PDB-8ewv: DNA-encoded library (DEL)-enabled discovery of proximity inducing...

Basic information

• Entry: Database: PDB / ID: 8ewv
• Title: DNA-encoded library (DEL)-enabled discovery of proximity inducing small molecules

Components

• Bromodomain-containing protein 4
• Elongin-B
• Elongin-C
• von Hippel-Lindau disease tumor suppressor

• Keywords: APOPTOSIS / molecular glue / bifunctional compound / BRD4 / VCB / DNA-encoded libraries

Function / homology

Function:

regulation of cellular response to hypoxia / RHOBTB3 ATPase cycle / negative regulation of receptor signaling pathway via JAK-STAT / transcription elongation factor activity / target-directed miRNA degradation / elongin complex / VCB complex / Replication of the SARS-CoV-1 genome / Cul5-RING ubiquitin ligase complex / Cul2-RING ubiquitin ligase complex / intracellular non-membrane-bounded organelle / SUMOylation of ubiquitinylation proteins / negative regulation of transcription elongation by RNA polymerase II / Pausing and recovery of Tat-mediated HIV elongation / Tat-mediated HIV elongation arrest and recovery / RNA polymerase II C-terminal domain binding / HIV elongation arrest and recovery / Pausing and recovery of HIV elongation / negative regulation of DNA damage checkpoint / P-TEFb complex binding / ubiquitin-like ligase-substrate adaptor activity / negative regulation by host of viral transcription / Tat-mediated elongation of the HIV-1 transcript / Formation of HIV-1 elongation complex containing HIV-1 Tat / Formation of HIV elongation complex in the absence of HIV Tat / negative regulation of signal transduction / positive regulation of T-helper 17 cell lineage commitment / RNA Polymerase II Transcription Elongation / Formation of RNA Pol II elongation complex / negative regulation of TORC1 signaling / RNA Polymerase II Pre-transcription Events / positive regulation of G2/M transition of mitotic cell cycle / histone reader activity / negative regulation of autophagy / RNA polymerase II CTD heptapeptide repeat kinase activity / transcription corepressor binding / condensed nuclear chromosome / transcription elongation by RNA polymerase II / positive regulation of cell differentiation / TP53 Regulates Transcription of DNA Repair Genes / transcription initiation at RNA polymerase II promoter / positive regulation of transcription elongation by RNA polymerase II / transcription coregulator activity / Vif-mediated degradation of APOBEC3G / lysine-acetylated histone binding / Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha / cell morphogenesis / Inactivation of CSF3 (G-CSF) signaling / Evasion by RSV of host interferon responses / Regulation of expression of SLITs and ROBOs / ubiquitin-protein transferase activity / transcription corepressor activity / Antigen processing: Ubiquitination & Proteasome degradation / p53 binding / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / protein-macromolecule adaptor activity / chromosome / Neddylation / Replication of the SARS-CoV-2 genome / regulation of inflammatory response / cellular response to hypoxia / ubiquitin-dependent protein catabolic process / regulation of gene expression / protein-containing complex assembly / proteasome-mediated ubiquitin-dependent protein catabolic process / DNA-binding transcription factor binding / positive regulation of canonical NF-kappaB signal transduction / amyloid fibril formation / Potential therapeutics for SARS / molecular adaptor activity / transcription coactivator activity / protein stabilization / transcription cis-regulatory region binding / protein ubiquitination / chromatin remodeling / negative regulation of cell population proliferation / negative regulation of gene expression / ubiquitin protein ligase binding / DNA damage response / chromatin binding / regulation of DNA-templated transcription / chromatin / regulation of transcription by RNA polymerase II / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / enzyme binding / negative regulation of transcription by RNA polymerase II / endoplasmic reticulum / positive regulation of transcription by RNA polymerase II / mitochondrion / proteolysis / nucleoplasm / nucleus / plasma membrane / cytosol

Domain/homology:

von Hippel-Lindau disease tumour suppressor, beta/alpha domain / von Hippel-Lindau disease tumour suppressor, alpha domain / von Hippel-Lindau disease tumour suppressor, beta domain / VHL superfamily / von Hippel-Lindau disease tumour suppressor, alpha domain superfamily / von Hippel-Lindau disease tumour suppressor, beta domain superfamily / VHL beta domain / VHL box domain / Elongin B / Elongin-C / S-phase kinase-associated protein 1-like / SKP1 component, POZ domain / Skp1 family, tetramerisation domain / Found in Skp1 protein family / Bromodomain protein 4, C-terminal / C-terminal domain of bromodomain protein 4 / NET domain superfamily / NET domain profile. / Brdt, bromodomain, repeat II / Brdt, bromodomain, repeat I / NET domain / Bromodomain extra-terminal - transcription regulation / SKP1/BTB/POZ domain superfamily / Bromodomain, conserved site / Bromodomain signature. / Ubiquitin family / Bromodomain / Ubiquitin homologues / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Ubiquitin domain profile. / Ubiquitin-like domain / Ubiquitin-like domain superfamily

Component:

Chem-X5K / Bromodomain-containing protein 4 / von Hippel-Lindau disease tumor suppressor / Elongin-C / Elongin-B

• Biological species: Homo sapiens (human)
• Method: X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 3.4 Å
• Authors: Schreiber, S.L. / Shu, W. / Ma, X. / Michaud, G. / Bonazzi, S. / Berst, F.

Funding support

United States, 1items

Organization	Grant number	Country
National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS)	R35GM127045	United States

• Citation: Journal: Nat.Chem.Biol. / Year: 2024; Title: DNA-encoded library-enabled discovery of proximity-inducing small molecules.; Authors: Mason, J.W. / Chow, Y.T. / Hudson, L. / Tutter, A. / Michaud, G. / Westphal, M.V. / Shu, W. / Ma, X. / Tan, Z.Y. / Coley, C.W. / Clemons, P.A. / Bonazzi, S. / Berst, F. / Briner, K. / Liu, S. / Zecri, F.J. / Schreiber, S.L.

