- PDB-8edh: Identification of a class of WNK isoform-specific inhibitors thro... -
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IDまたはキーワード:
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基本情報
登録情報
データベース: PDB / ID: 8edh
タイトル
Identification of a class of WNK isoform-specific inhibitors through high-throughput screening
要素
Serine/threonine-protein kinase WNK3
キーワード
TRANSFERASE / inhibitor / WNK3 / kinase / complex
機能・相同性
機能・相同性情報
positive regulation of ion transmembrane transporter activity / negative regulation of pancreatic juice secretion / positive regulation of sodium ion transmembrane transporter activity / negative regulation of sodium ion transport / monoatomic ion homeostasis / positive regulation of potassium ion import across plasma membrane / regulation of calcium ion import / positive regulation of sodium ion transport / non-membrane-bounded organelle assembly / potassium channel inhibitor activity ...positive regulation of ion transmembrane transporter activity / negative regulation of pancreatic juice secretion / positive regulation of sodium ion transmembrane transporter activity / negative regulation of sodium ion transport / monoatomic ion homeostasis / positive regulation of potassium ion import across plasma membrane / regulation of calcium ion import / positive regulation of sodium ion transport / non-membrane-bounded organelle assembly / potassium channel inhibitor activity / positive regulation of calcium ion transport / cellular hyperosmotic response / osmosensory signaling pathway / regulation of monoatomic cation transmembrane transport / cell volume homeostasis / negative regulation of protein localization to plasma membrane / maintenance of blood-brain barrier / bicellular tight junction / molecular condensate scaffold activity / positive regulation of peptidyl-threonine phosphorylation / protein localization to plasma membrane / positive regulation of protein localization to plasma membrane / adherens junction / peptidyl-threonine phosphorylation / Stimuli-sensing channels / protein autophosphorylation / non-specific serine/threonine protein kinase / protein kinase activity / intracellular signal transduction / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / negative regulation of apoptotic process / ATP binding / cytoplasm / cytosol 類似検索 - 分子機能
Serine/threonine-protein kinase OSR1/WNK, CCT domain / Oxidative-stress-responsive kinase 1 C-terminal domain / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性
Component-ID: 1 / Ens-ID: 1 / Beg auth comp-ID: ALA / Beg label comp-ID: ALA / End auth comp-ID: ALA / End label comp-ID: ALA / Refine code: 1 / Auth asym-ID: A / Label asym-ID: A / Auth seq-ID: 137 - 406 / Label seq-ID: 20 - 289
Dom-ID
1
2
NCSアンサンブル: (詳細: Local NCS retraints between domains: 1 2)
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要素
#1: タンパク質
Serine/threonine-proteinkinaseWNK3 / Protein kinase lysine-deficient 3 / Protein kinase with no lysine 3
分子量: 33637.930 Da / 分子数: 2 / 変異: S308A / 由来タイプ: 組換発現 / 詳細: Kinase domain of WNK3 with S308A mutation / 由来: (組換発現) Homo sapiens (ヒト) / 遺伝子: WNK3, KIAA1566, PRKWNK3 / 発現宿主: Escherichia coli BL21 (大腸菌) 参照: UniProt: Q9BYP7, non-specific serine/threonine protein kinase