Entry | Database: PDB / ID: 8ct8 |
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Title | Crystal structure of Drosophila melanogaster PRL/CBS-pair domain complex |
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Components | - PRL-1 phosphatase
- Unextended protein
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Keywords | PROTEIN BINDING / PRL / CBS-pair / CNNM / transporter protein / complex / UEX |
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Function / homology | Function and homology information
RAB geranylgeranylation / cellular response to carbon dioxide / magnesium ion homeostasis / intracellular monoatomic ion homeostasis / protein tyrosine/serine/threonine phosphatase activity / apicolateral plasma membrane / transmembrane transporter activity / peptidyl-tyrosine dephosphorylation / monoatomic ion transport / protein-tyrosine-phosphatase ...RAB geranylgeranylation / cellular response to carbon dioxide / magnesium ion homeostasis / intracellular monoatomic ion homeostasis / protein tyrosine/serine/threonine phosphatase activity / apicolateral plasma membrane / transmembrane transporter activity / peptidyl-tyrosine dephosphorylation / monoatomic ion transport / protein-tyrosine-phosphatase / protein tyrosine phosphatase activity / axon / intracellular membrane-bounded organelle / nucleus / plasma membrane / cytoplasmSimilarity search - Function Ancient conserved domain protein family / Ion transporter-like, CBS domain / Cyclin M transmembrane N-terminal domain / CNNM, transmembrane domain / CNNM transmembrane domain profile. / Dual specificity protein phosphatase domain / CBS domain superfamily / CBS domain / CBS domain profile. / cAMP/cGMP binding motif profile. ...Ancient conserved domain protein family / Ion transporter-like, CBS domain / Cyclin M transmembrane N-terminal domain / CNNM, transmembrane domain / CNNM transmembrane domain profile. / Dual specificity protein phosphatase domain / CBS domain superfamily / CBS domain / CBS domain profile. / cAMP/cGMP binding motif profile. / Cyclic nucleotide-binding domain / Cyclic nucleotide-binding domain superfamily / Protein-tyrosine phosphatase / Tyrosine-specific protein phosphatase, PTPase domain / Tyrosine-specific protein phosphatases domain / Tyrosine specific protein phosphatases domain profile. / Protein-tyrosine phosphatase-like / RmlC-like jelly roll foldSimilarity search - Domain/homology |
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Biological species | ![](img/tx_arthropod.gif) Drosophila melanogaster (fruit fly) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.5 Å |
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Authors | Fakih, R. / Goldstein, R.H. / Kozlov, G. / Gehring, K. |
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Funding support | Canada, 1items Organization | Grant number | Country |
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Natural Sciences and Engineering Research Council (NSERC, Canada) | RGPIN-2020-07195 | Canada |
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Citation | Journal: J.Biol.Chem. / Year: 2023 Title: Burst kinetics and CNNM binding are evolutionarily conserved properties of phosphatases of regenerating liver. Authors: Fakih, R. / Goldstein, R.H. / Kozlov, G. / Gehring, K. |
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History | Deposition | May 13, 2022 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Mar 1, 2023 | Provider: repository / Type: Initial release |
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Revision 1.1 | Mar 8, 2023 | Group: Database references / Category: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.name |
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Revision 1.2 | Apr 5, 2023 | Group: Database references / Category: citation / citation_author Item: _citation.journal_volume / _citation.title / _citation_author.name |
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Revision 1.3 | May 22, 2024 | Group: Data collection / Category: chem_comp_atom / chem_comp_bond |
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