History

Deposition	Oct 24, 2022	Deposition site: RCSB / Processing site: RCSB
Revision 1.0	Oct 4, 2023	Provider: repository / Type: Initial release
Revision 1.1	Nov 15, 2023	Group: Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year
Revision 1.2	Feb 14, 2024	Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.year / _citation_author.identifier_ORCID

Assembly

Deposited unit

A: Elongin-B

B: Elongin-C

C: von Hippel-Lindau disease tumor suppressor

D: Bromodomain-containing protein 4

E: Elongin-B

F: Elongin-C

G: von Hippel-Lindau disease tumor suppressor

H: Bromodomain-containing protein 4

I: Elongin-B

J: Elongin-C

K: von Hippel-Lindau disease tumor suppressor

L: Bromodomain-containing protein 4

M: Elongin-B

N: Elongin-C

O: von Hippel-Lindau disease tumor suppressor

P: Bromodomain-containing protein 4

Q: Elongin-B

R: Elongin-C

S: von Hippel-Lindau disease tumor suppressor

T: Bromodomain-containing protein 4

U: Elongin-B

V: Elongin-C

W: von Hippel-Lindau disease tumor suppressor

X: Bromodomain-containing protein 4

hetero molecules

Summary:

• 352 kDa, 24 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	352,459	30
Polymers	346,817	24
Non-polymers	5,641	6
Water	0	0

1

A: Elongin-B

B: Elongin-C

C: von Hippel-Lindau disease tumor suppressor

D: Bromodomain-containing protein 4

hetero molecules

Summary:

• defined by author
• Evidence: gel filtration
• 58.7 kDa, 4 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	58,743	5
Polymers	57,803	4
Non-polymers	940	1
Water	0

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

2

E: Elongin-B

F: Elongin-C

G: von Hippel-Lindau disease tumor suppressor

H: Bromodomain-containing protein 4

hetero molecules

Summary:

• defined by author
• 58.7 kDa, 4 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	58,743	5
Polymers	57,803	4
Non-polymers	940	1
Water	0

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

3

I: Elongin-B

J: Elongin-C

K: von Hippel-Lindau disease tumor suppressor

L: Bromodomain-containing protein 4

hetero molecules

Summary:

• defined by author
• 58.7 kDa, 4 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	58,743	5
Polymers	57,803	4
Non-polymers	940	1
Water	0

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

4

M: Elongin-B

N: Elongin-C

O: von Hippel-Lindau disease tumor suppressor

P: Bromodomain-containing protein 4

hetero molecules

Summary:

• defined by author
• 58.7 kDa, 4 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	58,743	5
Polymers	57,803	4
Non-polymers	940	1
Water	0

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

5

Q: Elongin-B

R: Elongin-C

S: von Hippel-Lindau disease tumor suppressor

T: Bromodomain-containing protein 4

hetero molecules

Summary:

• defined by author
• 58.7 kDa, 4 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	58,743	5
Polymers	57,803	4
Non-polymers	940	1
Water	0

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

6

U: Elongin-B

V: Elongin-C

W: von Hippel-Lindau disease tumor suppressor

X: Bromodomain-containing protein 4

hetero molecules

Summary:

• defined by author
• 58.7 kDa, 4 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	58,743	5
Polymers	57,803	4
Non-polymers	940	1
Water	0

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Unit cell

Length a, b, c (Å)	110.485, 164.048, 256.202
Angle α, β, γ (deg.)	90.000, 90.000, 90.000
Int Tables number	19
Space group name H-M	P212121
Space group name Hall	P2ac2ab
Symmetry operation	#1: x,y,z #2: x+1/2,-y+1/2,-z #3: -x,y+1/2,-z+1/2 #4: -x+1/2,-y,z+1/2

Components

#1: Protein

A E I M Q U
Elongin-B / EloB / Elongin 18 kDa subunit / RNA polymerase II transcription factor SIII subunit B / SIII p18 / Transcription elongation factor B polypeptide 2

Details:

Mass: 13147.781 Da / Num. of mol.: 6
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: ELOB, TCEB2 / Production host: Escherichia coli (E. coli) / References: UniProt: Q15370

#2: Protein

B F J N R V
Elongin-C / EloC / Elongin 15 kDa subunit / RNA polymerase II transcription factor SIII subunit C / SIII p15 / Transcription elongation factor B polypeptide 1

Details:

Mass: 10843.420 Da / Num. of mol.: 6
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: ELOC, TCEB1 / Production host: Escherichia coli (E. coli) / References: UniProt: Q15369

#3: Protein

C G K O S W
von Hippel-Lindau disease tumor suppressor / Protein G7 / pVHL

Details:

Mass: 18712.328 Da / Num. of mol.: 6
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: VHL / Production host: Escherichia coli (E. coli) / References: UniProt: P40337

#4: Protein

D H L P T X
Bromodomain-containing protein 4 / Protein HUNK1

Details:

Mass: 15099.380 Da / Num. of mol.: 6
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: BRD4, HUNK1 / Production host: Escherichia coli (E. coli) / References: UniProt: O60885

#5: Chemical

C-501 G-501 K-501 O-501 S-501 W-501
ChemComp-X5K / N-{3-[1-(4-{[3-(cyclopropylamino)-3-oxopropyl](methyl)amino}-6-{methyl[(1,3,5-trimethyl-1H-pyrazol-4-yl)methyl]amino}-1,3,5-triazin-2-yl)piperidin-4-yl]propanoyl}-3-methyl-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide

Details:

Mass: 940.211 Da / Num. of mol.: 6 / Source method: obtained synthetically / Formula: C₄₈H₆₉N₁₃O₅S / Feature type: SUBJECT OF INVESTIGATION

• Has ligand of interest: Y

Experimental details

Experiment

• Experiment: Method: X-RAY DIFFRACTION / Number of used crystals: 1

Sample preparation

• Crystal: Density Matthews: 3.35 ų/Da / Density % sol: 63.25 %
• Crystal grow: Temperature: 300 K / Method: vapor diffusion / Details: 0.2 M NA2MALON, 20 %W/V PEG 3350

