery of Tat-mediated HIV elongation / Tat-mediated HIV elongation arrest and recovery / HIV elongation arrest and recovery / Pausing and recovery of HIV elongation / host-mediated suppression of viral transcription / positive regulation of G2/M transition of mitotic cell cycle / negative regulation of signal transduction / positive regulation of T-helper 17 cell lineage commitment / Tat-mediated elongation of the HIV-1 transcript / Formation of HIV-1 elongation complex containing HIV-1 Tat / ubiquitin-like ligase-substrate adaptor activity / Formation of HIV elongation complex in the absence of HIV Tat / RNA Polymerase II Transcription Elongation / Formation of RNA Pol II elongation complex / : / negative regulation of TORC1 signaling / RNA Polymerase II Pre-transcription Events / RNA polymerase II CTD heptapeptide repeat kinase activity / protein serine/threonine kinase binding / negative regulation of autophagy / transcription corepressor binding / condensed nuclear chromosome / transcription coregulator activity / TP53 Regulates Transcription of DNA Repair Genes / positive regulation of cell differentiation / transcription initiation at RNA polymerase II promoter / transcription elongation by RNA polymerase II / positive regulation of transcription elongation by RNA polymerase II / Vif-mediated degradation of APOBEC3G / Inactivation of CSF3 (G-CSF) signaling / Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha / Evasion by RSV of host interferon responses / Regulation of expression of SLITs and ROBOs / cell morphogenesis / ubiquitin-protein transferase activity / p53 binding / transcription corepressor activity / Antigen processing: Ubiquitination & Proteasome degradation / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / chromosome / Neddylation / microtubule cytoskeleton / regulation of gene expression / regulation of inflammatory response / protein-containing complex assembly / Replication of the SARS-CoV-2 genome / ubiquitin-dependent protein catabolic process / histone binding / protein-macromolecule adaptor activity / cellular response to hypoxia / DNA-binding transcription factor binding / amyloid fibril formation / molecular adaptor activity / Potential therapeutics for SARS / proteasome-mediated ubiquitin-dependent protein catabolic process / transcription coactivator activity / positive regulation of canonical NF-kappaB signal transduction / transcription cis-regulatory region binding / protein stabilization / cilium / protein ubiquitination / chromatin remodeling / negative regulation of cell population proliferation / negative regulation of gene expression / protein serine/threonine kinase activity / DNA damage response / ubiquitin protein ligase binding / chromatin binding / regulation of DNA-templated transcription / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / chromatin / positive regulation of DNA-templated transcription / enzyme binding / endoplasmic reticulum / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / mitochondrion / proteolysis / nucleoplasm / nucleus / plasma membrane / cytosol

ドメイン・相同性:

von Hippel-Lindau disease tumour suppressor, beta/alpha domain / von Hippel-Lindau disease tumour suppressor, alpha domain / von Hippel-Lindau disease tumour suppressor, beta domain / VHL superfamily / von Hippel-Lindau disease tumour suppressor, alpha domain superfamily / von Hippel-Lindau disease tumour suppressor, beta domain superfamily / VHL beta domain / VHL box domain / Elongin-C / Elongin B / S-phase kinase-associated protein 1-like / SKP1 component, POZ domain / Skp1 family, tetramerisation domain / Found in Skp1 protein family / Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / Brdt, bromodomain, repeat I / Brdt, bromodomain, repeat II / NET domain superfamily / NET domain profile. / : / NET domain / Bromodomain extra-terminal - transcription regulation / SKP1/BTB/POZ domain superfamily / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / bromo domain / Bromodomain / Bromodomain (BrD) profile. / Bromodomain-like superfamily / Ubiquitin family / Ubiquitin homologues / Ubiquitin domain profile. / Ubiquitin-like domain / Ubiquitin-like domain superfamily

構成要素:

Chem-X5K / Bromodomain-containing protein 4 / von Hippel-Lindau disease tumor suppressor / Elongin-C / Elongin-B

• 生物種: Homo sapiens (ヒト)
• 手法: X線回折 / シンクロトロン / 分子置換 / 解像度: 3.4 Å
• データ登録者: Schreiber, S.L. / Shu, W. / Ma, X. / Michaud, G. / Bonazzi, S. / Berst, F.

資金援助

米国, 1件

組織	認可番号	国
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)	R35GM127045	米国

• 引用: ジャーナル: Nat.Chem.Biol. / 年: 2024; タイトル: DNA-encoded library-enabled discovery of proximity-inducing small molecules.; 著者: Mason, J.W. / Chow, Y.T. / Hudson, L. / Tutter, A. / Michaud, G. / Westphal, M.V. / Shu, W. / Ma, X. / Tan, Z.Y. / Coley, C.W. / Clemons, P.A. / Bonazzi, S. / Berst, F. / Briner, K. / Liu, S. / Zecri, F.J. / Schreiber, S.L.

履歴

登録	2022年10月24日	登録サイト: RCSB / 処理サイト: RCSB
改定 1.0	2023年10月4日	Provider: repository / タイプ: Initial release
改定 1.1	2023年11月15日	Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year
改定 1.2	2024年2月14日	Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.year / _citation_author.identifier_ORCID

集合体

登録構造単位

A: Elongin-B

B: Elongin-C

C: von Hippel-Lindau disease tumor suppressor

D: Bromodomain-containing protein 4

E: Elongin-B

F: Elongin-C

G: von Hippel-Lindau disease tumor suppressor

H: Bromodomain-containing protein 4

I: Elongin-B

J: Elongin-C

K: von Hippel-Lindau disease tumor suppressor

L: Bromodomain-containing protein 4

M: Elongin-B

N: Elongin-C

O: von Hippel-Lindau disease tumor suppressor

P: Bromodomain-containing protein 4

Q: Elongin-B

R: Elongin-C

S: von Hippel-Lindau disease tumor suppressor

T: Bromodomain-containing protein 4

U: Elongin-B

V: Elongin-C

W: von Hippel-Lindau disease tumor suppressor

X: Bromodomain-containing protein 4

ヘテロ分子

概要:

• 352 kDa, 24 ポリマー

構成要素の詳細:

	分子量 (理論値)	分子数
合計 (水以外)	352,459	30
ポリマ－	346,817	24
非ポリマー	5,641	6
水	0	0

1

A: Elongin-B

B: Elongin-C

C: von Hippel-Lindau disease tumor suppressor

D: Bromodomain-containing protein 4

ヘテロ分子

概要:

• 登録者が定義した集合体
• 根拠: gel filtration
• 58.7 kDa, 4 ポリマー

構成要素の詳細:

	分子量 (理論値)	分子数
合計 (水以外)	58,743	5
ポリマ－	57,803	4
非ポリマー	940	1
水	0

対称操作:

タイプ	名称	対称操作	数
identity operation	1_555	x,y,z	1

2

E: Elongin-B

F: Elongin-C

G: von Hippel-Lindau disease tumor suppressor

H: Bromodomain-containing protein 4

ヘテロ分子

概要:

• 登録者が定義した集合体
• 58.7 kDa, 4 ポリマー

構成要素の詳細:

	分子量 (理論値)	分子数
合計 (水以外)	58,743	5
ポリマ－	57,803	4
非ポリマー	940	1
水	0

対称操作:

タイプ	名称	対称操作	数
identity operation	1_555	x,y,z	1

3

I: Elongin-B

J: Elongin-C

K: von Hippel-Lindau disease tumor suppressor

L: Bromodomain-containing protein 4

ヘテロ分子

概要:

• 登録者が定義した集合体
• 58.7 kDa, 4 ポリマー

構成要素の詳細:

	分子量 (理論値)	分子数
合計 (水以外)	58,743	5
ポリマ－	57,803	4
非ポリマー	940	1
水	0

対称操作:

タイプ	名称	対称操作	数
identity operation	1_555	x,y,z	1

4

M: Elongin-B

N: Elongin-C

O: von Hippel-Lindau disease tumor suppressor

P: Bromodomain-containing protein 4

ヘテロ分子

概要:

• 登録者が定義した集合体
• 58.7 kDa, 4 ポリマー

構成要素の詳細:

	分子量 (理論値)	分子数
合計 (水以外)	58,743	5
ポリマ－	57,803	4
非ポリマー	940	1
水	0

対称操作:

タイプ	名称	対称操作	数
identity operation	1_555	x,y,z	1

5

Q: Elongin-B

R: Elongin-C

S: von Hippel-Lindau disease tumor suppressor

T: Bromodomain-containing protein 4

ヘテロ分子

概要:

• 登録者が定義した集合体
• 58.7 kDa, 4 ポリマー

構成要素の詳細:

	分子量 (理論値)	分子数
合計 (水以外)	58,743	5
ポリマ－	57,803	4
非ポリマー	940	1
水	0

対称操作:

タイプ	名称	対称操作	数
identity operation	1_555	x,y,z	1

6

U: Elongin-B

V: Elongin-C

W: von Hippel-Lindau disease tumor suppressor

X: Bromodomain-containing protein 4

ヘテロ分子

概要:

• 登録者が定義した集合体
• 58.7 kDa, 4 ポリマー

構成要素の詳細:

	分子量 (理論値)	分子数
合計 (水以外)	58,743	5
ポリマ－	57,803	4
非ポリマー	940	1
水	0

対称操作:

タイプ	名称	対称操作	数
identity operation	1_555	x,y,z	1

単位格子

Length a, b, c (Å)	110.485, 164.048, 256.202
Angle α, β, γ (deg.)	90.000, 90.000, 90.000
Int Tables number	19
Space group name H-M	P212121
Space group name Hall	P2ac2ab
Symmetry operation	#1: x,y,z #2: x+1/2,-y+1/2,-z #3: -x,y+1/2,-z+1/2 #4: -x+1/2,-y,z+1/2

要素

#1: タンパク質

A E I M Q U
Elongin-B / EloB / Elongin 18 kDa subunit / RNA polymerase II transcription factor SIII subunit B / SIII p18 / Transcription elongation factor B polypeptide 2

詳細:

分子量: 13147.781 Da / 分子数: 6 / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 遺伝子: ELOB, TCEB2 / 発現宿主: Escherichia coli (大腸菌) / 参照: UniProt: Q15370

#2: タンパク質

B F J N R V
Elongin-C / EloC / Elongin 15 kDa subunit / RNA polymerase II transcription factor SIII subunit C / SIII p15 / Transcription elongation factor B polypeptide 1

詳細:

分子量: 10843.420 Da / 分子数: 6 / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 遺伝子: ELOC, TCEB1 / 発現宿主: Escherichia coli (大腸菌) / 参照: UniProt: Q15369

#3: タンパク質

C G K O S W
von Hippel-Lindau disease tumor suppressor / Protein G7 / pVHL

詳細:

分子量: 18712.328 Da / 分子数: 6 / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 遺伝子: VHL / 発現宿主: Escherichia coli (大腸菌) / 参照: UniProt: P40337

#4: タンパク質

D H L P T X
Bromodomain-containing protein 4 / Protein HUNK1

詳細:

分子量: 15099.380 Da / 分子数: 6 / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 遺伝子: BRD4, HUNK1 / 発現宿主: Escherichia coli (大腸菌) / 参照: UniProt: O60885

#5: 化合物

C-501 G-501 K-501 O-501 S-501 W-501
ChemComp-X5K / N-{3-[1-(4-{[3-(cyclopropylamino)-3-oxopropyl](methyl)amino}-6-{methyl[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]amino}-1,3,5-triazin-2-yl)piperidin-4-yl]propanoyl}-3-methyl-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide

詳細:

分子量: 940.211 Da / 分子数: 6 / 由来タイプ: 合成 / 式: C₄₈H₆₉N₁₃O₅S / タイプ: SUBJECT OF INVESTIGATION

• 研究の焦点であるリガンドがあるか: Y

実験情報

実験

• 実験: 手法: X線回折 / 使用した結晶の数: 1

試料調製

• 結晶: マシュー密度: 3.35 ų/Da / 溶媒含有率: 63.25 %
• 結晶化: 温度: 300 K / 手法: 蒸気拡散法 / 詳細: 0.2 M NA2MALON, 20 %W/V PEG 3350

データ収集

• 回折: 平均測定温度: 100 K / Serial crystal experiment: N
• 放射光源: 由来: シンクロトロン / サイト: ALS / ビームライン: 5.0.2 / 波長: 0.97903 Å
• 検出器: タイプ: DECTRIS PILATUS 2M / 検出器: PIXEL / 日付: 2020年6月4日
• 放射: モノクロメーター: M / プロトコル: SINGLE WAVELENGTH / 単色(M)・ラウエ(L): M / 散乱光タイプ: x-ray
• 放射波長: 波長: 0.97903 Å / 相対比: 1
• 反射: 解像度: 3.4→49.01 Å / Num. obs: 64886 / % possible obs: 100 % / 冗長度: 25 % / B_iso Wilson estimate: 76.05 Ų / CC_1/2: 0.992 / R_merge(I) obs: 0.772 / R_pim(I) all: 0.155 / R_rim(I) all: 0.788 / Χ²: 1.02 / Net I/σ(I): 5.3
• 反射 シェル: 解像度: 3.4→3.48 Å / 冗長度: 24.4 % / R_merge(I) obs: 3.442 / Num. unique obs: 4531 / CC_1/2: 0.343 / R_pim(I) all: 0.71 / R_rim(I) all: 1.3 / Χ²: 1.09 / % possible all: 100

解析

ソフトウェア

名称	バージョン	分類
PHENIX	1.18.2_3874+SVN	精密化
PHENIX	1.18.2_3874+SVN	精密化
XDS		データ削減
pointless		データスケーリング
AMoRE		位相決定

精密化

構造決定の手法: 分子置換
開始モデル: 4W91

4w91

解像度: 3.4→49.01 Å / SU ML: 0.7018 / 交差検証法: FREE R-VALUE / σ(F): 1.34 / 位相誤差: 38.7978
立体化学のターゲット値: GeoStd + Monomer Library + CDL v1.2

	Rfactor	反射数	%反射
Rfree	0.3242	3221	4.99 %
Rwork	0.2804	61388	-
obs	0.2826	64609	99.69 %

• 溶媒の処理: 減衰半径: 0.9 Å / VDWプローブ半径: 1.11 Å / 溶媒モデル: FLAT BULK SOLVENT MODEL
• 原子変位パラメータ: B_iso mean: 90.64 Ų

精密化ステップ

サイクル: LAST / 解像度: 3.4→49.01 Å

	タンパク質	核酸	リガンド	溶媒	全体
原子数	21721	0	402	0	22123

拘束条件

Refine-ID	タイプ	Dev ideal	数
X-RAY DIFFRACTION	f_bond_d	0.0077	22673
X-RAY DIFFRACTION	f_angle_d	1.5413	30832
X-RAY DIFFRACTION	f_chiral_restr	0.0889	3400
X-RAY DIFFRACTION	f_plane_restr	0.0107	4143
X-RAY DIFFRACTION	f_dihedral_angle_d	10.5367	3278

