登録情報 | データベース: PDB / ID: 8ccx |
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タイトル | Human SOD1 in complex with S-XL6 cross-linker |
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要素 | Superoxide dismutase [Cu-Zn] |
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キーワード | OXIDOREDUCTASE / SOD1 / Amyotrophic Lateral Sclerosis / ALS / pharmacological chaperone / cross-linking / stabilization |
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機能・相同性 | 機能・相同性情報
action potential initiation / neurofilament cytoskeleton organization / positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / protein phosphatase 2B binding / regulation of organ growth / relaxation of vascular associated smooth muscle / response to superoxide / retrograde axonal transport / anterograde axonal transport / peripheral nervous system myelin maintenance ...action potential initiation / neurofilament cytoskeleton organization / positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / protein phosphatase 2B binding / regulation of organ growth / relaxation of vascular associated smooth muscle / response to superoxide / retrograde axonal transport / anterograde axonal transport / peripheral nervous system myelin maintenance / regulation of protein kinase activity / regulation of T cell differentiation in thymus / retina homeostasis / superoxide anion generation / negative regulation of cholesterol biosynthetic process / auditory receptor cell stereocilium organization / hydrogen peroxide biosynthetic process / myeloid cell homeostasis / positive regulation of catalytic activity / muscle cell cellular homeostasis / regulation of GTPase activity / heart contraction / superoxide metabolic process / superoxide dismutase / negative regulation of reproductive process / Detoxification of Reactive Oxygen Species / negative regulation of developmental process / transmission of nerve impulse / superoxide dismutase activity / : / neuronal action potential / regulation of multicellular organism growth / response to axon injury / ectopic germ cell programmed cell death / positive regulation of superoxide anion generation / ovarian follicle development / positive regulation of phagocytosis / axon cytoplasm / glutathione metabolic process / embryo implantation / dendrite cytoplasm / Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation / removal of superoxide radicals / reactive oxygen species metabolic process / thymus development / regulation of mitochondrial membrane potential / positive regulation of cytokine production / placenta development / locomotory behavior / determination of adult lifespan / sensory perception of sound / regulation of blood pressure / negative regulation of inflammatory response / response to hydrogen peroxide / mitochondrial intermembrane space / small GTPase binding / Platelet degranulation / peroxisome / protein-folding chaperone binding / gene expression / response to heat / cytoplasmic vesicle / spermatogenesis / response to ethanol / intracellular iron ion homeostasis / negative regulation of neuron apoptotic process / positive regulation of MAPK cascade / mitochondrial matrix / response to xenobiotic stimulus / positive regulation of apoptotic process / copper ion binding / neuronal cell body / apoptotic process / protein-containing complex / mitochondrion / extracellular space / zinc ion binding / extracellular exosome / extracellular region / nucleoplasm / identical protein binding / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Copper/Zinc superoxide dismutase signature 1. / Superoxide dismutase, copper/zinc, binding site / Copper/Zinc superoxide dismutase signature 2. / Superoxide dismutase, copper/zinc binding domain / Copper/zinc superoxide dismutase (SODC) / Superoxide dismutase (Cu/Zn) / superoxide dismutase copper chaperone / Superoxide dismutase-like, copper/zinc binding domain superfamily類似検索 - ドメイン・相同性 COPPER (II) ION / butane-1,4-dithiol / Superoxide dismutase [Cu-Zn]類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / 分子置換 / 解像度: 1.665 Å |
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データ登録者 | Antonyuk, S.V. / Hossain, A. / Agar, J.N. / Hasnain, S.S. |
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資金援助 | 米国, 3件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Institute of Neurological Disorders and Stroke (NIH/NINDS) | R01NS065263 | 米国 | National Science Foundation (NSF, United States) | MCB-1517290 | 米国 | National Science Foundation (NSF, United States) | CHE-1905214 | 米国 |
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引用 | ジャーナル: Plos Biol. / 年: 2024 タイトル: Evaluating protein cross-linking as a therapeutic strategy to stabilize SOD1 variants in a mouse model of familial ALS. 著者: Hossain, M.A. / Sarin, R. / Donnelly, D.P. / Miller, B.C. / Weiss, A. / McAlary, L. / Antonyuk, S.V. / Salisbury, J.P. / Amin, J. / Conway, J.B. / Watson, S.S. / Winters, J.N. / Xu, Y. / ...著者: Hossain, M.A. / Sarin, R. / Donnelly, D.P. / Miller, B.C. / Weiss, A. / McAlary, L. / Antonyuk, S.V. / Salisbury, J.P. / Amin, J. / Conway, J.B. / Watson, S.S. / Winters, J.N. / Xu, Y. / Alam, N. / Brahme, R.R. / Shahbazian, H. / Sivasankar, D. / Padmakumar, S. / Sattarova, A. / Ponmudiyan, A.C. / Gawde, T. / Verrill, D.E. / Yang, W. / Kannapadi, S. / Plant, L.D. / Auclair, J.R. / Makowski, L. / Petsko, G.A. / Ringe, D. / Agar, N.Y.R. / Greenblatt, D.J. / Ondrechen, M.J. / Chen, Y. / Yerbury, J.J. / Manetsch, R. / Hasnain, S.S. / Brown Jr., R.H. / Agar, J.N. |
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履歴 | 登録 | 2023年1月27日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2023年12月13日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年2月7日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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