Data collection

• Diffraction: Mean temperature: 100 K / Serial crystal experiment: N
• Diffraction source: Source: SYNCHROTRON / Site: ALS / Beamline: 5.0.2 / Wavelength: 0.97903 Å
• Detector: Type: DECTRIS PILATUS 2M / Detector: PIXEL / Date: Jun 4, 2020
• Radiation: Monochromator: M / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
• Radiation wavelength: Wavelength: 0.97903 Å / Relative weight: 1
• Reflection: Resolution: 3.4→49.01 Å / Num. obs: 64886 / % possible obs: 100 % / Redundancy: 25 % / B_iso Wilson estimate: 76.05 Ų / CC_1/2: 0.992 / R_merge(I) obs: 0.772 / R_pim(I) all: 0.155 / R_rim(I) all: 0.788 / Χ²: 1.02 / Net I/σ(I): 5.3
• Reflection shell: Resolution: 3.4→3.48 Å / Redundancy: 24.4 % / R_merge(I) obs: 3.442 / Num. unique obs: 4531 / CC_1/2: 0.343 / R_pim(I) all: 0.71 / R_rim(I) all: 1.3 / Χ²: 1.09 / % possible all: 100

Processing

Software

Name	Version	Classification
PHENIX	1.18.2_3874+SVN	refinement
PHENIX	1.18.2_3874+SVN	refinement
XDS		data reduction
pointless		data scaling
AMoRE		phasing

Refinement

Method to determine structure: MOLECULAR REPLACEMENT
Starting model: 4W91

4w91

Resolution: 3.4→49.01 Å / SU ML: 0.7018 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 38.7978
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2

	Rfactor	Num. reflection	% reflection
Rfree	0.3242	3221	4.99 %
Rwork	0.2804	61388	-
obs	0.2826	64609	99.69 %

• Solvent computation: Shrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
• Displacement parameters: B_iso mean: 90.64 Ų

Refinement step

Cycle: LAST / Resolution: 3.4→49.01 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	21721	0	402	0	22123

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.0077	22673
X-RAY DIFFRACTION	f_angle_d	1.5413	30832
X-RAY DIFFRACTION	f_chiral_restr	0.0889	3400
X-RAY DIFFRACTION	f_plane_restr	0.0107	4143
X-RAY DIFFRACTION	f_dihedral_angle_d	10.5367	3278

LS refinement shell

Resolution (Å)	Rfactor Rfree	Num. reflection Rfree	Rfactor Rwork	Num. reflection Rwork	Refine-ID	% reflection obs (%)
3.4-3.45	0.4644	145	0.4053	2667	X-RAY DIFFRACTION	99.86
3.45-3.5	0.4029	130	0.3829	2600	X-RAY DIFFRACTION	100
3.5-3.56	0.377	153	0.367	2654	X-RAY DIFFRACTION	99.89
3.56-3.62	0.3997	149	0.3683	2617	X-RAY DIFFRACTION	99.75
3.62-3.69	0.4456	147	0.4153	2624	X-RAY DIFFRACTION	99.89
3.69-3.76	0.4314	112	0.3642	2675	X-RAY DIFFRACTION	99.93
3.76-3.84	0.3529	134	0.3315	2638	X-RAY DIFFRACTION	99.86
3.84-3.92	0.418	124	0.3322	2660	X-RAY DIFFRACTION	99.78
3.92-4.01	0.3723	157	0.3401	2617	X-RAY DIFFRACTION	99.71
4.01-4.11	0.3151	135	0.3068	2667	X-RAY DIFFRACTION	99.75
4.11-4.22	0.3269	144	0.2889	2658	X-RAY DIFFRACTION	99.61
4.22-4.35	0.3159	122	0.2622	2634	X-RAY DIFFRACTION	99.6
4.35-4.49	0.3205	145	0.2576	2657	X-RAY DIFFRACTION	99.68
4.49-4.65	0.3075	159	0.2556	2638	X-RAY DIFFRACTION	99.71
4.65-4.83	0.3238	138	0.2608	2698	X-RAY DIFFRACTION	99.79
4.83-5.05	0.2747	118	0.2532	2653	X-RAY DIFFRACTION	99.57
5.05-5.32	0.3523	142	0.2614	2659	X-RAY DIFFRACTION	99.75
5.32-5.65	0.3332	141	0.2617	2692	X-RAY DIFFRACTION	99.79
5.65-6.09	0.2951	134	0.2691	2692	X-RAY DIFFRACTION	99.72
6.09-6.7	0.2592	135	0.2615	2692	X-RAY DIFFRACTION	99.65
6.7-7.67	0.2955	163	0.2407	2710	X-RAY DIFFRACTION	99.93
7.67-9.64	0.2339	154	0.2053	2747	X-RAY DIFFRACTION	99.72
9.65-49.01	0.2648	140	0.2072	2839	X-RAY DIFFRACTION	98.09

