登録情報 データベース : PDB / ID : 8e1a 構造の表示 ダウンロードとリンクタイトル Structure-based study to overcome cross-reactivity of novel androgen receptor inhibitors 要素Androgen receptor 詳細 キーワード TRANSCRIPTION / androgen receptor / agonist / antagonist / HORMONE RECEPTOR機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
male somatic sex determination / activation of prostate induction by androgen receptor signaling pathway / lateral sprouting involved in mammary gland duct morphogenesis / POU domain binding / negative regulation of integrin biosynthetic process / regulation of developmental growth / male genitalia morphogenesis / positive regulation of integrin biosynthetic process / tertiary branching involved in mammary gland duct morphogenesis / animal organ formation ... male somatic sex determination / activation of prostate induction by androgen receptor signaling pathway / lateral sprouting involved in mammary gland duct morphogenesis / POU domain binding / negative regulation of integrin biosynthetic process / regulation of developmental growth / male genitalia morphogenesis / positive regulation of integrin biosynthetic process / tertiary branching involved in mammary gland duct morphogenesis / animal organ formation / androgen binding / Leydig cell differentiation / regulation of systemic arterial blood pressure / epithelial cell morphogenesis / prostate gland growth / epithelial cell differentiation involved in prostate gland development / non-membrane-bounded organelle assembly / positive regulation of epithelial cell proliferation involved in prostate gland development / prostate gland epithelium morphogenesis / intracellular receptor signaling pathway / cellular response to testosterone stimulus / RNA polymerase II general transcription initiation factor binding / positive regulation of insulin-like growth factor receptor signaling pathway / positive regulation of transcription by RNA polymerase III / positive regulation of intracellular estrogen receptor signaling pathway / cellular response to steroid hormone stimulus / morphogenesis of an epithelial fold / seminiferous tubule development / androgen receptor signaling pathway / RUNX2 regulates osteoblast differentiation / single fertilization / mammary gland alveolus development / regulation of protein localization to plasma membrane / estrogen receptor signaling pathway / cellular response to estrogen stimulus / estrogen response element binding / nuclear receptor-mediated steroid hormone signaling pathway / positive regulation of phosphorylation / HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand / steroid binding / insulin-like growth factor receptor signaling pathway / molecular condensate scaffold activity / epithelial cell proliferation / G protein-coupled receptor activity / negative regulation of extrinsic apoptotic signaling pathway / positive regulation of cell differentiation / SUMOylation of intracellular receptors / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / multicellular organism growth / beta-catenin binding / transcription coactivator binding / positive regulation of miRNA transcription / Nuclear Receptor transcription pathway / nuclear receptor activity / negative regulation of epithelial cell proliferation / male gonad development / MAPK cascade / cell-cell signaling / positive regulation of NF-kappaB transcription factor activity / ATPase binding / spermatogenesis / DNA-binding transcription activator activity, RNA polymerase II-specific / in utero embryonic development / RNA polymerase II-specific DNA-binding transcription factor binding / transcription by RNA polymerase II / positive regulation of MAPK cascade / molecular adaptor activity / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / Ub-specific processing proteases / nuclear speck / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of cell population proliferation / signaling receptor binding / chromatin binding / positive regulation of cell population proliferation / positive regulation of gene expression / chromatin / positive regulation of DNA-templated transcription / enzyme binding / negative regulation of transcription by RNA polymerase II / signal transduction / positive regulation of transcription by RNA polymerase II / protein-containing complex / zinc ion binding / nucleoplasm / nucleus / plasma membrane / cytoplasm / cytosol 類似検索 - 分子機能 Androgen receptor / Androgen receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor ... Androgen receptor / Androgen receptor / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.2 Å 詳細データ登録者 Lallous, N. / Li, H. / Radaeva, M. / Dalal, K. / Leblanc, E. / Ban, F. / Ciesielski, F. / Chow, B. / Morin, M. / Singh, K. ...Lallous, N. / Li, H. / Radaeva, M. / Dalal, K. / Leblanc, E. / Ban, F. / Ciesielski, F. / Chow, B. / Morin, M. / Singh, K. / Rennie, P.S. / Cherkasov, A. 資金援助 カナダ, 1件 詳細 詳細を隠す組織 認可番号 国 Other private 272111 カナダ
引用ジャーナル : Cells / 年 : 2022タイトル : Structure-Based Study to Overcome Cross-Reactivity of Novel Androgen Receptor Inhibitors.著者 : Radaeva, M. / Li, H. / LeBlanc, E. / Dalal, K. / Ban, F. / Ciesielski, F. / Chow, B. / Morin, H. / Awrey, S. / Singh, K. / Rennie, P.S. / Lallous, N. / Cherkasov, A. 履歴 登録 2022年8月10日 登録サイト : RCSB / 処理サイト : RCSB置き換え 2022年9月14日 ID : 4U4K 改定 1.0 2022年9月14日 Provider : repository / タイプ : Initial release改定 1.1 2022年10月5日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.journal_volume / _citation.pdbx_database_id_PubMed / _citation.title改定 1.2 2022年11月16日 Group : Advisory / カテゴリ : pdbx_database_PDB_obs_spr改定 1.3 2022年11月30日 Group : Advisory / カテゴリ : pdbx_database_PDB_obs_spr改定 1.4 2024年4月3日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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