LS精密化 シェル

解像度 (Å)	Rfactor Rfree	Num. reflection Rfree	Rfactor Rwork	Num. reflection Rwork	Refine-ID	% reflection obs (%)
3.4-3.45	0.4644	145	0.4053	2667	X-RAY DIFFRACTION	99.86
3.45-3.5	0.4029	130	0.3829	2600	X-RAY DIFFRACTION	100
3.5-3.56	0.377	153	0.367	2654	X-RAY DIFFRACTION	99.89
3.56-3.62	0.3997	149	0.3683	2617	X-RAY DIFFRACTION	99.75
3.62-3.69	0.4456	147	0.4153	2624	X-RAY DIFFRACTION	99.89
3.69-3.76	0.4314	112	0.3642	2675	X-RAY DIFFRACTION	99.93
3.76-3.84	0.3529	134	0.3315	2638	X-RAY DIFFRACTION	99.86
3.84-3.92	0.418	124	0.3322	2660	X-RAY DIFFRACTION	99.78
3.92-4.01	0.3723	157	0.3401	2617	X-RAY DIFFRACTION	99.71
4.01-4.11	0.3151	135	0.3068	2667	X-RAY DIFFRACTION	99.75
4.11-4.22	0.3269	144	0.2889	2658	X-RAY DIFFRACTION	99.61
4.22-4.35	0.3159	122	0.2622	2634	X-RAY DIFFRACTION	99.6
4.35-4.49	0.3205	145	0.2576	2657	X-RAY DIFFRACTION	99.68
4.49-4.65	0.3075	159	0.2556	2638	X-RAY DIFFRACTION	99.71
4.65-4.83	0.3238	138	0.2608	2698	X-RAY DIFFRACTION	99.79
4.83-5.05	0.2747	118	0.2532	2653	X-RAY DIFFRACTION	99.57
5.05-5.32	0.3523	142	0.2614	2659	X-RAY DIFFRACTION	99.75
5.32-5.65	0.3332	141	0.2617	2692	X-RAY DIFFRACTION	99.79
5.65-6.09	0.2951	134	0.2691	2692	X-RAY DIFFRACTION	99.72
6.09-6.7	0.2592	135	0.2615	2692	X-RAY DIFFRACTION	99.65
6.7-7.67	0.2955	163	0.2407	2710	X-RAY DIFFRACTION	99.93
7.67-9.64	0.2339	154	0.2053	2747	X-RAY DIFFRACTION	99.72
9.65-49.01	0.2648	140	0.2072	2839	X-RAY DIFFRACTION	98.09