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°2)	L12 (°2)	L13 (°2)	L22 (°2)	L23 (°2)	L33 (°2)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å2)	T12 (Å2)	T13 (Å2)	T22 (Å2)	T23 (Å2)	T33 (Å2)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	-0.00165400789773	-0.00756254732941	0.0056410122765	0.0315077767236	-0.0327686896148	0.0295086216377	0.220778429759	0.234377986003	-0.363891222363	-0.280930054443	0.172551319349	0.718441789909	0.0287098352754	-0.117839167076	0.000595245628202	0.833789611878	-0.105435077941	-0.118634694438	0.753782629555	-0.0961116736136	1.10615727205	-34.5347064139	31.1040071716	-46.2114467081
2	0.310316085207	0.0620740181244	-0.0101184836046	0.494021652598	-0.189714585319	0.512314923366	-0.206524330548	0.0175074120866	-0.115543556499	-0.0413499271729	-0.212039267105	0.0934640428442	0.0314006996928	-0.0493449548916	-0.252517755303	0.882052114556	0.2156025883	-0.194233569242	0.115506551473	-0.262563573448	0.627927077348	-32.751509688	30.6905095275	-40.8864334798
3	-0.0103589424675	-0.00298231962565	0.00126337890404	0.0102845728911	-0.00947861655545	0.00799804628635	-0.0487029628175	-0.370284098355	0.255472876373	0.0678075512353	-0.284508823403	0.318300466089	-0.121886973171	0.0936984141735	8.02665585345E-5	0.868566817141	0.114911226516	-0.0581746958171	0.876180944678	-0.0178128269824	1.00902638083	-40.4991691529	39.5429823908	-38.5504367742
4	0.00471150764775	0.00470510444363	-0.00287426403071	-0.00171609836967	0.0020416350143	0.00343419730646	-0.110640206176	0.0238373164731	0.127605185635	-0.121783604698	-0.0893580930595	-0.185752034057	-0.00620183944486	0.0326546749388	-0.000224620245274	0.672319371188	-0.2191753898	-0.111455024493	0.500799065031	-0.12606465242	1.13395469794	-29.7126919237	43.9905382782	-46.2359567356
5	0.00954108506419	0.00432837945545	0.0012237416935	0.00289304132861	0.00175873072456	-0.00270896812073	0.0628772113897	-0.0578310319925	0.0969986603616	-0.0592601384638	0.021053968097	0.0644443670168	-0.0112853853603	0.0265395669636	-7.6866722571E-5	0.916129996051	0.113731178061	-0.187963013948	0.7799240897	0.0562244074458	0.72767604584	-38.1159627385	39.9418061757	-52.625071414
6	0.00319486383013	-0.00117207938986	0.00200910805763	0.00277967810085	-8.89389645025E-5	0.0010672860654	-0.041822192599	-0.0172147653404	0.00375882849791	-0.000581184540242	0.0154715722557	0.0566408952246	0.00480528775453	-0.0570922511159	8.35922563746E-5	1.12189828766	-0.292724364226	-0.0681769060768	1.18003104072	0.0908948362272	1.02948472046	-32.0212406106	26.0872296819	-53.3043069133
7	0.0113917515274	-0.000858700142847	-0.0210861224996	0.00795235049413	0.016064715808	0.0666392875897	0.0496487937702	-0.0238827667198	0.183236792745	0.0251284410999	0.0846110658171	0.0821478451274	-0.0232275009857	-0.0135500694546	0.0129707589414	0.98377573883	0.54650920821	-0.174995937262	0.478252233996	-0.105118238283	0.921134627537	-30.0520422772	37.3727160333	-43.7623689905
8	0.00205827985857	-0.00230310344916	-0.0013965657289	0.00111279857515	0.00287464670694	0.00104210571515	-0.0325888482692	0.0126512881683	0.0560475405146	0.122539105747	-0.0309947264953	-0.0393763778521	-0.0697760601838	-0.00572174372314	-0.000152425238541	1.71806281537	-0.470636887013	-0.329440536504	1.52167604732	0.163351005253	1.40964002507	-28.5474238237	48.0438471362	-33.2798381153
9	0.0151566323729	-0.0166211114938	-1.91316629869E-6	0.028215129448	-0.000456712689532	0.000165002501694	0.0931357176044	0.0092835351815	-0.0385792604105	0.106977725753	0.05712187465	0.0469021133469	0.0524375354687	-0.0727124166925	0.000131189174779	0.954323345717	0.0934677230132	0.0993521518163	0.949255795336	-0.0692239849821	0.844846838813	-19.4096530401	34.0698174145	-40.201922652
10	0.113799920255	0.0352404543481	-0.136503851007	0.0125811614328	-0.0453106458299	0.164614971591	-0.122769995889	0.189742489494	-0.316494135849	-0.00052300729852	-0.114976770066	-0.203388881446	0.195342815226	0.208064199716	-0.0140996808822	1.05853651875	-0.102416546822	-0.155367539002	1.04040125267	0.236041763444	1.00996774061	-9.32041502959	18.2390936284	-49.4748380552
11	0.451606615529	0.0732451049528	-0.239789199448	0.203570100047	-0.259646108855	0.376134374079	-0.0698375432193	0.10553744023	-0.0119045203221	0.0171587505726	-0.410583962362	0.362969204021	-0.141509745171	0.230187154099	-0.29855330965	0.343401093612	-0.270450803974	-0.259374149325	0.660867918391	-0.0453050239996	0.612909054449	-28.3870736605	24.6554109634	-33.7972417218
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158	0.0104432724351	-0.00333241224278	-0.0095469470443	0.0518951442421	-0.0141633312336	0.0274362979844	0.0149350122702	-0.0963466723693	0.212725442906	-0.10996093928	-0.00407618522017	-0.112487966008	0.0853084998341	-0.0440549121355	0.0576160065147	0.982948756586	-0.105238334075	-0.120628973271	0.956321428325	-0.04003590645	0.298547512832	-78.1321322837	-3.26931312598	-121.222701482
159	0.0947312923996	-0.0557262260029	-0.0604137093245	0.0287668793822	0.0463731550512	0.0702244053979	0.0348203309882	-0.018676344116	0.201669273534	0.18067740794	0.139238059567	0.200707261142	-0.112193526614	0.446348479324	-4.41177097384E-5	0.428066949979	-0.0458445001686	0.0398192708028	0.753062570075	0.0665964932821	0.423100009892	-69.9696456299	-0.970939712123	-128.94360284
160	-0.0289343514083	-0.020850494457	0.00159196825185	0.0227194621553	-0.0291707304449	0.0410802283741	-0.0881045251817	-0.46283691182	-0.0392282412592	-0.0653354435234	-0.153805306613	0.00131927215724	-0.212140005266	-0.0420035888341	-0.000122371088383	0.942126901815	-0.166627633045	-0.120828088314	0.705182667861	0.00223973083231	0.532816223097	-74.1207320389	2.38292409485	-124.038153373
