- PDB-8ce3: Crystal structure of MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta... -
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基本情報
登録情報
データベース: PDB / ID: 8ce3
タイトル
Crystal structure of MGAT5 (alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase V) luminal domain with a Lys329-Ile345 loop truncation, in complex with 3D fragment 2548
要素
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A
キーワード
CARBOHYDRATE / Glycosyltransferase / fragment
機能・相同性
機能・相同性情報
alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase / alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity / N-Glycan antennae elongation / positive regulation of receptor signaling pathway via STAT / : / protein N-linked glycosylation via asparagine / protein N-linked glycosylation / protein phosphatase inhibitor activity / manganese ion binding / Maturation of spike protein ...alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase / alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity / N-Glycan antennae elongation / positive regulation of receptor signaling pathway via STAT / : / protein N-linked glycosylation via asparagine / protein N-linked glycosylation / protein phosphatase inhibitor activity / manganese ion binding / Maturation of spike protein / viral protein processing / positive regulation of cell migration / Golgi membrane / Golgi apparatus / extracellular exosome / membrane 類似検索 - 分子機能
Glycosyltransferase family 18 / Domain of unknown function DUF4525 / : / Glycosyltransferase family 18 / Domain of unknown function (DUF4525) 類似検索 - ドメイン・相同性
: / Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A 類似検索 - 構成要素
A: Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A B: Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A ヘテロ分子
根拠: gel filtration, elutes as a single peak at expected retention time for a monomer
タイプ
名称
対称操作
数
identity operation
1_555
x,y,z
1
Buried area
5390 Å2
ΔGint
-100 kcal/mol
Surface area
41820 Å2
単位格子
Length a, b, c (Å)
46.860, 68.540, 91.310
Angle α, β, γ (deg.)
107.300, 92.160, 107.050
Int Tables number
1
Space group name H-M
P1
非結晶学的対称性 (NCS)
NCSドメイン:
ID
Ens-ID
詳細
1
1
A
2
1
A
NCSドメイン領域:
Component-ID: 1 / Ens-ID: 1 / Beg auth comp-ID: SER / Beg label comp-ID: SER / End auth comp-ID: LEU / End label comp-ID: LEU / Refine code: 1 / Auth asym-ID: A / Label asym-ID: A / Auth seq-ID: 214 - 728 / Label seq-ID: 1 - 515
Dom-ID
1
2
NCSアンサンブル: (詳細: Local NCS retraints between domains: 1 2)
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要素
#1: タンパク質
Alpha-1,6-mannosylglycoprotein6-beta-N-acetylglucosaminyltransferaseA / Alpha-mannoside beta-1 / 6-N-acetylglucosaminyltransferase V / GlcNAc-T V / GNT-V / Mannoside ...Alpha-mannoside beta-1 / 6-N-acetylglucosaminyltransferase V / GlcNAc-T V / GNT-V / Mannoside acetylglucosaminyltransferase 5 / N-acetylglucosaminyl-transferase V
分子量: 58996.906 Da / 分子数: 2 / 由来タイプ: 組換発現 / 由来: (組換発現) Homo sapiens (ヒト) / 遺伝子: MGAT5, GGNT5 / 発現宿主: Trichoplusia ni (イラクサキンウワバ) 参照: UniProt: Q09328, alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase