Entry | Database: PDB / ID: 8dnd |
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Title | Crystal structure of Bothrops pirajai Piratoxin-I (PrTX-I) and synthetic inhibitor Varespladib (LY315920) |
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Components | Basic phospholipase A2 homolog piratoxin-1 |
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Keywords | TOXIN/ANTITOXIN / PrTX-I / varespladib / Bothrops pirajai / PLA2-like toxin / TOXIN / TOXIN-ANTITOXIN complex |
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Function / homology | Function and homology information
calcium-dependent phospholipase A2 activity / arachidonate secretion / phospholipid metabolic process / lipid catabolic process / negative regulation of T cell proliferation / phospholipid binding / toxin activity / calcium ion binding / extracellular regionSimilarity search - Function Phospholipase A2, aspartic acid active site / Phospholipase A2 aspartic acid active site. / Phospholipase A2 / Phospholipase A2, histidine active site / Phospholipase A2 histidine active site. / Phospholipase A2 / Phospholipase A2 domain / Phospholipase A2 / Phospholipase A2 domain superfamilySimilarity search - Domain/homology |
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Biological species | Bothrops pirajai (snake) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 2.018 Å |
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Authors | Salvador, G.H.M. / Fontes, M.R.M. |
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Funding support | Brazil, 2items Organization | Grant number | Country |
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Sao Paulo Research Foundation (FAPESP) | 2020/10143-7 | Brazil | Brazilian National Council for Scientific and Technological Development (CNPq) | | Brazil |
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Citation | Journal: Biochimie / Year: 2023 Title: Structural basis of the myotoxic inhibition of the Bothrops pirajai PrTX-I by the synthetic varespladib. Authors: Salvador, G.H.M. / Pinto, E.K.R. / Ortolani, P.L. / Fortes-Dias, C.L. / Cavalcante, W.L.G. / Soares, A.M. / Lomonte, B. / Lewin, M.R. / Fontes, M.R.M. |
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History | Deposition | Jul 11, 2022 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Aug 2, 2023 | Provider: repository / Type: Initial release |
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Revision 1.1 | Aug 9, 2023 | Group: Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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