161	0.80288487773	0.154936298959	-0.206900374451	0.926112665041	0.637639276466	0.567259084962	-0.251381814384	-0.0813969247638	0.220482815296	-0.0243195489935	-0.424809031758	-0.099395382626	0.374227342198	-0.300227724485	-0.606191323537	0.561804750575	-0.0584942011146	0.0148076464401	1.05116191292	0.368766969947	0.457646437518	-78.8599659564	0.684784240411	-130.942817081
162	0.0253186646203	0.00307541786462	0.0613128318175	0.199898570985	0.0572255953047	0.140365513539	0.344472094316	-0.212953763643	0.121445375613	0.232293076007	0.158067964131	0.210537915721	-0.133333141178	-0.119851992965	0.000922670035932	0.482712276284	-0.188792196042	0.0619895588228	1.04495249549	0.0987064259215	0.404512457074	-83.1981785462	-1.27623657707	-119.504351724
163	0.0180256458748	0.00747628809678	0.000480848239015	-0.000727646972025	-3.44539967095E-5	5.84848647183E-5	0.0656269463721	-0.179867543331	0.076232029696	-0.103434315811	0.159281454077	0.0466205712264	0.146092319065	0.0948920228821	-0.000107068303702	0.332212022314	-0.0731997952091	-0.0027471893089	0.66316962293	0.070667386387	0.31945327244	-77.2903627191	-9.43488454071	-146.389448689
164	0.139333445814	0.0448509860268	0.180296865	0.0166211175192	0.0621169914045	0.2314108373	-0.0248660955477	-0.355362331116	-0.0361707977469	0.0744690002702	-0.129479111388	-0.163725475572	0.118010196347	0.186531234706	-0.0126714441483	0.463870132031	-0.288044041827	-0.109661155269	1.25809715226	0.276256172995	0.706317437203	-64.7393114851	-11.1984551684	-155.934638275
165	0.00572713044407	0.0237585198692	0.000122198483878	0.0340992501563	0.016739383944	0.00890418889262	0.121654453531	-0.188649445523	-0.243555935539	-0.269158432629	-0.0756435453293	-0.0621729493163	-0.0833481866648	0.063377516441	0.000429482151714	0.853749801757	-0.142579112778	0.0407425361778	0.501198724036	-0.0681071714619	0.448155396383	-69.9361297575	-2.56252325251	-153.231975222
166	1.07814800764	1.36915110295	0.247455084301	1.7628750847	0.306807658272	0.066435887598	0.134037084288	-0.266099099349	0.0938443769637	-0.0179635625861	-0.152934700911	0.205079884916	-0.309083613404	-0.175366782549	-0.0188797399526	1.49481913628	-0.135636235883	-0.190053436605	1.38222361347	0.0565466982623	-0.0324285806228	-77.2401523106	9.98137004094	-141.075802783
167	0.0459992467322	0.0290672649495	-0.0114104568059	0.0276904754953	-0.00409451984579	0.00417647502949	-0.0100734244735	0.00649817836595	-0.0176179975069	0.0219944136408	-0.0503871536729	-0.012055544857	0.0558453845546	0.0372236212192	-0.0164095516563	1.73373117907	-0.336269908514	0.100787425746	1.3259397409	0.601249527669	0.92600793809	-45.1691051717	28.8078789971	-125.121913924
168	0.00356738765882	0.00718497939542	0.00216282577508	0.000434564962458	0.0103761155133	0.0115796276414	0.0446951364241	0.255216384842	-0.223766813566	0.0593063034193	0.148180904895	0.213026516715	-0.0233485375709	0.301080663304	-0.000102748270581	1.47921043532	-0.247968147252	0.103496688567	1.44157717982	-0.231444125836	1.0044866461	-60.884599323	20.8447712409	-121.422765798
169	0.00392923952912	-0.00689412246337	0.00504799738266	0.0101862370951	-0.00867441801419	0.0101193197436	-0.0625920211895	-0.0320014802922	0.0189783847748	-0.0523085484491	-0.0541349672185	0.0572332353856	-0.00671096356637	-0.0412730628066	7.81847163716E-5	1.64328867531	0.268944952979	-0.0629002228635	1.37610278714	0.0950582140643	0.613746033725	-73.6904297467	22.7339242672	-106.609520669
170	0.00555760890808	-0.00345798656953	-0.00645958968878	0.00215338638374	0.00364312893755	0.00487591166203	0.0630865978655	0.0104369991935	0.0370891158611	0.0721895596946	0.123667053151	0.13241899731	0.00434676827032	-0.0981209959735	0.000292325076334	1.33952544307	0.0922907711525	0.132559513518	1.14783120507	-0.524358456715	1.05602984996	-65.6855690105	22.4785128547	-100.644259595
171	-0.00371268377993	0.0147879715358	-0.00670769062191	0.0154400228457	-0.0165920267585	0.0203282738738	-0.0743882614304	0.234781442071	0.389721595678	-0.295027792425	0.0553743050407	0.0780093597655	-0.081569216729	0.277672889315	0.000128252406062	1.98577106439	-0.733816236523	-0.28781096526	1.24344626302	0.0698825890597	1.23244965392	-54.2527723289	31.2544961612	-114.584901102
172	0.0771017093206	0.034976400891	0.0544927313774	0.0047418108683	0.0273207809	0.0501416989396	-0.17616606022	0.117261826594	0.0858814203106	-0.178520249267	-0.0656612712679	0.107278235528	-0.210372371989	0.0100791572263	-0.138966438391	1.74776622692	-1.02213684182	0.244404204309	1.24379199942	-0.385860600389	0.517717060778	-52.8193089064	21.2557082779	-110.518499768
173	0.00919377633368	-0.00680967021894	0.00497102123851	0.00905337352516	0.00132321786425	0.0107580666631	0.0391199061383	-0.00317803101144	-0.00806212544459	-0.000496968509959	0.0905719409011	0.0182934869338	0.0221705199678	-0.00740964253371	-0.000736365523586	0.976135483155	0.107825618276	0.359924191073	1.16559969538	-0.0379520488678	0.939622835318	-63.1918220099	8.41406527677	-106.849966441
174	0.603431741548	-0.0682811430543	-0.100146260279	0.99369430844	-0.529290094137	0.3241968538	0.122193479463	-0.0114896582662	0.0240660117817	-0.299521923544	0.281495353187	0.217854624655	0.028517721643	-0.0865110392066	0.348356891239	1.22760528433	-0.804377606743	0.512397954795	0.906709847555	-0.181968462766	0.486945496421	-49.4108131717	15.969209741	-119.734115059

