- PDB-8c2f: Structure of 14-3-3 sigma delta C with electrophilic peptide 3MHR-5 -
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Basic information
Entry
Database: PDB / ID: 8c2f
Title
Structure of 14-3-3 sigma delta C with electrophilic peptide 3MHR-5
Components
14-3-3 protein sigma
ARG-ALA-HIS-SEP-CYS-PRO-ALA-SER-LEU-GLN
Keywords
PROTEIN BINDING / 14-3-3 sigma / 3MHR-5 / covalent
Function / homology
Function and homology information
regulation of epidermal cell division / protein kinase C inhibitor activity / positive regulation of epidermal cell differentiation / keratinocyte development / keratinization / Regulation of localization of FOXO transcription factors / keratinocyte proliferation / phosphoserine residue binding / Activation of BAD and translocation to mitochondria / negative regulation of keratinocyte proliferation ...regulation of epidermal cell division / protein kinase C inhibitor activity / positive regulation of epidermal cell differentiation / keratinocyte development / keratinization / Regulation of localization of FOXO transcription factors / keratinocyte proliferation / phosphoserine residue binding / Activation of BAD and translocation to mitochondria / negative regulation of keratinocyte proliferation / establishment of skin barrier / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / negative regulation of stem cell proliferation / RHO GTPases activate PKNs / protein kinase A signaling / protein sequestering activity / negative regulation of innate immune response / protein export from nucleus / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / positive regulation of protein export from nucleus / release of cytochrome c from mitochondria / stem cell proliferation / Translocation of SLC2A4 (GLUT4) to the plasma membrane / TP53 Regulates Metabolic Genes / negative regulation of protein kinase activity / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / intrinsic apoptotic signaling pathway in response to DNA damage / positive regulation of cell growth / regulation of cell cycle / cadherin binding / protein kinase binding / negative regulation of transcription by RNA polymerase II / signal transduction / extracellular space / extracellular exosome / identical protein binding / nucleus / cytoplasm / cytosol Similarity search - Function
14-3-3 protein sigma / 14-3-3 proteins signature 2. / 14-3-3 protein, conserved site / 14-3-3 proteins signature 1. / 14-3-3 protein / 14-3-3 homologues / 14-3-3 domain / 14-3-3 domain superfamily / 14-3-3 protein Similarity search - Domain/homology
Protein / Protein/peptide , 2 types, 2 molecules AP
#1: Protein
14-3-3proteinsigma / Epithelial cell marker protein 1 / Stratifin
Mass: 26542.914 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: SFN, HME1 / Production host: Escherichia coli (E. coli) / References: UniProt: P31947
#2: Protein/peptide
ARG-ALA-HIS-SEP-CYS-PRO-ALA-SER-LEU-GLN
Mass: 1151.190 Da / Num. of mol.: 1 / Source method: obtained synthetically Details: Cme = covalent crosslinker bound to the cysteine, which reacts with Lys122 of 14-3-3 sigma delta C Source: (synth.) Homo sapiens (human)