精密化 TLS

手法: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°2)	L12 (°2)	L13 (°2)	L22 (°2)	L23 (°2)	L33 (°2)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å2)	T12 (Å2)	T13 (Å2)	T22 (Å2)	T23 (Å2)	T33 (Å2)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	-0.00165400789773	-0.00756254732941	0.0056410122765	0.0315077767236	-0.0327686896148	0.0295086216377	0.220778429759	0.234377986003	-0.363891222363	-0.280930054443	0.172551319349	0.718441789909	0.0287098352754	-0.117839167076	0.000595245628202	0.833789611878	-0.105435077941	-0.118634694438	0.753782629555	-0.0961116736136	1.10615727205	-34.5347064139	31.1040071716	-46.2114467081
2	0.310316085207	0.0620740181244	-0.0101184836046	0.494021652598	-0.189714585319	0.512314923366	-0.206524330548	0.0175074120866	-0.115543556499	-0.0413499271729	-0.212039267105	0.0934640428442	0.0314006996928	-0.0493449548916	-0.252517755303	0.882052114556	0.2156025883	-0.194233569242	0.115506551473	-0.262563573448	0.627927077348	-32.751509688	30.6905095275	-40.8864334798
3	-0.0103589424675	-0.00298231962565	0.00126337890404	0.0102845728911	-0.00947861655545	0.00799804628635	-0.0487029628175	-0.370284098355	0.255472876373	0.0678075512353	-0.284508823403	0.318300466089	-0.121886973171	0.0936984141735	8.02665585345E-5	0.868566817141	0.114911226516	-0.0581746958171	0.876180944678	-0.0178128269824	1.00902638083	-40.4991691529	39.5429823908	-38.5504367742
4	0.00471150764775	0.00470510444363	-0.00287426403071	-0.00171609836967	0.0020416350143	0.00343419730646	-0.110640206176	0.0238373164731	0.127605185635	-0.121783604698	-0.0893580930595	-0.185752034057	-0.00620183944486	0.0326546749388	-0.000224620245274	0.672319371188	-0.2191753898	-0.111455024493	0.500799065031	-0.12606465242	1.13395469794	-29.7126919237	43.9905382782	-46.2359567356
5	0.00954108506419	0.00432837945545	0.0012237416935	0.00289304132861	0.00175873072456	-0.00270896812073	0.0628772113897	-0.0578310319925	0.0969986603616	-0.0592601384638	0.021053968097	0.0644443670168	-0.0112853853603	0.0265395669636	-7.6866722571E-5	0.916129996051	0.113731178061	-0.187963013948	0.7799240897	0.0562244074458	0.72767604584	-38.1159627385	39.9418061757	-52.625071414
6	0.00319486383013	-0.00117207938986	0.00200910805763	0.00277967810085	-8.89389645025E-5	0.0010672860654	-0.041822192599	-0.0172147653404	0.00375882849791	-0.000581184540242	0.0154715722557	0.0566408952246	0.00480528775453	-0.0570922511159	8.35922563746E-5	1.12189828766	-0.292724364226	-0.0681769060768	1.18003104072	0.0908948362272	1.02948472046	-32.0212406106	26.0872296819	-53.3043069133
7	0.0113917515274	-0.000858700142847	-0.0210861224996	0.00795235049413	0.016064715808	0.0666392875897	0.0496487937702	-0.0238827667198	0.183236792745	0.0251284410999	0.0846110658171	0.0821478451274	-0.0232275009857	-0.0135500694546	0.0129707589414	0.98377573883	0.54650920821	-0.174995937262	0.478252233996	-0.105118238283	0.921134627537	-30.0520422772	37.3727160333	-43.7623689905
8	0.00205827985857	-0.00230310344916	-0.0013965657289	0.00111279857515	0.00287464670694	0.00104210571515	-0.0325888482692	0.0126512881683	0.0560475405146	0.122539105747	-0.0309947264953	-0.0393763778521	-0.0697760601838	-0.00572174372314	-0.000152425238541	1.71806281537	-0.470636887013	-0.329440536504	1.52167604732	0.163351005253	1.40964002507	-28.5474238237	48.0438471362	-33.2798381153
9	0.0151566323729	-0.0166211114938	-1.91316629869E-6	0.028215129448	-0.000456712689532	0.000165002501694	0.0931357176044	0.0092835351815	-0.0385792604105	0.106977725753	0.05712187465	0.0469021133469	0.0524375354687	-0.0727124166925	0.000131189174779	0.954323345717	0.0934677230132	0.0993521518163	0.949255795336	-0.0692239849821	0.844846838813	-19.4096530401	34.0698174145	-40.201922652
10	0.113799920255	0.0352404543481	-0.136503851007	0.0125811614328	-0.0453106458299	0.164614971591	-0.122769995889	0.189742489494	-0.316494135849	-0.00052300729852	-0.114976770066	-0.203388881446	0.195342815226	0.208064199716	-0.0140996808822	1.05853651875	-0.102416546822	-0.155367539002	1.04040125267	0.236041763444	1.00996774061	-9.32041502959	18.2390936284	-49.4748380552
11	0.451606615529	0.0732451049528	-0.239789199448	0.203570100047	-0.259646108855	0.376134374079	-0.0698375432193	0.10553744023	-0.0119045203221	0.0171587505726	-0.410583962362	0.362969204021	-0.141509745171	0.230187154099	-0.29855330965	0.343401093612	-0.270450803974	-0.259374149325	0.660867918391	-0.0453050239996	0.612909054449	-28.3870736605	24.6554109634	-33.7972417218
12	0.238608655342	0.12934389626	0.159126517746	0.0902641170843	0.110349335815	0.114981863285	-0.0610915273557	-0.130685208557	0.151257242387	-0.162241843992	-0.220066339558	0.10406690396	-0.0343598497858	-0.0243342811719	-0.426731873668	0.0533886249553	-0.0625389080617	0.120539354546	0.335603488316	-0.172855584911	0.599920099342	-33.9423704792	17.4436797539	-35.7229056834
13	0.012541113378	-0.00532921347912	-0.00401078863871	0.00308919825405	0.00187950528484	0.000956463785628	-0.0553901340481	-0.184669261788	-0.0832293209306	0.0383196883765	0.0689297632456	0.171464777628	0.0184826713055	-0.0686544668714	0.000121461406575	0.823035930217	0.187012260916	0.0631228088752	0.394647946555	0.251028948738	0.42590963413	-36.976681412	13.3971259498	-25.5834799453
14	0.126500660857	0.0624805420926	0.0160046548056	0.0411509040777	0.0297251970852	0.0749072467658	-0.0336152782266	-0.0726168022956	0.127704720142	0.0761548087676	-0.102763146546	-0.00295976574932	0.0288607641957	-0.0931207403175	-0.065514589498	0.139351542714	-0.269825521998	0.042154538396	0.435811425806	-0.251526560789	0.704106505286	-22.6694029534	19.1602686597	-31.6905677408
15	0.0639650071626	0.023048276362	0.0284561088384	0.0186451469393	0.0281061536786	0.0260185734102	-0.0209527317772	0.0304238907634	-0.0235291936586	-0.0825483851797	-0.0917349167604	0.242208083455	0.0170574178957	-0.0854511517438	-0.0371332168456	0.181125143342	-0.0294142571095	-0.0511414773504	0.284218024746	-0.0810041663438	0.365197929037	-29.7056850843	19.566876879	-45.176471368
16	-0.000494617488368	0.00269311856056	0.00762116728026	-4.72620242538E-5	0.000342272603605	0.00220795269392	-0.0849809347871	0.0545640724416	-0.0806273815071	-0.113296319303	-0.480684139168	0.0961349464137	0.13499580441	-0.185504639481	-0.0206526871498	0.393885303754	-0.157762969203	0.0174633754997	0.501414889469	-0.0312785899787	0.728950071835	-34.8132453383	16.0147757193	-55.0034102024
17	0.41517995836	-0.369234565644	-0.172330980196	0.382914966678	0.318868790502	0.577815044876	-0.354027813859	-0.0278390222178	0.0999595060041	0.181659874525	-0.0869751261328	0.00272510548603	0.0461040313847	0.121985960995	-0.201484313245	0.193869861788	0.0811806368758	0.00422085162025	0.657822718494	-0.0607295346342	0.382096628072	-20.72363469	12.9886941355	-43.5923227107
18	0.436775953506	-0.0326066144609	-0.212116087825	0.192769938892	0.117661475921	0.193717461004	-0.0584648803714	-0.355961810078	-0.16912460437	0.141453273489	0.0175174284485	0.00599474267321	0.0441306887509	0.196741416514	-0.0287725322027	0.558936360919	0.313879852546	-0.028395525158	0.987369143199	-0.139655521618	0.692749706025	-44.1864471179	-14.1443822718	-66.9828781263
19	0.16878966298	-0.134182183542	0.176615316087	0.2749748649	-0.199797799985	0.181082561566	-0.114669511562	0.264102490261	-0.119940679685	0.0937802396378	-0.239093703212	-0.0515422915915	-0.05374302778	-0.280769787558	-0.423525865565	0.458276272674	-0.125011049746	0.117764301867	0.663642008347	-0.14135260006	0.331825334174	-39.0057479474	6.73401042913	-69.3802962543
20	0.122611406933	-0.0175878474057	0.0294466122933	0.019184595765	0.0510648370604	0.189759836453	-0.00830678464295	0.0132342712684	0.0803038636133	0.0435207425551	-0.0205672111364	-0.00837114556946	0.237745243525	0.122647766089	0.125019966438	0.274147823276	0.561271091839	0.097120952904	0.651234156732	-0.190279649825	0.283872512474	-34.9922539642	-8.07932588602	-67.3777802524
21	0.0502799173559	0.0487541503197	-0.0361607032111	0.0550456228874	-0.0421182606686	0.0552244866929	0.0807879999353	0.125209576391	0.104081158376	-0.00853035554027	0.0290869908428	0.0493923957376	0.0260412097443	0.470176640074	0.159958349965	0.568650328821	-0.0626022230908	0.191157689484	0.968205269257	-0.156345933024	0.418618111759	-38.1830982349	0.0908532023381	-72.8921367814
22	-0.00184788067024	0.0153027103188	0.00719374081958	0.0639434039194	0.0564462018363	0.0529721234318	0.109162004658	-0.0840121768767	-0.0144652239047	-0.0807653342357	0.157821984516	-0.14453075651	-0.100623340599	0.109568657504	0.307727743662	0.306055758226	0.426471622933	0.445488460586	0.409945313116	-0.42511258963	-0.502485206028	-33.2225422337	2.01157661284	-62.5799266749
23	0.0298645322667	-0.0428884321819	0.00652881823361	0.0741346083315	0.0194053308442	0.0276559327678	0.00970834140685	-0.00337851511652	0.247259311203	-0.0514737231247	0.110421277258	-0.206799643732	0.184309840542	0.0742942194553	0.0241582755089	0.364593906027	-0.168519467006	0.00775442140662	0.607350452673	-0.00794314714793	0.368602144213	-45.8337911001	-0.205619043542	-63.1068051188
24	0.198588168598	-0.0920258690915	0.00190229176171	0.128154488492	-0.0416571143466	0.0210232322372	0.0941267353029	-0.247360379667	0.238138468446	0.0562059891223	0.355039204999	-0.213789348427	-0.162845620844	0.134370566851	0.533461395434	0.198920156928	0.303755359929	0.257332122645	1.07847288376	-0.332728891091	-0.0239813191616	-43.1860373795	6.76461969888	-64.2335978035
25	0.0310637885988	0.030496991379	0.0102257376504	0.00593637396138	0.041277100211	0.216715219048	-0.0950486538439	-0.0370107972001	-0.163744390258	-0.0751289488449	0.211970115202	-0.240536032783	-0.0432592571401	-0.0103986062289	0.225835893285	-0.472344325375	0.0276313400781	0.369137945091	0.700601314961	-0.242339590838	0.373366172273	-15.5701860707	6.26504910055	-50.6876322017
26	0.0165609875661	0.00137323603909	-0.0189217891113	0.0132837214037	0.00422195711738	0.0206983144662	0.263099933454	0.0515744977967	-0.122928495569	-0.0583371854134	-0.0366815961323	0.269365939953	-0.0713672245879	0.00927172855782	0.000146471571585	0.819295714907	0.103509030765	0.000515563828704	1.01400963557	-0.177368390768	0.592348702533	-19.116598448	-0.488828565943	-51.1950543605
27	0.0146534199454	-0.0193301728408	-0.0120503913313	0.0306119285875	0.0177473983559	0.0077987539506	-0.145354437238	-0.0162098289226	-0.346985426787	-0.0940913069967	-0.260739276849	0.248655250219	-0.0568692606824	0.0630282451026	-0.000498491947211	0.686570227676	0.212418152337	0.111312653283	0.836901094011	-0.0511076085878	0.990120940495	-35.220616397	-7.94703131816	-53.4096300534
28	0.0107239077668	0.0829546942411	-0.115630951126	0.280156267591	-0.407100119532	0.566940232061	-0.212854342335	-0.108339219607	-0.56726519769	-0.142608254885	-0.0235890990023	0.06289152994	0.318628368762	0.23615871013	-0.0031890484099	1.54266258829	0.182823933862	0.225827627883	0.403001927339	-0.0898682314317	1.06718100454	-31.3113049251	-27.1501601266	-77.8855666549
29	-0.00198081294962	-0.000757772163409	-0.0189252376648	0.0326188855439	-0.0138403654977	0.0207625268576	-0.134383153412	-0.245105735552	0.0200107409937	-0.118046399709	0.167898222116	0.295988812623	0.496291595172	0.113690192129	-4.69892992385E-5	1.93838709896	-0.415884177257	0.145622536344	0.998493412984	-0.286030095896	1.237735951	-40.2803926514	-30.3742236793	-86.8881601134
30	0.158944166217	0.0542291568652	0.0885691938072	0.0353408530295	0.0562520795292	0.0923615501495	0.172924651234	-0.0524336282912	-0.0374264441848	0.0355073698475	-0.0148371484065	0.0606482588975	0.0360404490784	-0.0661766868831	0.257415445984	1.47667321572	-0.00784901840838	0.117810874854	0.731137664119	-0.641536343228	0.11822216438	-34.592864792	-23.9119738481	-89.7992539912
31	0.0178217545497	0.0258349768802	0.0526817775008	0.236185953052	0.0121551711134	0.433927715658	0.206983016987	-0.082428520562	0.114037953224	0.076334458958	0.0635601562001	0.242000542965	0.184056576422	0.234050548979	0.185276785352	0.809839237763	-0.0408442814041	0.0592248065175	0.1008125505	-0.0745455399438	0.399424404108	-28.1540034793	-19.4738486217	-84.4550361577
32	0.164923421475	0.13840519656	0.174507224594	0.12765292656	0.145908280095	0.185977740797	0.13875117386	0.0377584160323	-0.0499249134484	0.100878806116	0.100268369449	0.135657131692	0.00473970801033	0.0483029722409	0.330027731732	0.927413949225	0.381819350892	0.0682871362074	0.456920209793	-0.226613614316	1.03890528328	-89.9171465788	-30.0530759415	-105.857410587
33	0.0453656715742	-0.0219622422491	-0.0490921332111	0.0929838496423	0.0429983543519	0.0591884948075	0.0835840498634	-0.115794297572	-0.0100717312399	0.145729524151	-0.00555561879358	-0.0917361783512	-0.117017602808	0.0819191667511	0.0604274157534	0.794363050511	-0.48607037167	-0.321514710203	0.193474603134	-0.395066001623	0.912445896013	-91.5437779818	-31.0481819249	-109.03172221
34	0.00877837416024	0.0273549313796	-0.0473180036138	0.0546851291077	-0.0995821666549	0.188648458577	-0.078694589201	-0.0119834993895	0.0913203420934	-0.0565786317514	-0.0930049368364	0.00924572399955	-0.0369096945637	-0.146227439796	-0.153706612509	0.283703750415	-0.0104258896766	-0.431756511391	0.160057037917	-0.885337729298	0.985016642343	-97.1009681207	-35.9273455583	-114.777668081