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details	Auth asym-ID	Auth seq-ID
1	X-RAY DIFFRACTION	1	( CHAIN A AND RESID 1:9 )	A	1 - 9
2	X-RAY DIFFRACTION	2	( CHAIN A AND RESID 10:19 )	A	10 - 19
3	X-RAY DIFFRACTION	3	( CHAIN A AND RESID 20:42 )	A	20 - 42
4	X-RAY DIFFRACTION	4	( CHAIN A AND RESID 43:50 )	A	43 - 50
5	X-RAY DIFFRACTION	5	( CHAIN A AND RESID 51:65 )	A	51 - 65
6	X-RAY DIFFRACTION	6	( CHAIN A AND RESID 66:72 )	A	66 - 72
7	X-RAY DIFFRACTION	7	( CHAIN A AND RESID 73:78 )	A	73 - 78
8	X-RAY DIFFRACTION	8	( CHAIN A AND RESID 79:88 )	A	79 - 88
9	X-RAY DIFFRACTION	9	( CHAIN A AND RESID 89:93 )	A	89 - 93
10	X-RAY DIFFRACTION	10	( CHAIN A AND RESID 94:102 )	A	94 - 102
11	X-RAY DIFFRACTION	11	( CHAIN B AND RESID 17:27 )	B	17 - 27
12	X-RAY DIFFRACTION	12	( CHAIN B AND RESID 28:45 )	B	28 - 45
13	X-RAY DIFFRACTION	13	( CHAIN B AND RESID 46:58 )	B	46 - 58
14	X-RAY DIFFRACTION	14	( CHAIN B AND RESID 59:66 )	B	59 - 66
15	X-RAY DIFFRACTION	15	( CHAIN B AND RESID 67:82 )	B	67 - 82
16	X-RAY DIFFRACTION	16	( CHAIN B AND RESID 83:96 )	B	83 - 96
17	X-RAY DIFFRACTION	17	( CHAIN B AND RESID 97:112 )	B	97 - 112
18	X-RAY DIFFRACTION	18	( CHAIN C AND RESID 61:70 )	C	61 - 70
19	X-RAY DIFFRACTION	19	( CHAIN C AND RESID 71:83 )	C	71 - 83
20	X-RAY DIFFRACTION	20	( CHAIN C AND RESID 84:94 )	C	84 - 94
21	X-RAY DIFFRACTION	21	( CHAIN C AND RESID 95:115 )	C	95 - 115
22	X-RAY DIFFRACTION	22	( CHAIN C AND RESID 116:131 )	C	116 - 131
23	X-RAY DIFFRACTION	23	( CHAIN C AND RESID 132:141 )	C	132 - 141
24	X-RAY DIFFRACTION	24	( CHAIN C AND RESID 142:157 )	C	142 - 157
25	X-RAY DIFFRACTION	25	( CHAIN C AND RESID 158:184 )	C	158 - 184
26	X-RAY DIFFRACTION	26	( CHAIN C AND RESID 185:193 )	C	185 - 193
27	X-RAY DIFFRACTION	27	( CHAIN C AND RESID 194:206 )	C	194 - 206
28	X-RAY DIFFRACTION	28	( CHAIN D AND RESID 60:88 )	D	60 - 88
29	X-RAY DIFFRACTION	29	( CHAIN D AND RESID 89:123 )	D	89 - 123
30	X-RAY DIFFRACTION	30	( CHAIN D AND RESID 124:139 )	D	124 - 139
31	X-RAY DIFFRACTION	31	( CHAIN D AND RESID 140:168 )	D	140 - 168
32	X-RAY DIFFRACTION	32	( CHAIN E AND RESID 1:9 )	E	1 - 9
33	X-RAY DIFFRACTION	33	( CHAIN E AND RESID 10:23 )	E	10 - 23
34	X-RAY DIFFRACTION	34	( CHAIN E AND RESID 24:35 )	E	24 - 35
35	X-RAY DIFFRACTION	35	( CHAIN E AND RESID 36:46 )	E	36 - 46
36	X-RAY DIFFRACTION	36	( CHAIN E AND RESID 47:60 )	E	47 - 60
37	X-RAY DIFFRACTION	37	( CHAIN E AND RESID 61:72 )	E	61 - 72
38	X-RAY DIFFRACTION	38	( CHAIN E AND RESID 73:80 )	E	73 - 80
39	X-RAY DIFFRACTION	39	( CHAIN E AND RESID 81:85 )	E	81 - 85
40	X-RAY DIFFRACTION	40	( CHAIN E AND RESID 86:90 )	E	86 - 90
41	X-RAY DIFFRACTION	41	( CHAIN E AND RESID 91:95 )	E	91 - 95
42	X-RAY DIFFRACTION	42	( CHAIN E AND RESID 96:102 )	E	96 - 102
43	X-RAY DIFFRACTION	43	( CHAIN F AND RESID 17:45 )	F	17 - 45
44	X-RAY DIFFRACTION	44	( CHAIN F AND RESID 46:58 )	F	46 - 58
45	X-RAY DIFFRACTION	45	( CHAIN F AND RESID 59:66 )	F	59 - 66
46	X-RAY DIFFRACTION	46	( CHAIN F AND RESID 67:83 )	F	67 - 83
47	X-RAY DIFFRACTION	47	( CHAIN F AND RESID 84:96 )	F	84 - 96
48	X-RAY DIFFRACTION	48	( CHAIN F AND RESID 97:112 )	F	97 - 112
49	X-RAY DIFFRACTION	49	( CHAIN G AND RESID 61:70 )	G	61 - 70
50	X-RAY DIFFRACTION	50	( CHAIN G AND RESID 71:105 )	G	71 - 105
51	X-RAY DIFFRACTION	51	( CHAIN G AND RESID 106:118 )	G	106 - 118
52	X-RAY DIFFRACTION	52	( CHAIN G AND RESID 119:128 )	G	119 - 128
53	X-RAY DIFFRACTION	53	( CHAIN G AND RESID 129:137 )	G	129 - 137
54	X-RAY DIFFRACTION	54	( CHAIN G AND RESID 138:146 )	G	138 - 146
55	X-RAY DIFFRACTION	55	( CHAIN G AND RESID 147:169 )	G	147 - 169
56	X-RAY DIFFRACTION	56	( CHAIN G AND RESID 170:181 )	G	170 - 181
57	X-RAY DIFFRACTION	57	( CHAIN G AND RESID 182:195 )	G	182 - 195
58	X-RAY DIFFRACTION	58	( CHAIN G AND RESID 196:206 )	G	196 - 206
