Entry | Database: PDB / ID: 8cjh |
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Title | Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin |
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Components | Colibactin hybrid non-ribosomal peptide synthetase/type I polyketide synthase ClbK |
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Keywords | BIOSYNTHETIC PROTEIN / polyketide Synthase / ketosynthase domain / Acyltransferase domain / Acyl Carrier Protein domain |
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Function / homology | Function and homology information
: / small molecule metabolic process / acyltransferase activity / ligase activity / phosphopantetheine binding / oxidoreductase activity / cytoplasmSimilarity search - Function Nitroreductase / Nitroreductase family / Nitroreductase-like / Condensation domain / Condensation domain / Amino acid adenylation domain / Polyketide synthase, C-terminal extension / Ketoacyl-synthetase C-terminal extension / ANL, N-terminal domain / Chloramphenicol acetyltransferase-like domain superfamily ...Nitroreductase / Nitroreductase family / Nitroreductase-like / Condensation domain / Condensation domain / Amino acid adenylation domain / Polyketide synthase, C-terminal extension / Ketoacyl-synthetase C-terminal extension / ANL, N-terminal domain / Chloramphenicol acetyltransferase-like domain superfamily / AMP-binding, conserved site / Putative AMP-binding domain signature. / Polyketide synthase, phosphopantetheine-binding domain / Phosphopantetheine attachment site / AMP-dependent synthetase/ligase / AMP-binding enzyme, C-terminal domain superfamily / AMP-binding enzyme / Beta-ketoacyl synthase / Polyketide synthase, beta-ketoacyl synthase domain / Beta-ketoacyl synthase, N-terminal / Beta-ketoacyl synthase, C-terminal / Beta-ketoacyl synthase, N-terminal domain / Beta-ketoacyl synthase, C-terminal domain / Thiolase-like / Phosphopantetheine attachment site / ACP-like superfamily / Carrier protein (CP) domain profile. / Phosphopantetheine binding ACP domainSimilarity search - Domain/homology |
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Biological species | ![](img/tx_bacteria.gif) Escherichia coli (E. coli) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.982 Å |
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Authors | Bonhomme, S. / Dessen, A. / Macheboeuf, P. |
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Funding support | France, 2items Organization | Grant number | Country |
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Other government | M32917 | France | Other government | AO12-20 | France |
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Citation | Journal: Structure / Year: 2023 Title: Architecture of a PKS-NRPS hybrid megaenzyme involved in the biosynthesis of the genotoxin colibactin. Authors: Bonhomme, S. / Contreras-Martel, C. / Dessen, A. / Macheboeuf, P. |
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History | Deposition | Feb 13, 2023 | Deposition site: PDBE / Processing site: PDBE |
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Revision 1.0 | Apr 26, 2023 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jun 14, 2023 | Group: Database references / Refinement description / Category: citation / struct_ncs_dom / struct_ncs_dom_lim Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _struct_ncs_dom.details / _struct_ncs_dom_lim.beg_auth_asym_id / _struct_ncs_dom_lim.end_auth_asym_id |
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Revision 1.2 | Jun 19, 2024 | Group: Data collection / Refinement description Category: chem_comp_atom / chem_comp_bond / struct_ncs_dom_lim Item: _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id ..._struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id |
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