35	0.00505985162573	-0.00990649741396	0.0230192849379	0.0169742307094	-0.0301555893525	0.134502149429	-0.095230283625	0.069746553943	-0.171849287975	0.17731409113	0.0183894053837	-0.104896532468	0.0862653998026	0.00939397871262	-0.0420976566569	0.7347568328	-0.118582815278	0.161039122155	0.292457566953	-0.142000011998	1.45300373922	-91.7408066515	-41.8248317766	-115.218197506
36	0.0501629316738	0.0163065991736	-0.0143341752718	0.00555868331625	-0.00305466281586	0.0323314187286	0.0151068475029	0.00484818790083	-0.120522489666	0.160970203739	-0.139032638202	-0.188086482567	-0.0295205399498	0.0167953029613	-0.0115231425475	1.07553750361	0.0122866229528	-0.0112003326706	0.439778380784	-0.178017237775	1.95032210941	-92.5804827231	-42.7933191448	-102.964439381
37	0.00507434507835	0.000674361432854	-0.00860519335775	0.0113838722927	0.00332673299987	0.0489392780498	-0.0102897945736	0.075186885639	0.223327466877	0.0132475151364	0.0101014164872	-0.0419750928528	0.100273303754	0.0188203032045	-0.00459359700501	0.63169632784	0.448172657333	-0.118466325473	0.369413548883	0.264643548294	0.550843487787	-89.2921646106	-28.2230257911	-97.6552456816
38	0.0415585863451	0.113924967365	-0.0897248340571	0.252893318037	-0.201712750439	0.162928463535	0.0728078111027	0.0993939665263	-0.0970255697161	-0.0992462219159	0.0096142494093	0.0512094622808	0.130667718054	0.070806826355	0.20756290851	0.653247948578	0.26612749741	0.109180779079	0.0944863638527	-0.197815953532	0.803649855954	-86.2943158864	-39.4480609255	-113.196870059
39	0.0102113781089	-0.00136257518404	0.0249192933863	-0.00116566159813	-0.00284991729747	0.0616205970659	-0.0151527496845	0.00770106864316	-0.0199451133558	-0.0573337119397	-0.108473709252	-0.0209937122801	-0.0389488780273	0.00680386094116	-0.000705663524098	1.61056700069	-0.109371941642	0.0200958789993	1.95688775265	-0.908563424248	1.43319793748	-87.9690420906	-49.7555415187	-120.558253677
40	0.0154740475708	0.0204686817292	0.0218689767297	0.0252971226626	0.0312555175248	0.0406315971235	0.0618342734554	-0.00673854394109	0.0747688567464	-0.0763595510333	0.0265525039494	-0.00172505079855	0.0328528926716	0.0457537869794	0.000260229004976	0.942091367832	0.160562379673	0.266478521626	1.22550729905	-0.458131344288	1.53651356722	-79.7214018794	-41.6045446185	-113.978854828
41	0.0647370018919	-0.0156057051295	-0.00199632865573	0.00411396100598	0.000317542684489	-0.000848470256436	-0.039804605408	0.0221970996833	-0.0540057771467	-0.0397870494071	-0.0525804100333	-0.142602980393	0.0154510097069	0.0314332699241	-0.0103630851706	0.61038152282	0.549216821126	-0.0350335191152	0.776343725582	-0.105754602783	1.11816048944	-73.240699484	-29.1937274848	-110.940079339
42	0.0272036631231	-0.0304891016482	0.0229407002127	0.0312916388397	0.00302225216991	0.153447191401	-0.0814233665174	0.00647076097738	0.141979603625	-0.0128667858674	-0.0890279324296	-0.0984366921022	-0.0597682652199	0.150141383983	-0.0157388803817	0.213885779252	-0.100645591693	-0.0178552319526	0.723052122779	-0.162009111372	0.921510683102	-63.575227553	-17.406036683	-101.386621578
43	0.505123773397	-0.215937989762	-0.439182587022	0.120342708666	0.252251513807	0.565921669079	-0.35746797629	0.123508022962	0.0329264132529	0.0386377563045	-0.0572692971296	0.376347823941	0.0266781516377	-0.100057371547	-0.453637432656	0.144250714683	0.0704977038869	-0.0655026389323	0.204702019013	-0.269116593744	0.552038153311	-86.7378264495	-19.0648944301	-117.022265854
44	0.0240186324259	-0.00221615956085	0.0153336053088	0.03862431774	0.00606460446182	0.00587959330086	-0.0177370723175	0.0313836739918	0.0238409190946	-0.0259288466989	0.00688089282791	0.0420753800476	-0.000236564031255	-0.0389555238733	0.100696662323	0.493197270761	-0.495906253211	-0.364890042168	0.130048588259	-0.232233671475	0.161977407526	-91.6577080941	-12.8841927215	-125.959904944
45	0.0978107139176	-0.0612016363454	0.124923783722	0.0362551653211	-0.0849665500806	0.395407556611	-0.220229819152	-0.0929644565796	-0.141087972688	-0.0842846042184	-0.19793214765	0.107097237104	0.0567165750011	-0.0100276171951	-0.160871885598	0.50110484162	0.337508095698	-0.221034545817	0.62805647554	-0.274534677469	0.572061456215	-77.5702442623	-18.32592617	-120.411549428
46	0.0389732691401	-0.0604269427663	-0.0342958159254	0.139130946319	0.0742810753868	0.117486827978	0.061868379009	0.00992777482278	-0.20430467866	-0.287902395071	0.0468495598622	-0.176653938235	-0.0848727571765	-0.210836525146	0.399581389562	0.416193228681	0.329242858998	-0.0409981066639	-0.433299905375	-0.0171487991636	0.2866239666	-85.4790149577	-18.4949510344	-106.068177872
47	0.0513049144435	0.0430822360429	0.00140391728634	0.0450608753066	-0.0277605763562	0.0507975534042	0.110892348658	0.0432357535266	-0.0154900572687	0.10455288643	0.0471527116466	-0.0723682116951	-0.0533538837456	0.0627695205256	0.0582811396613	0.355256242642	0.216996404164	-0.219051291402	0.0658275227489	-0.117391702819	0.473382017122	-89.5729791652	-15.0614132858	-96.7350895004
48	0.321453521948	0.122725992951	-0.11082841245	0.0639558595262	-0.0671371056252	0.0890861164305	-0.363890321611	-0.18172088938	-0.151797568151	0.0263892131093	0.0509431070481	0.262484043422	-0.00776712689074	0.167788594875	-0.149622794176	0.413314407725	0.317418103957	-0.155637028014	0.41738391339	-0.453968090919	0.632619128184	-75.654940946	-12.4869698204	-108.103781639
49	0.140049429558	-0.0247754285304	-0.00266105713229	0.0138065011716	-0.0320766215358	0.0839249174876	-0.211150220915	0.112845561297	0.133875167598	0.00278502908462	-0.0882139587437	-0.0598547717084	-0.0408917062884	0.123510622394	-0.143773081114	0.524591892482	-0.30716221221	-0.294435282624	0.0883874219	0.318647591368	0.768903646847	-98.2169599545	14.5824387029	-84.0943443463
50	0.452038659953	-0.14359076331	-0.0617579726662	0.271452782158	-0.00372449259112	0.174775582045	0.0967304008688	-0.250489547542	0.423325969063	-0.187002088298	0.132961559143	-0.0260574117112	0.243598281797	0.193256469916	0.943996123892	0.491385979579	0.169354302401	-0.303488686307	0.136185352056	0.0766863743965	0.284426927357	-90.033830561	-0.347602456792	-82.0858916558
51	0.351658621937	-0.0554930829496	0.214297784293	0.309545835187	0.149528726726	0.495095433374	0.183966516635	-0.0944787707308	-0.139265135044	0.149919652656	0.0251847793492	0.0733975355261	0.367785852969	-0.0436054460334	0.749497642708	-0.264525520468	-0.268892756543	-0.853362971617	-0.0810203051317	-0.249867077122	-0.666214090545	-96.6568203775	3.15318226083	-79.577100333
52	0.224988469409	-0.0872158090145	0.060191761724	0.143278423702	-0.0671642735373	0.0735506465528	-0.10155405531	0.0433986587838	0.0536789561203	-0.0831061123877	-0.109483844916	-0.0859990576583	-0.0803658442508	0.0986040039913	-0.367559210773	0.527254901757	-0.371221086023	-0.363351186106	0.235845275505	-0.328655481951	0.154080881579	-83.4937640311	-3.01974085402	-89.4433662499
53	0.161605368788	-0.202809298231	-0.145687341771	0.270944321436	0.173081339907	0.117540336782	-0.0134780320661	-0.0130545905244	0.142516094626	-0.00337402796126	0.0248852260326	-0.0954373881852	0.0285258000563	-0.0501750914496	0.274487387275	0.131341771648	-0.540875085599	-0.109626310388	-0.212734912524	0.301852729474	0.242509066521	-96.255718413	-1.51455359684	-91.4603647387
54	0.0169954514777	-0.0270754919048	0.0166911038344	0.0412776066096	-0.0240611660142	0.0128558015487	0.0488761854807	0.0373633998573	0.0515098859828	-0.0118372258381	-0.0243184906691	0.107441612287	-0.0592440519717	-0.111218035096	0.0120767621236	0.415692664708	0.212005153842	-0.194719310693	0.00956461841083	0.298501832695	0.576172060511	-108.245601609	1.03490377124	-79.6809727222
55	0.0224867380416	0.05370731102	0.0938787798195	0.608423713508	0.314348505418	0.291137291845	0.0477210614051	-0.198220335067	-0.184788649836	-0.0923416601228	0.34878096016	-0.112899258003	-0.035482959718	-0.00967667776021	0.53220995273	0.0087330898612	-0.142294762803	-0.511651104939	-0.0614625863524	-0.695891334431	0.0116860880959	-84.02822403	-8.22171847529	-95.5814801124
56	0.00133934361063	0.00219640331904	0.0065919843178	0.0119937468595	-0.0037587421372	0.00724185467702	0.00793776470964	0.0812948245555	0.105148723876	0.147163285727	-0.0134368542265	-0.138731327785	-0.0390041367031	-0.0792786711337	0.000118908890454	0.358233507167	-0.179185875309	-0.159876926835	0.926807634825	-0.0148187472625	0.714031554507	-64.0986336053	-4.85984684076	-100.256692362
57	0.312008219627	0.0228708430783	0.061533876259	-0.000742372812726	0.00650216137006	0.0110128698729	-0.0444487754353	-0.152226268448	0.103854608993	-0.302937593559	-0.184493700976	-0.201721790225	0.100886712417	0.0404280509907	-0.0100204137111	0.883690194448	0.00620504246259	0.0790230164148	0.28372528522	0.0762206365122	0.642066162937	-74.0899303442	1.19939458737	-101.200975718
58	0.293111165326	0.235157008093	0.129411372409	0.555099616774	0.377986450174	0.263493641501	0.0400435934704	0.114594347018	0.508107816243	-0.0487640111748	0.0184453045361	0.42274905875	-0.119358156921	0.0169122219893	-0.0571355809186	1.0826101241	-0.163871818293	-0.0799772215894	0.354835779767	0.0677011298253	0.620157460625	-90.6693142805	8.89654468009	-98.8341364355
59	0.00165212778617	-0.00862255835522	-0.00509700513076	0.033649489204	0.0103714850578	0.0219077463293	-0.0337733190537	0.0103701372484	-0.136809215395	-0.0310840464784	-0.015247284558	0.0409749729273	0.0369369034357	-0.0559432169617	0.0145190619096	0.392572539775	-0.465499590056	-0.022952108281	1.07779774164	0.0629239127405	1.20644013866	-79.7430793073	36.6809979342	-69.497522926
60	-0.00265868541262	0.0116362289414	-0.00551039343612	0.0259521740664	-0.0231011938374	0.0111396218882	0.0447921833654	0.134728152499	-0.14753455704	-0.164849758045	0.131367234371	0.249701381635	0.185301249545	-0.0765917896352	0.000508959145498	0.73358521843	-0.114565010886	0.107861509639	0.99774021696	-0.196321706788	0.485425072931	-88.8675005211	23.839152066	-75.066779627
61	0.126347102333	-0.0789180978251	-0.0305126815709	0.115254816201	0.024407164061	0.00499461049014	-0.015697622481	0.0316953676093	0.0871125047112	-0.0495292291132	-0.00365857729142	0.140143079231	0.020327775957	-0.0129455061341	-0.0544528691603	0.12043557436	0.155131238284	-0.0531722435575	0.199785918734	-0.00496805854059	0.993470611853	-106.537692463	22.4312993636	-64.8681920466
62	0.178267161997	0.181857359045	-0.0952779463212	0.228821786872	-0.0600645040423	0.0758724349077	-0.155402267403	0.0678029512132	-0.208584120451	-0.0529093272411	0.0986814968312	-0.395705515848	0.189016776605	0.0606078328566	-0.0136113436783	-0.159860229562	-0.428201833048	0.148662591759	-0.478621908756	0.227010074863	0.292904238786	-91.7394914846	30.6262460572	-63.237175747
63	0.00373322211797	-0.00457159904055	0.0266707045523	0.0101713337094	-0.0159999515499	0.0600131481586	0.152678628799	0.0535058157889	0.0382771510291	-0.121348911809	0.0585294206458	0.0636261573012	-0.0856287857523	0.0654061228589	0.241295722107	0.129657117442	0.698994479477	0.270863334482	-0.328218322146	-0.607473114281	0.283690911205	-88.0205680647	16.771112513	-66.5785865855
64	0.00725793926649	0.00486681852957	-0.00868497096215	0.0112884000517	0.000504583952307	0.0030458588905	0.116632882773	0.0106431614005	0.125315303631	-0.00699669312415	0.0951965807411	-0.00459614321529	-0.283536389584	-0.0486623534728	0.000215059242708	1.30100762011	-0.186385128584	0.418719382578	0.739027544613	-0.168185129718	1.67046729853	-72.7700341396	33.7310030659	-64.987295478
65	0.0287798889078	-0.0203379038867	-0.0192290691633	0.0136811213292	0.00287263786679	0.0106815870308	0.203789466359	0.12516215341	0.211384100373	0.0510779706035	0.122609683263	-0.203977344665	0.00837113711697	0.0614318879258	-1.83398729744E-5	0.74473130719	-0.217612106369	-0.209375266419	1.51138055117	0.194957599768	1.24645826202	-27.0424790345	26.400044903	-90.9235138673
66	0.00905279602951	0.0145750507896	0.0108593878858	0.00707513301969	0.0046357459119	0.00168261552103	-0.112450876368	-0.117801374548	0.195995723264	-0.119890913194	0.0241905672223	-0.263412294379	0.0873824880465	0.168643743202	0.00012403266402	0.946052356144	-0.123698820533	0.0981497095527	1.98076069358	-0.40815284759	1.40678729599	-20.1215675931	33.318566714	-94.4270676775
67	0.0164396025926	-0.0275373332533	0.0158716963092	0.0276767252216	-0.0167382757208	0.0152219787235	-0.167194426184	0.0621812090787	-0.0702784157796	-0.327791494004	-0.314975464517	-0.436712220688	-0.0134945301195	0.21219897446	-0.000320009890968	1.59502896668	-0.567841316363	0.0495698877986	1.75701636441	-0.0101226413437	1.28451262086	-26.0718061373	28.1619919919	-81.2353596476
68	0.022873141948	0.026008171666	0.0019600116211	0.0190711734666	0.00102746032509	0.0150945746179	0.0776547730533	0.128598100583	0.135383230442	0.0206035287603	-0.0499261350954	-0.474625256709	0.113584416844	0.0160738534274	0.000467930650601	1.71839788876	-0.190029624281	0.0722547128788	1.71525349311	0.446211966194	1.60574407256	-21.4022544357	38.5168409026	-97.7164303654
69	0.0404374093147	0.0949866106167	0.0767982510475	0.277424034282	0.178543783876	0.173900908344	-0.225960042921	-0.166444199782	0.113081470549	-0.0825527732828	0.0803708486685	0.0816602319107	-0.19282981383	-0.28846589589	-0.179249377672	1.70264636835	-0.0520691036417	-0.218968819412	1.26234793366	0.175596038884	1.05875278264	-47.4430363941	44.330912756	-89.3353310586