59	X-RAY DIFFRACTION	59	( CHAIN H AND RESID 60:68 )	H	60 - 68
60	X-RAY DIFFRACTION	60	( CHAIN H AND RESID 69:84 )	H	69 - 84
61	X-RAY DIFFRACTION	61	( CHAIN H AND RESID 85:100 )	H	85 - 100
62	X-RAY DIFFRACTION	62	( CHAIN H AND RESID 101:139 )	H	101 - 139
63	X-RAY DIFFRACTION	63	( CHAIN H AND RESID 140:161 )	H	140 - 161
64	X-RAY DIFFRACTION	64	( CHAIN H AND RESID 162:168 )	H	162 - 168
65	X-RAY DIFFRACTION	65	( CHAIN I AND RESID 1:33 )	I	1 - 33
66	X-RAY DIFFRACTION	66	( CHAIN I AND RESID 34:51 )	I	34 - 51
67	X-RAY DIFFRACTION	67	( CHAIN I AND RESID 52:72 )	I	52 - 72
68	X-RAY DIFFRACTION	68	( CHAIN I AND RESID 73:90 )	I	73 - 90
69	X-RAY DIFFRACTION	69	( CHAIN I AND RESID 91:102 )	I	91 - 102
70	X-RAY DIFFRACTION	70	( CHAIN J AND RESID 17:27 )	J	17 - 27
71	X-RAY DIFFRACTION	71	( CHAIN J AND RESID 28:38 )	J	28 - 38
72	X-RAY DIFFRACTION	72	( CHAIN J AND RESID 39:46 )	J	39 - 46
73	X-RAY DIFFRACTION	73	( CHAIN J AND RESID 47:58 )	J	47 - 58
74	X-RAY DIFFRACTION	74	( CHAIN J AND RESID 59:96 )	J	59 - 96
75	X-RAY DIFFRACTION	75	( CHAIN J AND RESID 97:112 )	J	97 - 112
76	X-RAY DIFFRACTION	76	( CHAIN K AND RESID 61:157 )	K	61 - 157
77	X-RAY DIFFRACTION	77	( CHAIN K AND RESID 158:206 )	K	158 - 206
78	X-RAY DIFFRACTION	78	( CHAIN L AND RESID 60:68 )	L	60 - 68
79	X-RAY DIFFRACTION	79	( CHAIN L AND RESID 69:75 )	L	69 - 75
80	X-RAY DIFFRACTION	80	( CHAIN L AND RESID 76:84 )	L	76 - 84
81	X-RAY DIFFRACTION	81	( CHAIN L AND RESID 85:106 )	L	85 - 106
82	X-RAY DIFFRACTION	82	( CHAIN L AND RESID 107:121 )	L	107 - 121
83	X-RAY DIFFRACTION	83	( CHAIN L AND RESID 122:144 )	L	122 - 144
84	X-RAY DIFFRACTION	84	( CHAIN L AND RESID 145:168 )	L	145 - 168
85	X-RAY DIFFRACTION	85	( CHAIN M AND RESID 1:9 )	M	1 - 9
86	X-RAY DIFFRACTION	86	( CHAIN M AND RESID 10:23 )	M	10 - 23
87	X-RAY DIFFRACTION	87	( CHAIN M AND RESID 24:35 )	M	24 - 35
88	X-RAY DIFFRACTION	88	( CHAIN M AND RESID 36:45 )	M	36 - 45
89	X-RAY DIFFRACTION	89	( CHAIN M AND RESID 46:65 )	M	46 - 65
90	X-RAY DIFFRACTION	90	( CHAIN M AND RESID 66:70 )	M	66 - 70
91	X-RAY DIFFRACTION	91	( CHAIN M AND RESID 71:75 )	M	71 - 75
92	X-RAY DIFFRACTION	92	( CHAIN M AND RESID 76:80 )	M	76 - 80
93	X-RAY DIFFRACTION	93	( CHAIN M AND RESID 81:85 )	M	81 - 85
94	X-RAY DIFFRACTION	94	( CHAIN M AND RESID 86:90 )	M	86 - 90
95	X-RAY DIFFRACTION	95	( CHAIN M AND RESID 91:102 )	M	91 - 102
96	X-RAY DIFFRACTION	96	( CHAIN N AND RESID 17:27 )	N	17 - 27
97	X-RAY DIFFRACTION	97	( CHAIN N AND RESID 28:45 )	N	28 - 45
98	X-RAY DIFFRACTION	98	( CHAIN N AND RESID 46:66 )	N	46 - 66
99	X-RAY DIFFRACTION	99	( CHAIN N AND RESID 67:99 )	N	67 - 99
100	X-RAY DIFFRACTION	100	( CHAIN N AND RESID 100:112 )	N	100 - 112
101	X-RAY DIFFRACTION	101	( CHAIN O AND RESID 61:151 )	O	61 - 151
102	X-RAY DIFFRACTION	102	( CHAIN O AND RESID 152:181 )	O	152 - 181
103	X-RAY DIFFRACTION	103	( CHAIN O AND RESID 182:206 )	O	182 - 206
104	X-RAY DIFFRACTION	104	( CHAIN P AND RESID 60:68 )	P	60 - 68
105	X-RAY DIFFRACTION	105	( CHAIN P AND RESID 69:75 )	P	69 - 75
106	X-RAY DIFFRACTION	106	( CHAIN P AND RESID 76:107 )	P	76 - 107
107	X-RAY DIFFRACTION	107	( CHAIN P AND RESID 108:121 )	P	108 - 121
108	X-RAY DIFFRACTION	108	( CHAIN P AND RESID 122:145 )	P	122 - 145
109	X-RAY DIFFRACTION	109	( CHAIN P AND RESID 146:168 )	P	146 - 168
110	X-RAY DIFFRACTION	110	( CHAIN Q AND RESID 1:23 )	Q	1 - 23
111	X-RAY DIFFRACTION	111	( CHAIN Q AND RESID 24:35 )	Q	24 - 35
112	X-RAY DIFFRACTION	112	( CHAIN Q AND RESID 36:61 )	Q	36 - 61
113	X-RAY DIFFRACTION	113	( CHAIN Q AND RESID 62:71 )	Q	62 - 71
114	X-RAY DIFFRACTION	114	( CHAIN Q AND RESID 72:91 )	Q	72 - 91
115	X-RAY DIFFRACTION	115	( CHAIN Q AND RESID 92:102 )	Q	92 - 102
116	X-RAY DIFFRACTION	116	( CHAIN R AND RESID 17:22 )	R	17 - 22
117	X-RAY DIFFRACTION	117	( CHAIN R AND RESID 23:27 )	R	23 - 27
