- PDB-8edh: Identification of a class of WNK isoform-specific inhibitors thro... -
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Basic information
Entry
Database: PDB / ID: 8edh
Title
Identification of a class of WNK isoform-specific inhibitors through high-throughput screening
Components
Serine/threonine-protein kinase WNK3
Keywords
TRANSFERASE / inhibitor / WNK3 / kinase / complex
Function / homology
Function and homology information
positive regulation of ion transmembrane transporter activity / negative regulation of pancreatic juice secretion / positive regulation of sodium ion transmembrane transporter activity / monoatomic ion homeostasis / negative regulation of sodium ion transport / positive regulation of potassium ion import across plasma membrane / regulation of calcium ion import / positive regulation of sodium ion transport / non-membrane-bounded organelle assembly / potassium channel inhibitor activity ...positive regulation of ion transmembrane transporter activity / negative regulation of pancreatic juice secretion / positive regulation of sodium ion transmembrane transporter activity / monoatomic ion homeostasis / negative regulation of sodium ion transport / positive regulation of potassium ion import across plasma membrane / regulation of calcium ion import / positive regulation of sodium ion transport / non-membrane-bounded organelle assembly / potassium channel inhibitor activity / positive regulation of calcium ion transport / cellular hyperosmotic response / osmosensory signaling pathway / regulation of monoatomic cation transmembrane transport / cell volume homeostasis / negative regulation of protein localization to plasma membrane / maintenance of blood-brain barrier / bicellular tight junction / positive regulation of peptidyl-threonine phosphorylation / molecular condensate scaffold activity / protein localization to plasma membrane / positive regulation of protein localization to plasma membrane / adherens junction / peptidyl-threonine phosphorylation / Stimuli-sensing channels / protein autophosphorylation / non-specific serine/threonine protein kinase / protein kinase activity / intracellular signal transduction / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / negative regulation of apoptotic process / ATP binding / cytoplasm / cytosol Similarity search - Function
Serine/threonine-protein kinase OSR1/WNK, CCT domain / Oxidative-stress-responsive kinase 1 C-terminal domain / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily Similarity search - Domain/homology
Component-ID: 1 / Ens-ID: 1 / Beg auth comp-ID: ALA / Beg label comp-ID: ALA / End auth comp-ID: ALA / End label comp-ID: ALA / Refine code: 1 / Auth asym-ID: A / Label asym-ID: A / Auth seq-ID: 137 - 406 / Label seq-ID: 20 - 289
Dom-ID
1
2
NCS ensembles : (Details: Local NCS retraints between domains: 1 2)
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Components
#1: Protein
Serine/threonine-proteinkinaseWNK3 / Protein kinase lysine-deficient 3 / Protein kinase with no lysine 3
Mass: 33637.930 Da / Num. of mol.: 2 / Mutation: S308A Source method: isolated from a genetically manipulated source Details: Kinase domain of WNK3 with S308A mutation / Source: (gene. exp.) Homo sapiens (human) / Gene: WNK3, KIAA1566, PRKWNK3 / Production host: Escherichia coli BL21 (bacteria) References: UniProt: Q9BYP7, non-specific serine/threonine protein kinase
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