70	0.0160691124366	0.00979435415835	-0.005169644897	0.00405474436465	-0.00631703145893	0.0159340144577	-0.0685879188391	0.0997820475911	0.300204127746	-0.00786396557873	0.0565857495057	0.0178645794913	-0.360676524548	-0.0984139669474	0.00014203459617	1.37034223246	-0.121112947764	-0.0910619745639	1.08255097332	-0.0529924804783	0.940484756391	-38.5346846086	30.2878531945	-100.869910047
71	0.0143869540476	-0.00461177757295	-0.0037898698159	0.00569278325255	0.008505104807	0.00702379125713	0.0571591525846	0.177149702344	0.259567467238	-0.0381296061798	-0.212924123998	0.0250250955683	-0.133363811865	0.131875374924	-5.14575154802E-5	1.31672378247	-0.108802951386	-0.102015337423	1.10153431001	-0.0815483176165	0.869868768774	-39.6734773471	22.9580841497	-96.9353683105
72	0.0290122029588	-0.0198184794893	0.0294013260891	0.014765188754	-0.0202344581116	0.0282152681024	0.0257999133259	0.0641993206782	0.00208292493288	-0.0673136707982	-0.00893234698371	0.0253529194848	0.0083904441527	-0.00821672231477	0.0121649552216	1.03974178898	-0.315880518791	-0.554876172158	0.955779764457	-0.407579539829	0.673757901359	-49.1470847032	22.0934993389	-101.816969406
73	0.205470648905	0.164742057933	0.0380427488377	0.126313279812	0.0303741600709	0.0118353338496	0.147087830102	0.0675349688582	-0.103405351073	-0.116325285221	0.0122119229023	0.115520001003	-0.0401326694584	0.0140330308659	0.000344538016046	1.38629962997	0.17381011443	-0.326991225475	1.82534705906	-0.0965187403922	0.996018483064	-44.3602962357	17.348703622	-109.401055334
74	0.509670335389	0.140788794027	-0.324665137237	0.0926639787391	-0.101208701843	0.193215680248	-0.430500964046	-0.170806650921	-0.262321677495	-0.384339974205	-0.144794251236	-0.043108545296	-0.16299555596	-0.0372031546064	-0.112982618541	1.01278041127	-0.382833042944	-0.275448259776	0.702534011006	0.0838423388973	0.468159847586	-44.2143587038	26.7140281709	-88.8987139594
75	0.0152406126012	-0.0176780752628	0.00994396013875	0.0182404974017	-0.0114899015653	0.00495758006787	0.0225377796649	-0.115962597822	0.140046906935	0.00239746095231	0.0961524309328	-0.0648889764822	0.0386003237428	-0.143801141741	-0.000131161448971	1.12363053792	0.0795578344108	-0.430326423162	0.77293960668	-0.102217388196	1.2083901708	-52.8883057692	32.9919122479	-91.3313548603
76	0.610923079556	0.367490487221	-0.170437407959	0.259639444805	0.0854251242349	0.436527821878	-0.189239400839	-0.129630387141	-0.300225216972	0.013972690786	-0.166997912674	-0.00591559019233	-0.118960525528	-0.186723223516	-0.864185099064	0.106542607512	-0.0399218203623	0.0470944846146	0.324529695131	-0.181355296519	0.457993966284	-57.6820130565	12.7857471927	-65.947033764
77	1.66066503513	0.152214801986	-0.717659580193	0.322664923933	-0.130964653391	0.340352656382	-0.363094565979	-0.209622622823	0.301127806373	-0.304073285345	0.166742668893	-0.0494629137834	-0.394145320376	0.0333982385907	-0.998385145141	0.462653177972	-0.0978564674694	-0.370970556874	0.60473027243	0.120294826748	0.320534623233	-63.5944712644	28.170952127	-83.3605252715
78	0.00277869088724	0.00732154518268	-0.00130965795338	0.0538519712263	-0.0109106071476	0.00178444019667	-0.0407067427041	-0.0163638602508	0.0162428443306	-0.103107595164	-0.145620192131	0.0660931524959	-0.0915735060219	-0.164155845615	-0.266082476057	0.277219140443	0.193533248072	-0.146215383756	-0.00463115684979	-0.459157694526	0.30413707136	-95.7523260861	13.3696005862	-50.6296040652
79	0.0125128670908	-0.0103898963257	0.0102081601777	0.0275186786508	-0.0242158825098	0.0183640074109	0.00931935928109	-0.0983743142849	-0.0610740896535	-0.0292656966245	-0.0166864105648	-0.132332678902	0.0125274116957	0.0857676545489	-0.0935295792913	0.151917933604	-0.0665812328343	0.228041622201	0.240666973729	0.00748995024977	0.331510640046	-85.8239525455	11.3403558506	-55.5128932779
80	0.00617018933651	0.036321205618	0.011181277813	0.168145189776	0.0602866566372	0.0249391918721	0.00780987350414	0.0465403838772	-0.110258459787	-0.0515733517972	0.0423054676745	-0.0812789688927	0.114933807117	0.127481307293	0.0222635108285	0.161250252236	-0.188350031601	-0.012837958261	0.634665854645	-0.441428924646	0.589195963923	-76.4093061882	7.86510779288	-56.0022184682
81	0.0210157892542	0.00376085726794	-0.0106570274266	0.0154122241012	-0.0188403300823	0.0136422317672	0.214696564254	-0.51896727555	-0.0275287925163	0.0219079542039	0.304836124704	0.323334226643	0.0253082321375	-0.131744437229	0.000202962855161	0.589152852628	0.1451540761	-0.0684237074104	0.464751369133	-0.0346695989766	0.486646469425	-74.3282925073	-5.09524531958	-44.3549661472
82	0.0302334030199	-0.126689828875	-0.00131333287024	0.613769902995	0.0175321449513	-0.000461912011803	-0.0499530929514	0.064932495343	-0.116521625058	-0.0784256539232	-0.160068025412	-0.432181589396	0.247933730196	-0.105045997561	-0.475794758269	0.71700087863	-0.261129792876	-0.150146668524	0.062469375136	-0.0926961588496	0.387683914333	-92.5391801615	3.10755145865	-47.6845116952
83	0.209665397148	0.0388400319532	-0.0442477815599	0.228244891143	-0.00667553494918	0.125245168589	-0.219860683731	0.0232212814503	-0.132574688213	-0.017203210008	-0.186619022279	0.141117263659	0.238197669971	0.0114967538426	-0.704551687371	0.114020568624	-0.182977108206	-0.00915299203273	-0.585132599524	-0.133407100685	0.430901277849	-78.0722829626	7.05518748535	-41.8486235919
84	0.0991324275959	0.0722286575486	0.0991564052068	0.362949123026	-0.188093330061	0.316931010117	0.0709963402262	0.040353334431	0.0889780891752	0.444657036122	0.238184052667	0.320954230245	-0.118653536737	-0.125351669181	0.54723409333	-0.284220704006	0.24436316173	0.225011248221	0.0957415837634	-0.54573959077	-0.366646964151	-82.2530720025	16.3495588789	-47.3747356882
85	0.271021700436	-0.287358001792	-0.111179694747	0.320229070716	0.124440159494	0.0492679750138	0.0961836003226	0.241678957694	0.391831651961	-0.107673366587	-0.00249411458325	-0.00709377396182	-0.232595233778	-0.153619460003	0.115794491619	1.0806523476	0.0277316613435	0.0448911462128	0.206824222023	0.370429248731	0.969333322286	-86.6144938966	-28.2998978872	-62.8855504507
86	0.2817882527	-0.19608548177	0.036495271006	0.202016238787	0.0451541796946	0.141729101121	0.0838136073815	-0.0107648872912	-0.485746709231	0.118351355044	0.224821681695	0.109933225963	0.133562193306	0.103048927046	0.154721184164	0.343482935586	0.384480662307	-0.0941615897325	0.734180593025	0.254138305928	0.936664729667	-85.0825148957	-27.4260762674	-60.3106551015
87	0.00529835026349	-0.0113032625692	-0.00393837481531	0.00954185567074	0.00473985167683	0.00326870273519	0.0525410527012	0.124208410348	0.0685540103101	0.24354059914	-0.0809749393858	0.0730008376269	0.0909561219121	-0.0198093188241	-5.62798001791E-5	0.794631900842	0.027382826609	-0.243533781154	0.477892180263	-0.0607935001072	1.26038220466	-77.7946295898	-24.3878760287	-55.3200671057
88	0.00302588048688	-0.0100415594662	0.000202875380996	0.00876049401305	0.003452099001	0.00135149848245	0.12877500623	-0.0509002855542	-0.0985585616966	0.0350312094258	0.0464605971643	-0.237428563448	0.0425689294175	0.0947344780347	0.000102777337258	0.822458898253	0.1839050812	-0.0245631423583	1.54576772317	-0.175481857898	1.49299802579	-75.0827073313	-31.7732454891	-52.2923129539
89	0.0306810445118	-0.0194426543127	-0.0455091128313	0.0136862553821	0.0163835163666	0.0663439561379	-0.115434995774	0.00993545482053	-0.0972455159635	-0.0257276220022	0.0878457718765	-0.265764765629	0.00992236852563	-0.0105645783394	-0.0349253518143	0.6517229886	0.615600626235	0.132062146318	0.962227417994	0.0412907595545	1.10272425735	-76.9524584244	-31.6530246631	-67.7561536541
90	0.00629838104429	-0.00301745508489	0.00510773058045	-0.000162574624718	5.07671503417E-5	0.00312863143037	0.0464103836011	0.0191383139664	0.0224660721206	0.0485564848909	0.0399679402153	0.069747699019	0.0140595976331	0.047864573019	0.0558466395387	0.484194119615	0.139863488628	0.138371591688	0.555561663637	-0.433879623504	0.736050629931	-91.6772662519	-27.6275553048	-70.9425460631
91	0.0931745120678	-0.0305627416411	-0.0650270511563	0.0146142556274	0.0244600327122	0.0481312065783	0.0154374481252	0.0796113633223	0.00453968992126	-0.048326738583	-0.0130137631222	0.00137676974579	-0.097344179688	-0.0843781366344	-0.0498012323306	0.889684467579	0.0559108904682	0.290580196836	0.814283977099	0.456220061743	0.529859569943	-88.3345286707	-32.649638782	-65.2909316557
92	0.00374890052489	-0.00115893914107	0.0106253058728	0.000732968438107	-0.00508623418201	0.0231599049654	-0.0675007225406	-0.072268231905	-0.0325112742607	-0.0856728851679	0.0652159003923	0.0208853489029	-0.0223410811541	0.0191179470453	8.40386139678E-5	1.35721661926	0.272422061462	0.376172760723	1.08585020165	0.304734564126	1.73888116639	-78.122173485	-37.3005663693	-51.4898672125
93	0.00999894672186	0.00728821340722	0.0195962861442	0.00763979084672	0.014859225934	0.0399389532637	-0.0144866633815	0.0215802575157	0.0697046976159	0.0363163960762	-0.0351024974782	0.0260875446071	0.0236632408046	-0.00200299240254	-0.000339421000868	1.66911210714	0.000289302099776	-0.131889305528	1.78460899808	-0.0214138683105	1.50379068128	-70.7119547458	-39.6401501705	-47.4980923985
94	0.0848514046519	0.0381403050753	0.0337199223565	0.0219542518922	0.0148611409947	0.0122300884573	-0.0397527746221	-3.24058567389E-5	-0.00238693264954	0.0354049898766	-0.0072388199208	-0.047254102284	-0.0504596484952	0.0187931105746	0.00055732514999	1.45777287072	0.330951725612	0.28514999279	1.2041398766	0.352539517792	2.12169705067	-81.2897988324	-43.3107331698	-53.744299292
95	0.112047284005	-0.287707819658	-0.232717234188	1.2782582243	1.07931705085	0.937433181773	-0.170755342132	0.310836830015	-0.19955197928	-0.155633038513	-0.185745014034	0.468095531315	0.0366485482349	-0.52521931342	-0.219498877184	1.08724233974	0.118701797191	0.295886000257	0.937911868633	0.297740748599	1.03457009884	-103.968607491	-43.8766922764	-63.3316007384
96	0.0221127546189	-0.0170860836293	0.00175513599921	0.0151076980229	0.0013043137298	-0.00386201407221	-0.0424781950312	-0.187356969519	-0.140527783906	0.0465549827434	0.00507443175303	-0.0878237989919	0.0508635377133	0.044207431444	-0.000109096973247	0.734339025867	-0.0648363921925	-0.0590950115096	0.388342839513	0.0908102970562	0.716853720198	-95.4143854959	-30.1191212225	-50.5599774629
97	0.0105856976576	-0.013526376385	0.0736066362438	0.0314703431788	-0.134060862608	0.675247580366	-0.00652382039199	-0.0226483862711	-0.0581264023338	0.116518172082	-0.349478713377	0.356105933508	0.138960490697	0.169810919126	-0.0344138593651	0.785257407039	-0.0700233973517	0.197684560923	0.291415088373	-0.150483024902	0.798919425596	-99.1096628456	-21.9477828271	-53.0670330361
98	2.4396155601	0.0815681052794	-0.376995251893	0.0575048062367	-0.0527173888147	0.090668503781	0.48500932245	-0.810850373016	0.60892643693	-0.0165752620195	-0.0584240272442	-0.00580266009898	-0.297816137912	0.331235393221	-0.047018096904	0.835831949744	-0.213478952393	0.213577568744	0.799366021993	-0.0975366078685	0.390517623131	-102.646573193	-26.8235835734	-46.5555836143
99	0.388872785338	-0.174662412077	0.430107737307	0.452577434192	-0.0960907011379	0.466388426922	-0.470576272749	-0.239540685919	0.47509942162	0.218452110075	-0.152372710828	-0.0671926361241	-0.352656849598	0.0616430703915	-0.395474293678	0.626778536708	0.0519619050824	0.180624217643	0.125732329299	0.0617865167318	0.620425490748	-100.012736523	-25.8655609135	-67.0155605358
100	0.187780248707	0.0154944596032	0.133593404384	0.0499146562043	0.0100505269825	0.0983678632689	0.070032832086	-0.0265320311205	-0.114605183114	0.0102571138965	0.106535243605	0.0938704060692	0.0456663166829	-0.122810027957	0.211971686204	0.807566317452	0.138636664614	0.429571305911	0.563024259428	0.12346262229	0.565340995206	-110.032238555	-30.5139180748	-59.3086091585
101	0.083750405028	0.00167400313862	-0.135113996903	0.23402595434	0.0225141976527	0.0973766385373	-0.0128065185006	0.277006170994	-0.115389661949	-0.188083869266	-0.198453192094	-0.121349644774	-0.061570166397	-0.231755332638	0.0229477064129	0.174344309726	0.0554011793663	-0.14720484891	0.268723603127	-0.228657982373	0.200248515794	-113.005641775	-10.6768813101	-86.8749237801
102	0.261168577226	-0.218946042679	0.223833858986	0.188773223915	-0.20227031684	0.194418670118	0.131123683072	-0.00179080066895	-0.162907821098	-0.232472356192	0.24149630078	-0.0562918137099	-0.206170841512	0.115160766822	0.270842135232	0.265927452222	0.319421819605	0.0412169322656	0.0168166404099	-0.370265170429	0.617894732916	-114.738644525	-31.4697143442	-69.7394135909
103	1.36716227799	0.219481859144	0.546383338735	0.0851533145532	-0.114259920144	1.0066645753	-0.393316556394	0.112763484321	0.113536878987	0.0861046133646	-0.138179113986	0.304694922945	0.326936543011	-0.0901754680086	-0.305977325182	0.266548610002	0.157149781166	0.00589080366909	0.666984338472	-0.0760409576527	0.523404707924	-122.038625307	-19.7850734117	-69.5675023982
104	0.000500954876064	0.000358238601204	-0.00147461389962	0.0183873428776	0.0886764246919	0.414908143061	0.0465180961421	0.0570854925327	0.000874866405122	0.0793767785259	-0.0882609719738	0.00564027824114	-0.0894499995887	-0.0819199868165	0.0148896850301	0.332556083634	-0.0476433225058	-0.0526945426643	0.595189396751	-0.255993563923	0.415740441164	-150.65083994	-13.5596547351	-100.745067431