118	X-RAY DIFFRACTION	118	( CHAIN R AND RESID 28:38 )	R	28 - 38
119	X-RAY DIFFRACTION	119	( CHAIN R AND RESID 39:45 )	R	39 - 45
120	X-RAY DIFFRACTION	120	( CHAIN R AND RESID 46:58 )	R	46 - 58
121	X-RAY DIFFRACTION	121	( CHAIN R AND RESID 59:66 )	R	59 - 66
122	X-RAY DIFFRACTION	122	( CHAIN R AND RESID 67:82 )	R	67 - 82
123	X-RAY DIFFRACTION	123	( CHAIN R AND RESID 83:87 )	R	83 - 87
124	X-RAY DIFFRACTION	124	( CHAIN R AND RESID 88:92 )	R	88 - 92
125	X-RAY DIFFRACTION	125	( CHAIN R AND RESID 93:101 )	R	93 - 101
126	X-RAY DIFFRACTION	126	( CHAIN R AND RESID 102:112 )	R	102 - 112
127	X-RAY DIFFRACTION	127	( CHAIN S AND RESID 61:73 )	S	61 - 73
128	X-RAY DIFFRACTION	128	( CHAIN S AND RESID 74:84 )	S	74 - 84
129	X-RAY DIFFRACTION	129	( CHAIN S AND RESID 85:105 )	S	85 - 105
130	X-RAY DIFFRACTION	130	( CHAIN S AND RESID 106:116 )	S	106 - 116
131	X-RAY DIFFRACTION	131	( CHAIN S AND RESID 117:125 )	S	117 - 125
132	X-RAY DIFFRACTION	132	( CHAIN S AND RESID 126:135 )	S	126 - 135
133	X-RAY DIFFRACTION	133	( CHAIN S AND RESID 136:145 )	S	136 - 145
134	X-RAY DIFFRACTION	134	( CHAIN S AND RESID 146:157 )	S	146 - 157
135	X-RAY DIFFRACTION	135	( CHAIN S AND RESID 158:169 )	S	158 - 169
136	X-RAY DIFFRACTION	136	( CHAIN S AND RESID 170:179 )	S	170 - 179
137	X-RAY DIFFRACTION	137	( CHAIN S AND RESID 180:193 )	S	180 - 193
138	X-RAY DIFFRACTION	138	( CHAIN S AND RESID 194:206 )	S	194 - 206
139	X-RAY DIFFRACTION	139	( CHAIN T AND RESID 60:88 )	T	60 - 88
140	X-RAY DIFFRACTION	140	( CHAIN T AND RESID 89:106 )	T	89 - 106
141	X-RAY DIFFRACTION	141	( CHAIN T AND RESID 107:140 )	T	107 - 140
142	X-RAY DIFFRACTION	142	( CHAIN T AND RESID 141:168 )	T	141 - 168
143	X-RAY DIFFRACTION	143	( CHAIN U AND RESID 1:16 )	U	1 - 16
144	X-RAY DIFFRACTION	144	( CHAIN U AND RESID 17:34 )	U	17 - 34
145	X-RAY DIFFRACTION	145	( CHAIN U AND RESID 35:64 )	U	35 - 64
146	X-RAY DIFFRACTION	146	( CHAIN U AND RESID 65:81 )	U	65 - 81
147	X-RAY DIFFRACTION	147	( CHAIN U AND RESID 82:96 )	U	82 - 96
148	X-RAY DIFFRACTION	148	( CHAIN U AND RESID 97:102 )	U	97 - 102
149	X-RAY DIFFRACTION	149	( CHAIN V AND RESID 17:22 )	V	17 - 22
150	X-RAY DIFFRACTION	150	( CHAIN V AND RESID 23:27 )	V	23 - 27
151	X-RAY DIFFRACTION	151	( CHAIN V AND RESID 28:45 )	V	28 - 45
152	X-RAY DIFFRACTION	152	( CHAIN V AND RESID 46:58 )	V	46 - 58
153	X-RAY DIFFRACTION	153	( CHAIN V AND RESID 59:66 )	V	59 - 66
154	X-RAY DIFFRACTION	154	( CHAIN V AND RESID 67:82 )	V	67 - 82
155	X-RAY DIFFRACTION	155	( CHAIN V AND RESID 83:96 )	V	83 - 96
156	X-RAY DIFFRACTION	156	( CHAIN V AND RESID 97:112 )	V	97 - 112
157	X-RAY DIFFRACTION	157	( CHAIN W AND RESID 61:70 )	W	61 - 70
158	X-RAY DIFFRACTION	158	( CHAIN W AND RESID 71:79 )	W	71 - 79
159	X-RAY DIFFRACTION	159	( CHAIN W AND RESID 80:106 )	W	80 - 106
160	X-RAY DIFFRACTION	160	( CHAIN W AND RESID 107:121 )	W	107 - 121
161	X-RAY DIFFRACTION	161	( CHAIN W AND RESID 122:141 )	W	122 - 141
162	X-RAY DIFFRACTION	162	( CHAIN W AND RESID 142:152 )	W	142 - 152
163	X-RAY DIFFRACTION	163	( CHAIN W AND RESID 153:167 )	W	153 - 167
164	X-RAY DIFFRACTION	164	( CHAIN W AND RESID 168:181 )	W	168 - 181
165	X-RAY DIFFRACTION	165	( CHAIN W AND RESID 182:194 )	W	182 - 194
166	X-RAY DIFFRACTION	166	( CHAIN W AND RESID 195:206 )	W	195 - 206
167	X-RAY DIFFRACTION	167	( CHAIN X AND RESID 60:68 )	X	60 - 68
168	X-RAY DIFFRACTION	168	( CHAIN X AND RESID 69:88 )	X	69 - 88
169	X-RAY DIFFRACTION	169	( CHAIN X AND RESID 89:94 )	X	89 - 94
170	X-RAY DIFFRACTION	170	( CHAIN X AND RESID 95:100 )	X	95 - 100
171	X-RAY DIFFRACTION	171	( CHAIN X AND RESID 101:121 )	X	101 - 121
172	X-RAY DIFFRACTION	172	( CHAIN X AND RESID 122:139 )	X	122 - 139
173	X-RAY DIFFRACTION	173	( CHAIN X AND RESID 140:144 )	X	140 - 144
174	X-RAY DIFFRACTION	174	( CHAIN X AND RESID 145:168 )	X	145 - 168