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- PDB-8cme: Human Leukocyte Antigen class II allotype DR1 presenting SARS-CoV... -
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Basic information
Entry | Database: PDB / ID: 8cme | ||||||
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Title | Human Leukocyte Antigen class II allotype DR1 presenting SARS-CoV-2 Membrane peptide M176-190 | ||||||
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![]() | IMMUNE SYSTEM / HLA-II / HLA-DR / HLA-DR1 / human leukocyte antigen / major histocompatibility complex / major histocompatibility complex class 2 / SARS-CoV-2 / coronavirus / COVID-19 / Membrane | ||||||
Function / homology | ![]() Maturation of protein M / SARS-CoV-2 modulates autophagy / cytoplasmic capsid assembly / myeloid dendritic cell antigen processing and presentation / antigen processing and presentation of endogenous peptide antigen via MHC class II / autolysosome membrane / regulation of T-helper cell differentiation / positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / MHC class II receptor activity / positive regulation of CD4-positive, alpha-beta T cell activation ...Maturation of protein M / SARS-CoV-2 modulates autophagy / cytoplasmic capsid assembly / myeloid dendritic cell antigen processing and presentation / antigen processing and presentation of endogenous peptide antigen via MHC class II / autolysosome membrane / regulation of T-helper cell differentiation / positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation / MHC class II receptor activity / positive regulation of CD4-positive, alpha-beta T cell activation / antigen processing and presentation of peptide or polysaccharide antigen via MHC class II / positive regulation of memory T cell differentiation / transport vesicle membrane / polysaccharide binding / Translocation of ZAP-70 to Immunological synapse / Phosphorylation of CD3 and TCR zeta chains / host cell Golgi membrane / CD28 dependent PI3K/Akt signaling / Generation of second messenger molecules / immunological synapse / endoplasmic reticulum-Golgi intermediate compartment / PD-1 signaling / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / T cell receptor binding / protein sequestering activity / MHC class II antigen presentation / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity / VEGFR2 mediated vascular permeability / trans-Golgi network membrane / lumenal side of endoplasmic reticulum membrane / clathrin-coated endocytic vesicle membrane / ER to Golgi transport vesicle membrane / cognition / peptide antigen assembly with MHC class II protein complex / MHC class II protein complex / positive regulation of T cell mediated cytotoxicity / peptide antigen binding / antigen processing and presentation of exogenous peptide antigen via MHC class II / endocytic vesicle membrane / Interferon gamma signaling / positive regulation of immune response / Downstream TCR signaling / positive regulation of T cell activation / PIP3 activates AKT signaling / MHC class II protein complex binding / late endosome membrane / TRAF3-dependent IRF activation pathway / early endosome membrane / adaptive immune response / Translation of Structural Proteins / Virion Assembly and Release / Induction of Cell-Cell Fusion / structural constituent of virion / Attachment and Entry / lysosome / immune response / Golgi membrane / lysosomal membrane / virus-mediated perturbation of host defense response / viral envelope / SARS-CoV-2 activates/modulates innate and adaptive immune responses / virion membrane / cell surface / extracellular exosome / identical protein binding / plasma membrane Similarity search - Function | ||||||
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Method | ![]() ![]() ![]() | ||||||
![]() | MacLachlan, B.J. / Mason, G.H. / Sourfield, D.O. / Godkin, A.J. / Rizkallah, P.J. | ||||||
Funding support | ![]()
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![]() | ![]() Title: Structural definition of HLA class II-presented SARS-CoV-2 epitopes reveals a mechanism to escape pre-existing CD4 + T cell immunity. Authors: Chen, Y. / Mason, G.H. / Scourfield, D.O. / Greenshields-Watson, A. / Haigh, T.A. / Sewell, A.K. / Long, H.M. / Gallimore, A.M. / Rizkallah, P. / MacLachlan, B.J. / Godkin, A. | ||||||
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 586 KB | Display | ![]() |
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PDB format | ![]() | 410.8 KB | Display | ![]() |
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-Validation report
Summary document | ![]() | 512.7 KB | Display | ![]() |
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Full document | ![]() | 519.9 KB | Display | |
Data in XML | ![]() | 40.5 KB | Display | |
Data in CIF | ![]() | 56.3 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 8cmbC ![]() 8cmcC ![]() 8cmdC ![]() 8cmfC ![]() 8cmgC ![]() 8cmhC ![]() 8cmiC C: citing same article ( |
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Similar structure data | Similarity search - Function & homology ![]() |
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Assembly
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