Entry Database : PDB / ID : 8cn1 Structure visualization Downloads & linksTitle hDLG1-PDZ1 in complex with a TAX1 peptide from HTLV-1 ComponentsDisks large homolog 1 GLU-THR-GLU-VAL DetailsKeywords PROTEIN BINDING / HTLV-1 / Tax-1 / hDLG1 / PBM / protein protein interactionFunction / homology Function and homology informationFunction Domain/homology Component
regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization / regulation of protein localization to synapse / regulation of potassium ion import / L27 domain binding / regulation of potassium ion export across plasma membrane / MPP7-DLG1-LIN7 complex / membrane raft organization / hard palate development / establishment of centrosome localization / negative regulation of p38MAPK cascade ... regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization / regulation of protein localization to synapse / regulation of potassium ion import / L27 domain binding / regulation of potassium ion export across plasma membrane / MPP7-DLG1-LIN7 complex / membrane raft organization / hard palate development / establishment of centrosome localization / negative regulation of p38MAPK cascade / guanylate kinase activity / cortical microtubule organization / regulation of sodium ion transmembrane transport / embryonic skeletal system morphogenesis / astral microtubule organization / structural constituent of postsynaptic density / NrCAM interactions / lateral loop / reproductive structure development / immunological synapse formation / myelin sheath abaxonal region / peristalsis / cell projection membrane / Synaptic adhesion-like molecules / smooth muscle tissue development / bicellular tight junction assembly / positive regulation of potassium ion transport / node of Ranvier / regulation of ventricular cardiac muscle cell action potential / protein-containing complex localization / Trafficking of AMPA receptors / Assembly and cell surface presentation of NMDA receptors / establishment or maintenance of epithelial cell apical/basal polarity / amyloid precursor protein metabolic process / neurotransmitter receptor localization to postsynaptic specialization membrane / endothelial cell proliferation / lens development in camera-type eye / Activation of Ca-permeable Kainate Receptor / regulation of myelination / cortical actin cytoskeleton organization / branching involved in ureteric bud morphogenesis / establishment or maintenance of cell polarity / negative regulation of G1/S transition of mitotic cell cycle / positive regulation of actin filament polymerization / Negative regulation of NMDA receptor-mediated neuronal transmission / Unblocking of NMDA receptors, glutamate binding and activation / receptor clustering / phosphoprotein phosphatase activity / Long-term potentiation / immunological synapse / intercalated disc / basement membrane / lateral plasma membrane / potassium channel regulator activity / bicellular tight junction / phosphatase binding / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / T cell proliferation / negative regulation of T cell proliferation / cytoskeletal protein binding / Ras activation upon Ca2+ influx through NMDA receptor / actin filament polymerization / phosphatidylinositol 3-kinase/protein kinase B signal transduction / synaptic membrane / protein localization to plasma membrane / regulation of membrane potential / positive regulation of protein localization to plasma membrane / actin filament organization / adherens junction / postsynaptic density membrane / neuromuscular junction / cytoplasmic side of plasma membrane / negative regulation of ERK1 and ERK2 cascade / sarcolemma / kinase binding / cell-cell adhesion / negative regulation of epithelial cell proliferation / cell-cell junction / cell junction / regulation of cell shape / RAF/MAP kinase cascade / chemical synaptic transmission / basolateral plasma membrane / microtubule / transmembrane transporter binding / molecular adaptor activity / cadherin binding / neuron projection / membrane raft / apical plasma membrane / glutamatergic synapse / positive regulation of cell population proliferation / endoplasmic reticulum membrane / perinuclear region of cytoplasm / Golgi apparatus / negative regulation of transcription by RNA polymerase II / endoplasmic reticulum / extracellular exosome / nucleus / plasma membrane Similarity search - Function L27-1 / L27_1 / domain in receptor targeting proteins Lin-2 and Lin-7 / L27 domain / L27 domain profile. / L27 domain superfamily / Polyubiquitination (PEST) N-terminal domain of MAGUK / Disks large homologue 1, N-terminal PEST domain / Polyubiquitination (PEST) N-terminal domain of MAGUK / PDZ-associated domain of NMDA receptors ... L27-1 / L27_1 / domain in receptor targeting proteins Lin-2 and Lin-7 / L27 domain / L27 domain profile. / L27 domain superfamily / Polyubiquitination (PEST) N-terminal domain of MAGUK / Disks large homologue 1, N-terminal PEST domain / Polyubiquitination (PEST) N-terminal domain of MAGUK / PDZ-associated domain of NMDA receptors / PDZ-associated domain of NMDA receptors / Disks large 1-like / Guanylate kinase, conserved site / Guanylate kinase-like signature. / Guanylate kinase-like domain profile. / Guanylate kinase-like domain / Guanylate kinase/L-type calcium channel beta subunit / Guanylate kinase / Guanylate kinase homologues. / PDZ domain / SH3 domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Src homology 3 domains / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3 domain / P-loop containing nucleoside triphosphate hydrolase Similarity search - Domain/homologyBiological species Homo sapiens (human) Human T-cell leukemia virus type IMethod X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.09 Å DetailsAuthors Maseko, S. / Sogues, A. / Volkov, A. / Remaut, H. / Twizere, J.C. Funding support Belgium, 1items Details Hide detailsOrganization Grant number Country Fonds National de la Recherche Scientifique (FNRS) 40011260 Belgium
CitationJournal : Antiviral Res. / Year : 2023Title : Identification of small molecule antivirals against HTLV-1 by targeting the hDLG1-Tax-1 protein-protein interaction.Authors: Maseko, S.B. / Brammerloo, Y. / Van Molle, I. / Sogues, A. / Martin, C. / Gorgulla, C. / Plant, E. / Olivet, J. / Blavier, J. / Ntombela, T. / Delvigne, F. / Arthanari, H. / El Hajj, H. / ... Authors : Maseko, S.B. / Brammerloo, Y. / Van Molle, I. / Sogues, A. / Martin, C. / Gorgulla, C. / Plant, E. / Olivet, J. / Blavier, J. / Ntombela, T. / Delvigne, F. / Arthanari, H. / El Hajj, H. / Bazarbachi, A. / Van Lint, C. / Salehi-Ashtiani, K. / Remaut, H. / Ballet, S. / Volkov, A.N. / Twizere, J.C. History Deposition Feb 21, 2023 Deposition site : PDBE / Processing site : PDBERevision 1.0 Aug 2, 2023 Provider : repository / Type : Initial releaseRevision 1.1 Aug 9, 2023 Group : Database references / Category : citation / Item : _citation.journal_volumeRevision 1.2 Jun 19, 2024 Group : Data collection / Category : chem_comp_atom / chem_comp_bond
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