105	0.0316529407093	-0.013046832812	0.0423884192851	0.130146686589	0.111416696747	0.357419917717	0.0230500999566	0.0381696689952	-0.057983692452	0.0276133338312	0.0311111433105	-0.0263961313422	-0.00163136658701	0.0383991749239	0.0877737916059	0.277092714821	-0.0666523993133	-0.143856184043	0.578649011494	-0.323165162603	0.34948639418	-140.7166131	-10.8672075467	-95.7089562465
106	0.0790543848853	0.0280318511802	0.0304445666201	0.00938576885654	0.00986708900582	0.00293051704238	0.353212400143	-0.312484420106	0.286417955411	0.130839092558	-0.309561451935	0.149591229332	-0.0944006615406	-0.247747823466	0.00010018896608	0.620277540752	-0.146054152607	0.0942282539405	0.692256609252	-0.0584065260551	0.545171233006	-131.240795563	1.81746808547	-103.810610164
107	0.154283519638	-0.0639627941431	-0.0506543656368	0.0316228145537	0.0213090398862	0.0173549400486	-0.0518473024432	0.212264881962	0.32332759944	-0.117222618923	-0.200194213063	-0.0320558615228	0.0244607108218	-0.275315568929	0.00356920128166	0.441801675908	-0.160952095462	0.0981452752079	0.354997338293	-0.0610590376913	0.551398660021	-148.772501661	-2.82334128802	-104.13404164
108	0.285454920674	-0.212604108044	0.0597729137835	0.238334419125	0.109667949625	0.262754989372	-0.257278424341	0.0748776040328	0.0881261748614	-0.21658327515	-0.2167218471	0.446155519714	-0.0806104946767	-0.133812012873	-0.421715116214	0.0657381488857	0.396392128169	-0.199106301117	0.0369879851141	0.0953210914596	0.17237333957	-132.812373719	-6.31073809082	-109.17238553
109	0.607879314059	-0.312345992745	-0.295336762953	0.168957157409	0.159721550595	0.149744001368	0.0138867835353	0.0271258211844	-0.215000188301	-0.0619505194858	-0.118862610021	0.208498377906	0.0676975472876	-0.249304611138	-0.123358225062	0.385212324233	0.680668588175	-0.0766482851455	0.754534305972	-0.392879516203	0.40773613594	-137.927047748	-16.2316889393	-103.711552545
110	0.044122757593	0.0256012568004	0.067549193609	0.0776212530684	0.109775456028	0.186766400804	-0.077577235034	0.13532689323	-0.436976202145	-0.31695871739	-0.256581287302	0.405374607871	-0.234640315296	0.174473879432	-0.00177026239593	0.470929197968	-0.0609129798362	0.0816442204709	1.26993570774	-0.0820161382228	0.687204813805	-13.7952108779	-26.759193143	-132.911716402
111	0.016375073809	0.0327764039344	-0.0161062235065	0.0810405693938	-0.0375258765638	0.0181678050509	0.0534270563662	-0.124737845219	0.105857510821	-0.165033449826	-0.150688077484	-0.0245751290591	0.0764122161368	0.0099126001611	-0.0314405044736	0.586551878125	0.496550598617	-0.232723090499	0.922719875264	-0.177858808784	0.660950848823	-3.86863039068	-29.1277438151	-131.967794424
112	0.0449775823739	0.00623833514058	-0.00137257520118	0.0295189825432	-1.18369186869E-5	0.0041344486074	0.0532909804732	-0.0247556815262	0.116676968858	-0.130678141308	0.0569558842208	-0.103592462499	0.0940640311544	0.105605076579	0.0234197915264	0.645657515078	0.782833220616	0.247265230932	0.375830818867	-0.472364782552	0.281712240862	-9.4489265435	-37.3362514381	-133.348194594
113	0.00356242269839	-0.0016839797517	0.00419656205153	0.00882006712344	0.00721458308058	-0.000396831575698	0.151387695315	0.0386919940996	0.029927957827	-0.0738008229479	0.0219401460024	0.000572860116007	0.0725183905528	-0.0254368846444	7.18684113121E-5	0.51771531342	-0.0749213998311	0.020989556701	0.773238128978	-0.263151740942	0.840903807816	-21.8348044857	-26.4056726327	-140.155407817
114	0.0234212059225	0.041552920979	0.0394742573779	0.0698460997428	0.0825985952628	0.0701477141161	-0.519734539634	-0.0124827796863	-0.0465125416634	-0.319686953855	-0.43215075206	-0.0493166860825	-0.060443512505	0.0216809730807	-0.00811543280972	0.902176933143	0.290065853338	0.349979912545	0.625743736268	0.205636262447	1.00184971468	-10.4912271064	-37.6439966678	-123.389271918
115	0.0316771397621	0.0435541986552	0.00387710474095	0.0520485758872	0.00727513365896	0.00977801893681	-0.0191746632333	-0.00912946397034	0.217806135978	0.0733873593312	0.0866156484288	0.539493689477	-0.341522055515	-0.277396144554	-0.000282270912559	0.740774879764	0.0970751385672	0.0341810151992	0.735875578959	0.155924422587	1.39041929729	-36.8322567574	-24.2794667239	-120.856791609
116	0.170561886455	0.00935812468596	-0.0586177130934	0.0313689767779	-0.00333485383843	0.032349741473	-0.0696424412798	-0.0371883654847	0.00977407320705	-0.000817321548709	-0.0217795087104	0.0263240676642	-0.00987798774994	-0.00487994576613	-0.0920663848067	0.5126637173	0.157972600827	0.0570495993861	0.253670009748	0.00243894433777	0.596184921184	-11.1551728531	-17.6157076024	-123.00763168
117	0.0156429276978	0.0356250134383	0.00189227349994	0.0917630663086	0.00245507087431	0.000565062602265	0.0670559515333	0.0271168864759	-0.00220488887198	-0.00391995568984	0.0799211768006	0.0546884584014	0.0162785903551	-0.0954843985101	0.082040480889	1.12292124258	-0.247642509338	0.199394384963	0.56030425873	0.0641432671456	0.47981463702	-21.2754737096	-23.3929557818	-115.303582228
118	0.47579829947	-0.25672253342	-0.0978935803697	0.246228784435	0.014874592844	0.0853427753723	0.0851668620312	0.211549724725	0.457980651003	0.11463979889	-0.0245303033904	-0.113545102346	-0.0762874259363	0.0379068955626	0.0246274219596	0.19774959988	0.0847270908783	-0.0236947262567	0.616086524728	0.0538684931911	0.206540162823	-13.5430061067	-15.3550636307	-126.809375516
119	0.0664436641191	-0.0167650673124	0.0162903529772	0.00285455992254	-0.00259372779554	0.016063489443	-0.0447299932505	-0.0928026545658	0.0208478297257	0.0100729914951	-0.0105766937579	-0.0142124750192	0.0092969247185	-0.0799245694567	-0.0348475736953	-0.134115220035	0.0622297987461	0.0438367294575	0.494366333927	0.0113199190637	0.190822872943	-17.4254959285	-6.35336366328	-121.240859869
120	0.257281641611	-0.0474799575509	0.177625691047	0.0657684475187	-0.0627158596153	0.130558394468	-0.158391090541	-0.258611165853	0.343008820159	0.0231965346064	0.179661101945	-0.105834247918	-0.157225246604	-0.0504121645645	0.162076111818	0.719585328252	-0.169312248569	-0.234857234922	0.953999171752	-0.176028442677	0.40820053908	-8.18199858058	-5.73487010573	-118.458717337
121	0.0187568437221	0.0145470899403	-0.000290532973622	0.0169047452053	0.00530137102341	-0.000183298212877	0.0315533487161	-0.04431528627	-0.0905906660338	0.16805603888	0.0732658833665	-0.272662206168	0.0251474011868	-0.380425184046	-0.000114086283991	0.526434153216	0.156806854671	-0.102692508167	0.705412079489	-0.0295851516285	0.373826167305	-20.0182336788	-16.1097859456	-114.861658042
122	1.19626894042	-0.7161929354	-0.83715447566	0.85843950302	0.294895460245	0.679117027117	-0.330622279844	-0.110572733101	-0.0858344421958	0.266775075145	-0.204607597425	0.236651946673	-0.0139702490823	0.0519405189996	-0.339907995267	0.336666375401	-0.131687147148	0.0263902251387	0.357500648621	-0.0764056615328	0.210200138787	-22.5508330524	-17.2948186706	-129.88326207
123	0.139625972329	-0.0677489590367	-0.0146887417021	0.0319037676328	0.0113396871068	0.0147102040643	0.00226052301294	-0.0522628041707	-0.129088448126	-0.00702739531485	0.00140573954368	0.00734414447624	-0.00474239372646	-0.024137446399	0.0747323579717	-0.0568172837988	0.124575356745	-0.341291412388	0.100585132044	0.0653130094991	0.683234475196	-20.2714420753	-10.1910934536	-143.279255388
124	0.245827250195	0.00286250053496	-0.096981406213	0.00344613648159	0.000192046467001	0.0409227009548	-0.0253817074414	0.0366950210755	-0.115209572441	0.00131743419293	0.0878847238558	-0.00977394341819	0.0239054791941	0.0113174777918	0.0187402910326	0.486767679925	0.0475036096716	0.336224316494	0.756739100255	0.198011741531	0.49657114542	-27.3020909583	-15.2046601813	-144.888972726
125	0.051904705344	0.0142815434672	-0.0778522662633	0.0211237865314	-0.0324209034624	0.121856832598	0.162227861841	-0.0887432130947	-0.0836742494759	-0.0211856479252	-0.0123127861214	-0.0706240798734	0.19580880657	-0.172763440442	0.103008197509	0.581821403375	0.0274977445814	-0.24097463187	0.732326953922	-0.144264384545	0.329022703426	-33.8239976532	-19.5147664196	-128.736942326
126	0.0248073547986	-0.0196208655576	-0.00343115254554	0.00677690120094	-0.000359439761924	0.0074012851208	0.159293638151	-0.0324945365383	-0.146614904741	0.0109982489041	0.245228857975	0.102321741285	-0.0598461100949	-0.00178428305521	-0.00030230001981	0.392176037025	0.165436598016	-0.083256743636	0.50551477839	0.0665376448227	0.590764381518	-28.5844008772	-10.5181844376	-122.350110834
127	0.0730697148375	-0.0901559933269	-0.0386997609046	0.391231618103	-0.108195722157	0.169842738947	-0.175544748691	-0.117312189878	0.0856558998389	0.279333412209	0.206213926733	-0.0653314036094	-0.112194113631	0.0283367522175	-0.0517923445567	0.53705387309	0.179410791522	-0.0403098048764	0.457712617652	0.266939342323	0.831538279485	-34.9136555304	12.1908971951	-157.195923252
128	0.167322134795	-0.055966588132	-0.077894399267	0.0775878302641	0.0933964850256	0.119286899165	0.14533203144	-0.0940064899319	0.260997018046	0.161896594792	-0.0838126667042	0.23970779774	0.0608534157552	0.115334209225	-0.055760496125	0.213597465715	-0.308014533088	-0.081016087548	0.731284074763	0.234882736918	0.489398655862	-33.3430816866	-9.42767278466	-151.524881528
129	0.332092795937	0.00360490585322	-0.0193060683429	0.110459288361	0.0231958199202	0.063737632567	-0.0131133252373	0.0959369824515	0.219320663092	-0.00757283592284	0.183494279665	0.198855282876	-0.396106273009	-0.342921852585	-0.0981664536069	0.471162711191	0.177434147637	-0.0336603151365	0.776120037468	0.139060657222	0.245546128091	-41.1610931731	1.13474611902	-151.349361632
130	0.15728202268	0.156964917318	0.0288312213375	0.674376467069	0.353501558801	0.206854831786	0.0262859969704	0.035812043473	-0.0969927202835	-0.100596717775	-0.0857588293703	0.0533106400129	-0.00888090210886	-0.0398251951499	-0.132617567637	0.566302582427	-0.0159841231814	-0.161047360943	0.120192757787	0.151629208405	0.439554984561	-35.1504748689	2.60845471925	-159.922986436
131	0.00741823427847	-0.00341784905407	0.0121779276566	0.0046700598766	-0.00462468785746	0.0135212119873	0.0567492208729	-0.0676827134197	-0.0314560574269	-0.155839774439	-0.101006526045	-0.0647580472792	0.0580023003744	-0.146901314373	-0.000152392962932	0.505481263466	0.0512040742806	-0.262273740432	0.712467409597	-0.0411823109077	0.478956744394	-38.6779837135	-3.08725663074	-145.092390509
132	0.0637854735189	0.00442198020998	-0.0477354107932	0.0167036596814	0.00440852481601	0.047158060081	-0.162126551849	-0.0822310144234	0.0860803309416	0.00143171815084	0.0347804591682	-0.0877702800985	-0.0608013587095	-0.00728993766381	-0.00627170153925	0.147062245886	0.0750037763964	-0.0435847195362	1.03877235183	-0.0317167347025	0.56925937004	-29.5323690265	-1.81967886437	-145.120439357
133	0.0181743635444	0.00456649347412	0.000406446548747	-0.000957934697371	-0.000820942017254	0.00125174319484	-0.0818775579184	0.232971200818	0.115677068088	-0.219801582824	-0.134423266807	-0.23193491771	0.0111923570222	0.0725871356604	-0.000963275345115	0.891553442984	-0.178632785924	0.187873197452	1.60540810487	-0.0233911867608	0.695768568319	-26.5794147623	4.00737820612	-161.993238583
134	0.00153857211522	-0.0613044707256	-0.0213223077209	0.375636614122	0.152742386537	0.0607434921434	0.140952378917	0.0452804854675	-0.0555231563165	-0.270777810648	-0.0318942395509	-0.25777182847	-0.106868067596	-0.0280879497188	-0.0100166517267	0.353192111874	0.0246057171302	0.0967725210998	0.922259835654	0.119728416675	0.427490339389	-28.1649543916	-6.4150603621	-147.741776752
135	0.223878937468	-0.231984118143	0.0535999071385	0.249571302232	-0.0542832012167	0.0243404810309	-0.120627472528	-0.0542094777578	0.208499752856	-0.139319093776	-0.0644224415635	0.00323639418637	-0.0683314221123	-0.198265482042	-0.0668257470172	0.251837308411	0.0205816998361	0.0100538166691	0.624300803261	-0.0896144134794	0.243321023977	-36.2289936992	-11.138213551	-130.856356416
136	0.00668067177076	0.0139460266027	0.0121436263664	0.171870698825	0.0725859960688	0.0808754254217	0.039820568771	-0.0338220250927	0.16062686185	0.102771189094	-0.0821641450952	-0.0061111785334	0.0130346502264	-0.0325393199604	-0.025262055715	0.312337448287	-0.040078562147	0.0747214968851	1.2189857491	-0.139951859101	0.930696145228	-47.145105771	-11.1746693342	-123.130183849
137	0.105103644132	0.0859897688369	0.00555343195589	0.0807928233268	0.0122049187985	0.00294161256018	-0.184962471347	-0.0188986198259	-0.0413369734346	-0.382475255028	0.0854721257695	-0.105558511107	-0.209183724924	0.106353414344	0.0283104002526	1.0922456841	0.40195586439	0.05247846961	0.520252559362	0.116348044185	0.411271875097	-40.3228455356	-3.85098251117	-124.415861305
138	1.27096386955	-1.07575672302	0.328655347303	0.921325678852	-0.279175615556	0.084427428595	0.309283152682	0.222411833558	0.316551695357	-0.102552038201	-0.120990514232	-0.0946114980481	-0.0249468098997	0.241461687741	-0.107969072042	1.10596584048	0.386132571559	0.0911409455417	1.4992797576	-0.242607957141	0.483026429913	-33.320256855	9.00499473608	-138.681869635
139	-0.00288545577041	0.000662464210653	0.000405314925968	0.00137859067473	0.022183869745	0.0399226698716	0.119696113981	-0.364979811168	-0.518998120783	0.111186051408	0.0754800649339	-0.233882364955	-0.121991286548	-0.106620431333	5.44664604154E-5	1.21277005187	0.41508858757	0.04456596349	1.20270456625	0.0807217617102	0.707819896167	-53.2925566573	23.3666047129	-157.26427952
