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TitleIdentification of a Class of WNK Isoform-Specific Inhibitors Through High-Throughput Screening.
Journal, issue, pagesDrug Des Devel Ther, Vol. 17, Page 93-105, Year 2023
Publish dateSep 4, 2022 (structure data deposition date)
AuthorsChlebowicz, J. / Akella, R. / Humphreys, J.M. / He, H. / Kannangara, A.R. / Wei, S. / Posner, B. / Goldsmith, E.J.
External linksDrug Des Devel Ther / PubMed:36712947
MethodsX-ray diffraction
Resolution3.111 Å
Structure data

PDB-8edh:
Identification of a class of WNK isoform-specific inhibitors through high-throughput screening
Method: X-RAY DIFFRACTION / Resolution: 3.111 Å

Chemicals

ChemComp-WGK:
ethyl 1-(5,7-dimethoxy-4-methylquinolin-2-yl)piperidine-4-carboxylate

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / inhibitor / WNK3 / kinase / complex

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