140	0.010054262474	-0.00161040975112	0.0192917705069	-0.00348973148928	-0.000880936136053	0.0199916726459	-0.0989333478592	-0.16061410719	0.116051893641	-0.0948562772785	-0.244932081519	-0.148049157007	-0.220706241216	-0.0734733110156	-2.05992062474E-7	0.848021356959	0.0348169261507	-0.10444546505	0.670416039542	0.263638395473	0.945278501212	-43.7389469931	22.9676165871	-175.269763927
141	1.00722132856	-0.688408292583	0.0665358098504	0.77085733699	0.00428231416581	0.022207283598	-0.510025623658	-0.323907209705	0.348087070267	-0.231377909602	0.114902024278	-0.0527468570966	-0.492152122987	-0.167634398524	-0.174459089544	1.26014427884	0.70931957853	-0.0344569028049	1.42930236764	-0.128679865644	0.523069146513	-56.1756840166	26.0838735048	-166.24400996
142	0.113175502829	0.116270276766	0.0365759927545	0.095794116044	0.0874922998864	0.0298982166974	-0.5137892927	-0.0904641101034	0.438936186553	0.555304641406	-0.223996928727	0.202402305573	-0.266724649436	-0.0158725339422	-0.000401806926107	0.678458271626	0.141133307935	0.0675690861129	0.523064002067	-0.0293577868867	0.685033936806	-58.181912903	14.7557919744	-161.297913658
143	0.0189903491355	-0.00935260068879	-0.0124345000902	0.00719708252626	0.0195056146118	0.00970712207448	-0.344960310652	-0.253737498503	-0.375280717356	0.0959681887955	0.0317449268709	-0.13809567055	-0.118884623875	-0.119221944897	-0.000696497238656	0.46691333816	-0.00509117006171	0.0568807252934	0.375577775707	0.181848117025	0.464010394433	-95.0181524396	-26.5473312422	-148.645888326
144	0.062543693988	-0.0519745898871	0.0743922486267	0.0856828196508	-0.0139996798212	0.190155346113	0.0559800837401	-0.164707029857	0.0502062382898	0.276754190142	-0.0476441063917	-0.0485639248765	0.022468448607	0.0336381219712	-0.00853335763983	0.335196674285	-0.0678958623419	-0.225579784719	1.14734344199	0.488398786381	-0.055813117311	-104.498762107	-28.1076991251	-142.436730927
145	0.0187974328807	-0.00593862634944	-0.0230918986044	0.0564885514131	0.0297097856443	0.0135817997141	0.330649090134	0.0578799948647	0.354708482406	0.0273631892701	0.0931721788392	0.271062491248	-0.0801476028769	-0.209654229161	0.532202487982	0.682451200457	-0.611396821342	-0.175005036647	0.589596811418	0.775773892745	0.673712185402	-100.310266397	-35.7675566437	-143.935387238
146	0.0107885794734	0.0102443545579	0.0457574439633	0.245624743747	0.209174558167	0.273966271267	-0.105852138813	0.243038420247	-0.0480632438872	0.221772217947	0.480297467112	-0.117945921551	0.0215556944819	-0.394247028758	0.0200826729802	0.808245450334	-0.335220674187	0.139652445757	0.688013672474	0.150281222001	0.916862254644	-93.8171322317	-29.6353484462	-146.349351609
147	0.0547912103	-0.130481822907	-0.2333587039	0.304333622022	0.539846199041	0.95613288792	-0.494421898958	0.0402322220181	0.0996093298144	0.136977939029	-0.108067247216	0.0694337267955	0.122720578524	-0.249201005402	-0.112446797262	0.980428299897	0.126967743146	0.302587982327	0.146870545444	0.265261158866	0.99513014061	-94.5108872373	-37.0396184127	-157.854412891
148	0.0675114806774	-0.159373209544	-0.0060349014106	0.377563908344	0.0152930298882	0.00187117379338	0.0882409553161	0.0196638654953	0.0375344522539	-0.108652629947	-0.0802479050994	-0.227287124725	-0.00311102490555	0.16590941101	0.124359546801	0.793359769712	-0.108944386272	0.224232315219	1.17101498393	0.587867713399	0.68132999313	-67.0657305549	-21.3896378473	-157.377484885
149	0.0764004646031	-0.0212969335993	-0.0107929822174	0.0591069614936	0.00138628111109	0.0182996408675	-0.0606500574345	0.052307172357	0.0379118170195	0.0210180531	-0.0456289986466	0.0871072659354	-0.00900723427028	0.0529036553321	-0.00201848613602	0.519701545833	0.381543180436	-0.4429654053	0.533392693148	-0.0167865979851	0.313798304387	-99.1761730784	-18.0365088348	-155.79376804
150	0.0379563356181	0.0579181755767	0.0691415353151	0.0991498592425	0.0814658116055	0.188099409071	-0.0873036033862	-0.0147055008006	-0.05913560806	-0.0262958465924	-0.0778831925596	-0.0350318226478	0.0134922249916	-0.00532968469344	-0.00688170923782	0.27767574812	0.0587927453037	0.163847797161	0.892607773526	-0.214714925344	0.552523627012	-88.9505140839	-24.2756027825	-163.279154739
151	0.129963360259	0.0369350237277	0.171450569558	0.0615070867261	-0.0286504656628	0.325969319651	-0.0614220811942	-0.370660248986	-0.0390450896226	0.0848058090115	-0.0585655999092	0.188770589313	0.10742709718	-0.2938757343	0.0151299199289	0.123664768066	0.205769586893	0.0921603913471	0.501502778521	-0.0320729586794	0.302485641941	-95.6229604063	-12.4109824471	-154.297633563
152	0.100136899719	-0.0317601391931	0.122580504056	0.051004737083	-0.0419538278852	0.146882126931	-0.0113519896306	0.150946778848	0.144509455377	-0.0477564488096	0.0581357895421	0.121261753271	-0.0655385007849	-0.025287266462	0.0422149491031	0.189975369859	0.0608924325315	-0.0621466326934	1.16976570705	0.0876610777071	0.752323325032	-102.455704476	-6.21357509767	-161.149648443
153	0.015257494486	0.00347119773274	0.00563250270418	0.0243566743151	-0.00506009101007	0.0077232319746	-0.0541370994375	-0.0627733493326	0.0307389133286	0.214699288266	0.107113628193	-0.101627394047	-0.0184500084459	-0.0191869894272	-5.9322447588E-5	0.489863897865	-0.00622125497434	0.00237671214673	0.427518122606	-0.0968191577531	0.294324349759	-90.2613612971	-16.8169797969	-164.201449121
154	0.486463933637	0.159545650532	0.192653935637	0.605286408886	0.186007961445	0.33487620564	-0.132116256264	-0.0835745838776	-0.112771787535	-0.113714407061	-0.0953866113699	0.0494470221884	0.0740662619348	-0.0358197097367	-0.172520590832	0.34401334542	-0.235163842409	0.0661818683842	0.127457638837	-0.0436699251252	0.259352850541	-87.8538979788	-16.8760127765	-149.095089649
155	0.00829018723941	-0.0136524766899	0.0119222500455	0.00710255626486	-0.0136285456557	0.0173407816064	0.0301502658841	-0.263988769938	0.0631092731184	0.119521235123	-0.363700651557	0.0864346302625	0.170566754742	-0.110095873886	0.000473847530899	0.329264394344	0.0762004889218	0.000386601275595	0.709883356183	-0.0924618034083	0.535373719771	-84.4921350899	-13.5189175685	-138.439223915
156	0.215155805232	-0.108600023741	-0.0994876445735	0.163985338964	-0.00291566680013	0.0811555810467	0.0932646334473	0.0464326520718	0.102099767761	-0.0211209682047	0.218726290086	-0.193862103008	0.0473220043778	0.0634905535415	0.285075347633	0.48561890495	-0.56133605825	-0.283483186055	0.277526456506	-0.113557213071	0.605993779567	-79.5635030792	-13.4620246553	-156.019161385
157	0.00154178523557	0.00194870082429	0.0210250340906	0.010000192332	-0.00584153573157	0.0573706974972	0.0558361685129	0.256707230295	0.000627511643866	0.0369620255386	-0.075028967935	-0.0593885536658	0.0146578738641	0.0337830932968	-0.000512221801923	0.730197553876	-0.0417473121325	0.221023244569	0.469317302347	-0.0534611176107	0.612139921116	-74.331136347	15.5364880066	-124.630432481
158	0.0104432724351	-0.00333241224278	-0.0095469470443	0.0518951442421	-0.0141633312336	0.0274362979844	0.0149350122702	-0.0963466723693	0.212725442906	-0.10996093928	-0.00407618522017	-0.112487966008	0.0853084998341	-0.0440549121355	0.0576160065147	0.982948756586	-0.105238334075	-0.120628973271	0.956321428325	-0.04003590645	0.298547512832	-78.1321322837	-3.26931312598	-121.222701482
159	0.0947312923996	-0.0557262260029	-0.0604137093245	0.0287668793822	0.0463731550512	0.0702244053979	0.0348203309882	-0.018676344116	0.201669273534	0.18067740794	0.139238059567	0.200707261142	-0.112193526614	0.446348479324	-4.41177097384E-5	0.428066949979	-0.0458445001686	0.0398192708028	0.753062570075	0.0665964932821	0.423100009892	-69.9696456299	-0.970939712123	-128.94360284
160	-0.0289343514083	-0.020850494457	0.00159196825185	0.0227194621553	-0.0291707304449	0.0410802283741	-0.0881045251817	-0.46283691182	-0.0392282412592	-0.0653354435234	-0.153805306613	0.00131927215724	-0.212140005266	-0.0420035888341	-0.000122371088383	0.942126901815	-0.166627633045	-0.120828088314	0.705182667861	0.00223973083231	0.532816223097	-74.1207320389	2.38292409485	-124.038153373
161	0.80288487773	0.154936298959	-0.206900374451	0.926112665041	0.637639276466	0.567259084962	-0.251381814384	-0.0813969247638	0.220482815296	-0.0243195489935	-0.424809031758	-0.099395382626	0.374227342198	-0.300227724485	-0.606191323537	0.561804750575	-0.0584942011146	0.0148076464401	1.05116191292	0.368766969947	0.457646437518	-78.8599659564	0.684784240411	-130.942817081
162	0.0253186646203	0.00307541786462	0.0613128318175	0.199898570985	0.0572255953047	0.140365513539	0.344472094316	-0.212953763643	0.121445375613	0.232293076007	0.158067964131	0.210537915721	-0.133333141178	-0.119851992965	0.000922670035932	0.482712276284	-0.188792196042	0.0619895588228	1.04495249549	0.0987064259215	0.404512457074	-83.1981785462	-1.27623657707	-119.504351724
163	0.0180256458748	0.00747628809678	0.000480848239015	-0.000727646972025	-3.44539967095E-5	5.84848647183E-5	0.0656269463721	-0.179867543331	0.076232029696	-0.103434315811	0.159281454077	0.0466205712264	0.146092319065	0.0948920228821	-0.000107068303702	0.332212022314	-0.0731997952091	-0.0027471893089	0.66316962293	0.070667386387	0.31945327244	-77.2903627191	-9.43488454071	-146.389448689
164	0.139333445814	0.0448509860268	0.180296865	0.0166211175192	0.0621169914045	0.2314108373	-0.0248660955477	-0.355362331116	-0.0361707977469	0.0744690002702	-0.129479111388	-0.163725475572	0.118010196347	0.186531234706	-0.0126714441483	0.463870132031	-0.288044041827	-0.109661155269	1.25809715226	0.276256172995	0.706317437203	-64.7393114851	-11.1984551684	-155.934638275
165	0.00572713044407	0.0237585198692	0.000122198483878	0.0340992501563	0.016739383944	0.00890418889262	0.121654453531	-0.188649445523	-0.243555935539	-0.269158432629	-0.0756435453293	-0.0621729493163	-0.0833481866648	0.063377516441	0.000429482151714	0.853749801757	-0.142579112778	0.0407425361778	0.501198724036	-0.0681071714619	0.448155396383	-69.9361297575	-2.56252325251	-153.231975222
166	1.07814800764	1.36915110295	0.247455084301	1.7628750847	0.306807658272	0.066435887598	0.134037084288	-0.266099099349	0.0938443769637	-0.0179635625861	-0.152934700911	0.205079884916	-0.309083613404	-0.175366782549	-0.0188797399526	1.49481913628	-0.135636235883	-0.190053436605	1.38222361347	0.0565466982623	-0.0324285806228	-77.2401523106	9.98137004094	-141.075802783
167	0.0459992467322	0.0290672649495	-0.0114104568059	0.0276904754953	-0.00409451984579	0.00417647502949	-0.0100734244735	0.00649817836595	-0.0176179975069	0.0219944136408	-0.0503871536729	-0.012055544857	0.0558453845546	0.0372236212192	-0.0164095516563	1.73373117907	-0.336269908514	0.100787425746	1.3259397409	0.601249527669	0.92600793809	-45.1691051717	28.8078789971	-125.121913924
168	0.00356738765882	0.00718497939542	0.00216282577508	0.000434564962458	0.0103761155133	0.0115796276414	0.0446951364241	0.255216384842	-0.223766813566	0.0593063034193	0.148180904895	0.213026516715	-0.0233485375709	0.301080663304	-0.000102748270581	1.47921043532	-0.247968147252	0.103496688567	1.44157717982	-0.231444125836	1.0044866461	-60.884599323	20.8447712409	-121.422765798
169	0.00392923952912	-0.00689412246337	0.00504799738266	0.0101862370951	-0.00867441801419	0.0101193197436	-0.0625920211895	-0.0320014802922	0.0189783847748	-0.0523085484491	-0.0541349672185	0.0572332353856	-0.00671096356637	-0.0412730628066	7.81847163716E-5	1.64328867531	0.268944952979	-0.0629002228635	1.37610278714	0.0950582140643	0.613746033725	-73.6904297467	22.7339242672	-106.609520669
170	0.00555760890808	-0.00345798656953	-0.00645958968878	0.00215338638374	0.00364312893755	0.00487591166203	0.0630865978655	0.0104369991935	0.0370891158611	0.0721895596946	0.123667053151	0.13241899731	0.00434676827032	-0.0981209959735	0.000292325076334	1.33952544307	0.0922907711525	0.132559513518	1.14783120507	-0.524358456715	1.05602984996	-65.6855690105	22.4785128547	-100.644259595
171	-0.00371268377993	0.0147879715358	-0.00670769062191	0.0154400228457	-0.0165920267585	0.0203282738738	-0.0743882614304	0.234781442071	0.389721595678	-0.295027792425	0.0553743050407	0.0780093597655	-0.081569216729	0.277672889315	0.000128252406062	1.98577106439	-0.733816236523	-0.28781096526	1.24344626302	0.0698825890597	1.23244965392	-54.2527723289	31.2544961612	-114.584901102
172	0.0771017093206	0.034976400891	0.0544927313774	0.0047418108683	0.0273207809	0.0501416989396	-0.17616606022	0.117261826594	0.0858814203106	-0.178520249267	-0.0656612712679	0.107278235528	-0.210372371989	0.0100791572263	-0.138966438391	1.74776622692	-1.02213684182	0.244404204309	1.24379199942	-0.385860600389	0.517717060778	-52.8193089064	21.2557082779	-110.518499768
173	0.00919377633368	-0.00680967021894	0.00497102123851	0.00905337352516	0.00132321786425	0.0107580666631	0.0391199061383	-0.00317803101144	-0.00806212544459	-0.000496968509959	0.0905719409011	0.0182934869338	0.0221705199678	-0.00740964253371	-0.000736365523586	0.976135483155	0.107825618276	0.359924191073	1.16559969538	-0.0379520488678	0.939622835318	-63.1918220099	8.41406527677	-106.849966441
174	0.603431741548	-0.0682811430543	-0.100146260279	0.99369430844	-0.529290094137	0.3241968538	0.122193479463	-0.0114896582662	0.0240660117817	-0.299521923544	0.281495353187	0.217854624655	0.028517721643	-0.0865110392066	0.348356891239	1.22760528433	-0.804377606743	0.512397954795	0.906709847555	-0.181968462766	0.486945496421	-49.4108131717	15.969209741	-119.734115059

精密化 TLSグループ

ID	Refine-ID	Refine TLS-ID	Selection details	Auth asym-ID	Auth seq-ID
1	X-RAY DIFFRACTION	1	( CHAIN A AND RESID 1:9 )	A	1 - 9
2	X-RAY DIFFRACTION	2	( CHAIN A AND RESID 10:19 )	A	10 - 19
3	X-RAY DIFFRACTION	3	( CHAIN A AND RESID 20:42 )	A	20 - 42
4	X-RAY DIFFRACTION	4	( CHAIN A AND RESID 43:50 )	A	43 - 50
5	X-RAY DIFFRACTION	5	( CHAIN A AND RESID 51:65 )	A	51 - 65
6	X-RAY DIFFRACTION	6	( CHAIN A AND RESID 66:72 )	A	66 - 72
7	X-RAY DIFFRACTION	7	( CHAIN A AND RESID 73:78 )	A	73 - 78
8	X-RAY DIFFRACTION	8	( CHAIN A AND RESID 79:88 )	A	79 - 88
9	X-RAY DIFFRACTION	9	( CHAIN A AND RESID 89:93 )	A	89 - 93
10	X-RAY DIFFRACTION	10	( CHAIN A AND RESID 94:102 )	A	94 - 102
11	X-RAY DIFFRACTION	11	( CHAIN B AND RESID 17:27 )	B	17 - 27
12	X-RAY DIFFRACTION	12	( CHAIN B AND RESID 28:45 )	B	28 - 45
13	X-RAY DIFFRACTION	13	( CHAIN B AND RESID 46:58 )	B	46 - 58
14	X-RAY DIFFRACTION	14	( CHAIN B AND RESID 59:66 )	B	59 - 66
15	X-RAY DIFFRACTION	15	( CHAIN B AND RESID 67:82 )	B	67 - 82
16	X-RAY DIFFRACTION	16	( CHAIN B AND RESID 83:96 )	B	83 - 96
17	X-RAY DIFFRACTION	17	( CHAIN B AND RESID 97:112 )	B	97 - 112
18	X-RAY DIFFRACTION	18	( CHAIN C AND RESID 61:70 )	C	61 - 70
19	X-RAY DIFFRACTION	19	( CHAIN C AND RESID 71:83 )	C	71 - 83
20	X-RAY DIFFRACTION	20	( CHAIN C AND RESID 84:94 )	C	84 - 94
21	X-RAY DIFFRACTION	21	( CHAIN C AND RESID 95:115 )	C	95 - 115
22	X-RAY DIFFRACTION	22	( CHAIN C AND RESID 116:131 )	C	116 - 131
23	X-RAY DIFFRACTION	23	( CHAIN C AND RESID 132:141 )	C	132 - 141
24	X-RAY DIFFRACTION	24	( CHAIN C AND RESID 142:157 )	C	142 - 157
25	X-RAY DIFFRACTION	25	( CHAIN C AND RESID 158:184 )	C	158 - 184
26	X-RAY DIFFRACTION	26	( CHAIN C AND RESID 185:193 )	C	185 - 193
27	X-RAY DIFFRACTION	27	( CHAIN C AND RESID 194:206 )	C	194 - 206
28	X-RAY DIFFRACTION	28	( CHAIN D AND RESID 60:88 )	D	60 - 88
29	X-RAY DIFFRACTION	29	( CHAIN D AND RESID 89:123 )	D	89 - 123
30	X-RAY DIFFRACTION	30	( CHAIN D AND RESID 124:139 )	D	124 - 139
31	X-RAY DIFFRACTION	31	( CHAIN D AND RESID 140:168 )	D	140 - 168
32	X-RAY DIFFRACTION	32	( CHAIN E AND RESID 1:9 )	E	1 - 9
33	X-RAY DIFFRACTION	33	( CHAIN E AND RESID 10:23 )	E	10 - 23
34	X-RAY DIFFRACTION	34	( CHAIN E AND RESID 24:35 )	E	24 - 35
35	X-RAY DIFFRACTION	35	( CHAIN E AND RESID 36:46 )	E	36 - 46
36	X-RAY DIFFRACTION	36	( CHAIN E AND RESID 47:60 )	E	47 - 60
37	X-RAY DIFFRACTION	37	( CHAIN E AND RESID 61:72 )	E	61 - 72
38	X-RAY DIFFRACTION	38	( CHAIN E AND RESID 73:80 )	E	73 - 80
39	X-RAY DIFFRACTION	39	( CHAIN E AND RESID 81:85 )	E	81 - 85
40	X-RAY DIFFRACTION	40	( CHAIN E AND RESID 86:90 )	E	86 - 90
41	X-RAY DIFFRACTION	41	( CHAIN E AND RESID 91:95 )	E	91 - 95
42	X-RAY DIFFRACTION	42	( CHAIN E AND RESID 96:102 )	E	96 - 102
43	X-RAY DIFFRACTION	43	( CHAIN F AND RESID 17:45 )	F	17 - 45
44	X-RAY DIFFRACTION	44	( CHAIN F AND RESID 46:58 )	F	46 - 58
45	X-RAY DIFFRACTION	45	( CHAIN F AND RESID 59:66 )	F	59 - 66
46	X-RAY DIFFRACTION	46	( CHAIN F AND RESID 67:83 )	F	67 - 83
47	X-RAY DIFFRACTION	47	( CHAIN F AND RESID 84:96 )	F	84 - 96
48	X-RAY DIFFRACTION	48	( CHAIN F AND RESID 97:112 )	F	97 - 112
49	X-RAY DIFFRACTION	49	( CHAIN G AND RESID 61:70 )	G	61 - 70
50	X-RAY DIFFRACTION	50	( CHAIN G AND RESID 71:105 )	G	71 - 105
51	X-RAY DIFFRACTION	51	( CHAIN G AND RESID 106:118 )	G	106 - 118
52	X-RAY DIFFRACTION	52	( CHAIN G AND RESID 119:128 )	G	119 - 128
53	X-RAY DIFFRACTION	53	( CHAIN G AND RESID 129:137 )	G	129 - 137
54	X-RAY DIFFRACTION	54	( CHAIN G AND RESID 138:146 )	G	138 - 146
55	X-RAY DIFFRACTION	55	( CHAIN G AND RESID 147:169 )	G	147 - 169
56	X-RAY DIFFRACTION	56	( CHAIN G AND RESID 170:181 )	G	170 - 181
57	X-RAY DIFFRACTION	57	( CHAIN G AND RESID 182:195 )	G	182 - 195
58	X-RAY DIFFRACTION	58	( CHAIN G AND RESID 196:206 )	G	196 - 206
59	X-RAY DIFFRACTION	59	( CHAIN H AND RESID 60:68 )	H	60 - 68
60	X-RAY DIFFRACTION	60	( CHAIN H AND RESID 69:84 )	H	69 - 84
61	X-RAY DIFFRACTION	61	( CHAIN H AND RESID 85:100 )	H	85 - 100
62	X-RAY DIFFRACTION	62	( CHAIN H AND RESID 101:139 )	H	101 - 139
63	X-RAY DIFFRACTION	63	( CHAIN H AND RESID 140:161 )	H	140 - 161
64	X-RAY DIFFRACTION	64	( CHAIN H AND RESID 162:168 )	H	162 - 168
65	X-RAY DIFFRACTION	65	( CHAIN I AND RESID 1:33 )	I	1 - 33
66	X-RAY DIFFRACTION	66	( CHAIN I AND RESID 34:51 )	I	34 - 51
67	X-RAY DIFFRACTION	67	( CHAIN I AND RESID 52:72 )	I	52 - 72
68	X-RAY DIFFRACTION	68	( CHAIN I AND RESID 73:90 )	I	73 - 90
69	X-RAY DIFFRACTION	69	( CHAIN I AND RESID 91:102 )	I	91 - 102
70	X-RAY DIFFRACTION	70	( CHAIN J AND RESID 17:27 )	J	17 - 27
71	X-RAY DIFFRACTION	71	( CHAIN J AND RESID 28:38 )	J	28 - 38
72	X-RAY DIFFRACTION	72	( CHAIN J AND RESID 39:46 )	J	39 - 46
73	X-RAY DIFFRACTION	73	( CHAIN J AND RESID 47:58 )	J	47 - 58
74	X-RAY DIFFRACTION	74	( CHAIN J AND RESID 59:96 )	J	59 - 96
75	X-RAY DIFFRACTION	75	( CHAIN J AND RESID 97:112 )	J	97 - 112
76	X-RAY DIFFRACTION	76	( CHAIN K AND RESID 61:157 )	K	61 - 157
77	X-RAY DIFFRACTION	77	( CHAIN K AND RESID 158:206 )	K	158 - 206
78	X-RAY DIFFRACTION	78	( CHAIN L AND RESID 60:68 )	L	60 - 68
79	X-RAY DIFFRACTION	79	( CHAIN L AND RESID 69:75 )	L	69 - 75
80	X-RAY DIFFRACTION	80	( CHAIN L AND RESID 76:84 )	L	76 - 84
81	X-RAY DIFFRACTION	81	( CHAIN L AND RESID 85:106 )	L	85 - 106
82	X-RAY DIFFRACTION	82	( CHAIN L AND RESID 107:121 )	L	107 - 121
83	X-RAY DIFFRACTION	83	( CHAIN L AND RESID 122:144 )	L	122 - 144
84	X-RAY DIFFRACTION	84	( CHAIN L AND RESID 145:168 )	L	145 - 168
85	X-RAY DIFFRACTION	85	( CHAIN M AND RESID 1:9 )	M	1 - 9
86	X-RAY DIFFRACTION	86	( CHAIN M AND RESID 10:23 )	M	10 - 23
87	X-RAY DIFFRACTION	87	( CHAIN M AND RESID 24:35 )	M	24 - 35
88	X-RAY DIFFRACTION	88	( CHAIN M AND RESID 36:45 )	M	36 - 45
89	X-RAY DIFFRACTION	89	( CHAIN M AND RESID 46:65 )	M	46 - 65
90	X-RAY DIFFRACTION	90	( CHAIN M AND RESID 66:70 )	M	66 - 70
91	X-RAY DIFFRACTION	91	( CHAIN M AND RESID 71:75 )	M	71 - 75
92	X-RAY DIFFRACTION	92	( CHAIN M AND RESID 76:80 )	M	76 - 80
93	X-RAY DIFFRACTION	93	( CHAIN M AND RESID 81:85 )	M	81 - 85
94	X-RAY DIFFRACTION	94	( CHAIN M AND RESID 86:90 )	M	86 - 90
95	X-RAY DIFFRACTION	95	( CHAIN M AND RESID 91:102 )	M	91 - 102
96	X-RAY DIFFRACTION	96	( CHAIN N AND RESID 17:27 )	N	17 - 27
97	X-RAY DIFFRACTION	97	( CHAIN N AND RESID 28:45 )	N	28 - 45
98	X-RAY DIFFRACTION	98	( CHAIN N AND RESID 46:66 )	N	46 - 66
99	X-RAY DIFFRACTION	99	( CHAIN N AND RESID 67:99 )	N	67 - 99
100	X-RAY DIFFRACTION	100	( CHAIN N AND RESID 100:112 )	N	100 - 112
101	X-RAY DIFFRACTION	101	( CHAIN O AND RESID 61:151 )	O	61 - 151
102	X-RAY DIFFRACTION	102	( CHAIN O AND RESID 152:181 )	O	152 - 181
103	X-RAY DIFFRACTION	103	( CHAIN O AND RESID 182:206 )	O	182 - 206
104	X-RAY DIFFRACTION	104	( CHAIN P AND RESID 60:68 )	P	60 - 68
105	X-RAY DIFFRACTION	105	( CHAIN P AND RESID 69:75 )	P	69 - 75
106	X-RAY DIFFRACTION	106	( CHAIN P AND RESID 76:107 )	P	76 - 107
107	X-RAY DIFFRACTION	107	( CHAIN P AND RESID 108:121 )	P	108 - 121
108	X-RAY DIFFRACTION	108	( CHAIN P AND RESID 122:145 )	P	122 - 145
109	X-RAY DIFFRACTION	109	( CHAIN P AND RESID 146:168 )	P	146 - 168
110	X-RAY DIFFRACTION	110	( CHAIN Q AND RESID 1:23 )	Q	1 - 23
111	X-RAY DIFFRACTION	111	( CHAIN Q AND RESID 24:35 )	Q	24 - 35
112	X-RAY DIFFRACTION	112	( CHAIN Q AND RESID 36:61 )	Q	36 - 61
113	X-RAY DIFFRACTION	113	( CHAIN Q AND RESID 62:71 )	Q	62 - 71
114	X-RAY DIFFRACTION	114	( CHAIN Q AND RESID 72:91 )	Q	72 - 91
115	X-RAY DIFFRACTION	115	( CHAIN Q AND RESID 92:102 )	Q	92 - 102
116	X-RAY DIFFRACTION	116	( CHAIN R AND RESID 17:22 )	R	17 - 22
117	X-RAY DIFFRACTION	117	( CHAIN R AND RESID 23:27 )	R	23 - 27
118	X-RAY DIFFRACTION	118	( CHAIN R AND RESID 28:38 )	R	28 - 38
119	X-RAY DIFFRACTION	119	( CHAIN R AND RESID 39:45 )	R	39 - 45
120	X-RAY DIFFRACTION	120	( CHAIN R AND RESID 46:58 )	R	46 - 58
121	X-RAY DIFFRACTION	121	( CHAIN R AND RESID 59:66 )	R	59 - 66
122	X-RAY DIFFRACTION	122	( CHAIN R AND RESID 67:82 )	R	67 - 82
123	X-RAY DIFFRACTION	123	( CHAIN R AND RESID 83:87 )	R	83 - 87
124	X-RAY DIFFRACTION	124	( CHAIN R AND RESID 88:92 )	R	88 - 92
125	X-RAY DIFFRACTION	125	( CHAIN R AND RESID 93:101 )	R	93 - 101
126	X-RAY DIFFRACTION	126	( CHAIN R AND RESID 102:112 )	R	102 - 112
127	X-RAY DIFFRACTION	127	( CHAIN S AND RESID 61:73 )	S	61 - 73
128	X-RAY DIFFRACTION	128	( CHAIN S AND RESID 74:84 )	S	74 - 84
129	X-RAY DIFFRACTION	129	( CHAIN S AND RESID 85:105 )	S	85 - 105
130	X-RAY DIFFRACTION	130	( CHAIN S AND RESID 106:116 )	S	106 - 116
131	X-RAY DIFFRACTION	131	( CHAIN S AND RESID 117:125 )	S	117 - 125
132	X-RAY DIFFRACTION	132	( CHAIN S AND RESID 126:135 )	S	126 - 135
133	X-RAY DIFFRACTION	133	( CHAIN S AND RESID 136:145 )	S	136 - 145
134	X-RAY DIFFRACTION	134	( CHAIN S AND RESID 146:157 )	S	146 - 157
135	X-RAY DIFFRACTION	135	( CHAIN S AND RESID 158:169 )	S	158 - 169
136	X-RAY DIFFRACTION	136	( CHAIN S AND RESID 170:179 )	S	170 - 179
137	X-RAY DIFFRACTION	137	( CHAIN S AND RESID 180:193 )	S	180 - 193
138	X-RAY DIFFRACTION	138	( CHAIN S AND RESID 194:206 )	S	194 - 206
139	X-RAY DIFFRACTION	139	( CHAIN T AND RESID 60:88 )	T	60 - 88
140	X-RAY DIFFRACTION	140	( CHAIN T AND RESID 89:106 )	T	89 - 106
141	X-RAY DIFFRACTION	141	( CHAIN T AND RESID 107:140 )	T	107 - 140
142	X-RAY DIFFRACTION	142	( CHAIN T AND RESID 141:168 )	T	141 - 168
143	X-RAY DIFFRACTION	143	( CHAIN U AND RESID 1:16 )	U	1 - 16
144	X-RAY DIFFRACTION	144	( CHAIN U AND RESID 17:34 )	U	17 - 34
145	X-RAY DIFFRACTION	145	( CHAIN U AND RESID 35:64 )	U	35 - 64
146	X-RAY DIFFRACTION	146	( CHAIN U AND RESID 65:81 )	U	65 - 81
147	X-RAY DIFFRACTION	147	( CHAIN U AND RESID 82:96 )	U	82 - 96
148	X-RAY DIFFRACTION	148	( CHAIN U AND RESID 97:102 )	U	97 - 102
149	X-RAY DIFFRACTION	149	( CHAIN V AND RESID 17:22 )	V	17 - 22
150	X-RAY DIFFRACTION	150	( CHAIN V AND RESID 23:27 )	V	23 - 27
151	X-RAY DIFFRACTION	151	( CHAIN V AND RESID 28:45 )	V	28 - 45
152	X-RAY DIFFRACTION	152	( CHAIN V AND RESID 46:58 )	V	46 - 58
153	X-RAY DIFFRACTION	153	( CHAIN V AND RESID 59:66 )	V	59 - 66
154	X-RAY DIFFRACTION	154	( CHAIN V AND RESID 67:82 )	V	67 - 82
155	X-RAY DIFFRACTION	155	( CHAIN V AND RESID 83:96 )	V	83 - 96
156	X-RAY DIFFRACTION	156	( CHAIN V AND RESID 97:112 )	V	97 - 112
157	X-RAY DIFFRACTION	157	( CHAIN W AND RESID 61:70 )	W	61 - 70
158	X-RAY DIFFRACTION	158	( CHAIN W AND RESID 71:79 )	W	71 - 79
159	X-RAY DIFFRACTION	159	( CHAIN W AND RESID 80:106 )	W	80 - 106
160	X-RAY DIFFRACTION	160	( CHAIN W AND RESID 107:121 )	W	107 - 121
161	X-RAY DIFFRACTION	161	( CHAIN W AND RESID 122:141 )	W	122 - 141
162	X-RAY DIFFRACTION	162	( CHAIN W AND RESID 142:152 )	W	142 - 152
163	X-RAY DIFFRACTION	163	( CHAIN W AND RESID 153:167 )	W	153 - 167
164	X-RAY DIFFRACTION	164	( CHAIN W AND RESID 168:181 )	W	168 - 181
165	X-RAY DIFFRACTION	165	( CHAIN W AND RESID 182:194 )	W	182 - 194
166	X-RAY DIFFRACTION	166	( CHAIN W AND RESID 195:206 )	W	195 - 206
167	X-RAY DIFFRACTION	167	( CHAIN X AND RESID 60:68 )	X	60 - 68
168	X-RAY DIFFRACTION	168	( CHAIN X AND RESID 69:88 )	X	69 - 88
169	X-RAY DIFFRACTION	169	( CHAIN X AND RESID 89:94 )	X	89 - 94
170	X-RAY DIFFRACTION	170	( CHAIN X AND RESID 95:100 )	X	95 - 100
171	X-RAY DIFFRACTION	171	( CHAIN X AND RESID 101:121 )	X	101 - 121
172	X-RAY DIFFRACTION	172	( CHAIN X AND RESID 122:139 )	X	122 - 139
173	X-RAY DIFFRACTION	173	( CHAIN X AND RESID 140:144 )	X	140 - 144
174	X-RAY DIFFRACTION	174	( CHAIN X AND RESID 145:168 )	X	145 - 168